Template:Adult NAC dosing - Revision history

Ostermayer: Marked this version for translation

2026-01-20T07:35:40Z

Marked this version for translation

← Revisión anterior		Revisión del 07:35 20 ene 2026
Línea 2:		Línea 2:
	<translate>		<translate>

	====PO====		====PO==== <!--T:1-->

			<!--T:2-->
	*Less preferred than IV route due to unpleasant taste and smell		*Less preferred than IV route due to unpleasant taste and smell
	*140 mg/kg PO load		*140 mg/kg PO load
Línea 9:		Línea 10:


	====IV====		====IV==== <!--T:3-->

			<!--T:4-->
	*Loading dose: 150mg/kg in 100 mL D5W over 60min		*Loading dose: 150mg/kg in 100 mL D5W over 60min
	*Second (maintenance) dose: 50mg/kg in 250 mL D5W over 4hr		*Second (maintenance) dose: 50mg/kg in 250 mL D5W over 4hr
Línea 16:		Línea 18:


	====Comments====		====Comments==== <!--T:5-->

			<!--T:6-->
	*Almost 100% effective if given <8 hr post-ingestion; less effective if 16-24 hr post-ingestion		*Almost 100% effective if given <8 hr post-ingestion; less effective if 16-24 hr post-ingestion
	*May still be useful >24 hr post-ingestion, even with fulminant hepatic failure. Give NAC until LFTs improve (not until APAP level is 0) <ref>Keays R, Harrison PM, Wendon JA, et al. Intravenous acetylcysteine in paracetamol-induced fulminant hepatic failure: a prospective controlled trial. BMJ. 1991;303(6809):1026-1029. (Prospective randomized controlled trial; 50 patients)</ref> <ref>Harrison PM, Keays R, Bray GP, et al. Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of N-acetylcysteine. Lancet. 1990;335(8705):1572- 1573. (Retrospective analysis; 100 patients)</ref>		*May still be useful >24 hr post-ingestion, even with fulminant hepatic failure. Give NAC until LFTs improve (not until APAP level is 0) <ref>Keays R, Harrison PM, Wendon JA, et al. Intravenous acetylcysteine in paracetamol-induced fulminant hepatic failure: a prospective controlled trial. BMJ. 1991;303(6809):1026-1029. (Prospective randomized controlled trial; 50 patients)</ref> <ref>Harrison PM, Keays R, Bray GP, et al. Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of N-acetylcysteine. Lancet. 1990;335(8705):1572- 1573. (Retrospective analysis; 100 patients)</ref>
	*Be aware NAC treatment may affect PT. May see a dose-dependent increase in PT following NAC in patients without hepatotoxicity. <ref>Wasserman GS, Garg U. Intravenous administration of Nacetylcysteine: interference with coagulopathy testing. Ann Emerg Med. 2004;44(5):546-547. (Letter)</ref>		*Be aware NAC treatment may affect PT. May see a dose-dependent increase in PT following NAC in patients without hepatotoxicity. <ref>Wasserman GS, Garg U. Intravenous administration of Nacetylcysteine: interference with coagulopathy testing. Ann Emerg Med. 2004;44(5):546-547. (Letter)</ref>
	</translate>		</translate>

Ostermayer at 07:35, 20 January 2026

2026-01-20T07:35:25Z

← Revisión anterior		Revisión del 07:35 20 ene 2026
Línea 1:		Línea 1:
	<languages/>		<noinclude><languages/></noinclude>
	<translate>		<translate>

Ostermayer: Prepared the page for translation

2026-01-20T07:35:06Z

Prepared the page for translation

← Revisión anterior		Revisión del 07:35 20 ene 2026
Línea 1:		Línea 1:
			<languages/>
			<translate>

	====PO====		====PO====

	*Less preferred than IV route due to unpleasant taste and smell		*Less preferred than IV route due to unpleasant taste and smell
	*140 mg/kg PO load		*140 mg/kg PO load
	*70 mg/kg PO q4hr x17 doses additional; dilute to 5% soln		*70 mg/kg PO q4hr x17 doses additional; dilute to 5% soln


	====IV====		====IV====

	*Loading dose: 150mg/kg in 100 mL D5W over 60min		*Loading dose: 150mg/kg in 100 mL D5W over 60min
	*Second (maintenance) dose: 50mg/kg in 250 mL D5W over 4hr		*Second (maintenance) dose: 50mg/kg in 250 mL D5W over 4hr
	*Third dose: 100mg/kg in 500 mL D5W over 16hr		*Third dose: 100mg/kg in 500 mL D5W over 16hr


	====Comments====		====Comments====

	*Almost 100% effective if given <8 hr post-ingestion; less effective if 16-24 hr post-ingestion		*Almost 100% effective if given <8 hr post-ingestion; less effective if 16-24 hr post-ingestion
	*May still be useful >24 hr post-ingestion, even with fulminant hepatic failure. Give NAC until LFTs improve (not until APAP level is 0) <ref>Keays R, Harrison PM, Wendon JA, et al. Intravenous acetylcysteine in paracetamol-induced fulminant hepatic failure: a prospective controlled trial. BMJ. 1991;303(6809):1026-1029. (Prospective randomized controlled trial; 50 patients)</ref> <ref>Harrison PM, Keays R, Bray GP, et al. Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of N-acetylcysteine. Lancet. 1990;335(8705):1572- 1573. (Retrospective analysis; 100 patients)</ref>		*May still be useful >24 hr post-ingestion, even with fulminant hepatic failure. Give NAC until LFTs improve (not until APAP level is 0) <ref>Keays R, Harrison PM, Wendon JA, et al. Intravenous acetylcysteine in paracetamol-induced fulminant hepatic failure: a prospective controlled trial. BMJ. 1991;303(6809):1026-1029. (Prospective randomized controlled trial; 50 patients)</ref> <ref>Harrison PM, Keays R, Bray GP, et al. Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of N-acetylcysteine. Lancet. 1990;335(8705):1572- 1573. (Retrospective analysis; 100 patients)</ref>
	*Be aware NAC treatment may affect PT. May see a dose-dependent increase in PT following NAC in patients without hepatotoxicity. <ref>Wasserman GS, Garg U. Intravenous administration of Nacetylcysteine: interference with coagulopathy testing. Ann Emerg Med. 2004;44(5):546-547. (Letter)</ref>		*Be aware NAC treatment may affect PT. May see a dose-dependent increase in PT following NAC in patients without hepatotoxicity. <ref>Wasserman GS, Garg U. Intravenous administration of Nacetylcysteine: interference with coagulopathy testing. Ann Emerg Med. 2004;44(5):546-547. (Letter)</ref>
			</translate>

Lyssa1219: /* PO */

2020-04-20T20:02:38Z

← Revisión anterior		Revisión del 20:02 20 abr 2020
Línea 1:		Línea 1:
	====PO====		====PO====
			*Less preferred than IV route due to unpleasant taste and smell
	*140 mg/kg PO load		*140 mg/kg PO load
	*70 mg/kg PO q4hr x17 doses additional; dilute to 5% soln		*70 mg/kg PO q4hr x17 doses additional; dilute to 5% soln

Spenceemmett: /* PO */

2018-08-28T17:49:02Z

← Revisión anterior		Revisión del 17:49 28 ago 2018
Línea 1:		Línea 1:
	====PO====		====PO====
	*~~140mg~~/kg PO load		*140 mg/kg PO load
	*~~70mg~~/kg PO q4hr x17 doses additional; dilute to 5% soln		*70 mg/kg PO q4hr x17 doses additional; dilute to 5% soln

	====IV====		====IV====

Ostermayer: Created page with "====PO==== 140mg/kg PO load 70mg/kg PO q4hr x17 doses additional; dilute to 5% soln ====IV==== Loading dose: 150mg/kg in 100 mL D5W over 60min Second (maintenance) dose:..."

2015-12-20T16:05:42Z

Created page with "====PO==== *140mg/kg PO load *70mg/kg PO q4hr x17 doses additional; dilute to 5% soln ====IV==== *Loading dose: 150mg/kg in 100 mL D5W over 60min *Second (maintenance) dose:..."

Página nueva

====PO====
*140mg/kg PO load
*70mg/kg PO q4hr x17 doses additional; dilute to 5% soln

====IV====
*Loading dose: 150mg/kg in 100 mL D5W over 60min
*Second (maintenance) dose: 50mg/kg in 250 mL D5W over 4hr
*Third dose: 100mg/kg in 500 mL D5W over 16hr

====Comments====
*Almost 100% effective if given <8 hr post-ingestion; less effective if 16-24 hr post-ingestion
*May still be useful >24 hr post-ingestion, even with fulminant hepatic failure. Give NAC until LFTs improve (not until APAP level is 0) <ref>Keays R, Harrison PM, Wendon JA, et al. Intravenous acetylcysteine in paracetamol-induced fulminant hepatic failure: a prospective controlled trial. BMJ. 1991;303(6809):1026-1029. (Prospective randomized controlled trial; 50 patients)</ref> <ref>Harrison PM, Keays R, Bray GP, et al. Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of N-acetylcysteine. Lancet. 1990;335(8705):1572- 1573. (Retrospective analysis; 100 patients)</ref>
*Be aware NAC treatment may affect PT. May see a dose-dependent increase in PT following NAC in patients without hepatotoxicity. <ref>Wasserman GS, Garg U. Intravenous administration of Nacetylcysteine: interference with coagulopathy testing. Ann Emerg Med. 2004;44(5):546-547. (Letter)</ref>