Sweet's syndrome - Revision history

Rossdonaldson1: /* Background */

2024-12-11T18:15:52Z

Background

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	==Background==		==Background==
			{{Skin anatomy background images}}
	* Acute febrile neutrophilic dermatosis		* Acute febrile neutrophilic dermatosis
	* Rare skin condition		* Rare skin condition

Elcatracho: /* Differential Diagnosis */

2021-02-08T20:37:14Z

Differential Diagnosis

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	**[[Enterovirus]]		**[[Enterovirus]]
	**[[Fifths disease]]		**[[Fifths disease]]
	**[[~~HSV~~ 6]]		**[[HHV 6]]
	**[[Leptospirosis]]		**[[Leptospirosis]]
	**[[Lyme]]		**[[Lyme]]

Elcatracho: /* Differential Diagnosis */

2021-01-27T03:03:28Z

Differential Diagnosis

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 ==Differential Diagnosis==
+*Noninfectious
 ==Evaluation==

Elcatracho: /* Clinical Features */

2021-01-27T03:01:42Z

Clinical Features

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	[[File:Sweet's Syndrome.png\|400px\|thumb\|Sweet's Syndrome of index finger<ref>Cohen, P.R. Sweet's syndrome – a comprehensive review of an acute febrile neutrophilic dermatosis. Orphanet J Rare Dis 2, 34 (2007). https://doi.org/10.1186/1750-1172-2-34</ref>]]		[[File:Sweet's Syndrome.png\|400px\|thumb\|Sweet's Syndrome of index finger<ref>Cohen, P.R. Sweet's syndrome – a comprehensive review of an acute febrile neutrophilic dermatosis. Orphanet J Rare Dis 2, 34 (2007). https://doi.org/10.1186/1750-1172-2-34</ref>]]
	[[File:PMC1963326 1750-1172-2-34-10.png\|thumb\|Sweet's syndrome with lesions distributed in a sporotrichoid pattern.]]		[[File:PMC1963326 1750-1172-2-34-10.png\|thumb\|Sweet's syndrome with lesions distributed in a sporotrichoid pattern.]]
			[[File:Sweets.jpeg\|thumb\|Targetoid papules and plaques in Sweet's syndrome]]
	* Cutaneous disease		* Cutaneous disease
	** Painful, edematous, and erythematous papules, plaques, or nodules		** Painful, edematous, and erythematous papules, plaques, or nodules

ClaireLewis: /* Management */

2020-10-25T17:52:54Z

Management

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	==Management==		==Management==
	* Systemic glucocorticoids - [[prednisone]] 0.5 - 1.0 mg/kg per day with taper after symptom improvement		* Systemic glucocorticoids - [[prednisone]] 0.5 - 1.0 mg/kg per day with taper after symptom improvement
	* [[topical ~~coritcosteroids~~\|Topical and intralesional corticosteroids]] - limited data, mostly used as adjunct, for mild disease (<5% BSA), or absence of systemic symptoms		* [[topical corticosteroids\|Topical and intralesional corticosteroids]] - limited data, mostly used as adjunct, for mild disease (<5% BSA), or absence of systemic symptoms
	* Alternatives agents include colchicine, dapsone, potassium iodide if steroids contraindicated		* Alternatives agents include colchicine, dapsone, potassium iodide if steroids contraindicated
	* Referral to dermatology for biopsy		* Referral to dermatology for biopsy

ClaireLewis at 17:52, 25 October 2020

2020-10-25T17:52:33Z

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	** Usually upper extremities > lower extremities, with asymmetrical distribution		** Usually upper extremities > lower extremities, with asymmetrical distribution
	* Extracutaneous disease: neutrophilic infiltration of organ systems		* Extracutaneous disease: neutrophilic infiltration of organ systems
	** Ocular infiltration (most common): ~~conjuctivitis~~, scleritis, keratitis, iritis		** Ocular infiltration (most common): [[conjunctivitis]], [[scleritis]], keratitis, [[iritis]]
	** Muscular system: arthralgias, arthritis, myalgia		** Muscular system: [[arthralgias]], [[arthritis]], [[myalgia]]
	** Less commonly CNS, cardiovascular system, pulmonary system, liver, intestines, kidneys, bones		** Less commonly CNS, cardiovascular system, pulmonary system, liver, intestines, kidneys, bones
	* [[Fever]] and leukocytosis		* [[Fever]] and [[leukocytosis]]

	==Differential Diagnosis==		==Differential Diagnosis==
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	==Management==		==Management==
	* Systemic glucocorticoids - prednisone 0.5 - 1.0 mg/kg per day with taper after symptom improvement		* Systemic glucocorticoids - [[prednisone]] 0.5 - 1.0 mg/kg per day with taper after symptom improvement
	* Topical and intralesional corticosteroids - limited data, mostly used as adjunct, for mild disease (<5% BSA), or absence of systemic symptoms		* [[topical coritcosteroids\|Topical and intralesional corticosteroids]] - limited data, mostly used as adjunct, for mild disease (<5% BSA), or absence of systemic symptoms
	* Alternatives agents include colchicine, dapsone, potassium iodide if steroids contraindicated		* Alternatives agents include colchicine, dapsone, potassium iodide if steroids contraindicated
	* Referral to dermatology for biopsy		* Referral to dermatology for biopsy
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	==References==		==References==
	<references/>		<references/>
			[[Category:Dermatology]]

Rossdonaldson1: /* Clinical Features */

2020-09-09T18:03:29Z

Clinical Features

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	==Clinical Features==		==Clinical Features==
	[[File:Sweet's Syndrome.png\|400px\|thumb\|Sweet's Syndrome of index finger<ref>Cohen, P.R. Sweet's syndrome – a comprehensive review of an acute febrile neutrophilic dermatosis. Orphanet J Rare Dis 2, 34 (2007). https://doi.org/10.1186/1750-1172-2-34</ref>]]		[[File:Sweet's Syndrome.png\|400px\|thumb\|Sweet's Syndrome of index finger<ref>Cohen, P.R. Sweet's syndrome – a comprehensive review of an acute febrile neutrophilic dermatosis. Orphanet J Rare Dis 2, 34 (2007). https://doi.org/10.1186/1750-1172-2-34</ref>]]
			[[File:PMC1963326 1750-1172-2-34-10.png\|thumb\|Sweet's syndrome with lesions distributed in a sporotrichoid pattern.]]
	* Cutaneous disease		* Cutaneous disease
	** Painful, edematous, and erythematous papules, plaques, or nodules		** Painful, edematous, and erythematous papules, plaques, or nodules

Rossdonaldson1 at 18:01, 9 September 2020

2020-09-09T18:01:35Z

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	==External Links==		==External Links==
			*https://dermnetnz.org/topics/acute-febrile-neutrophilic-dermatosis/

	==References==		==References==
	<references/>		<references/>
	~~https://dermnetnz.org/topics/acute-febrile-neutrophilic-dermatosis/~~

Rossdonaldson1 at 18:01, 9 September 2020

2020-09-09T18:01:05Z

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	* Classic Sweet syndrome affects women > men		* Classic Sweet syndrome affects women > men
	* Unclear pathologenesis, but possibly factors include hypersensitivity reaction, cytokine dysregulation, or genetic susceptibility		* Unclear pathologenesis, but possibly factors include hypersensitivity reaction, cytokine dysregulation, or genetic susceptibility

			===Etiologies===
			* Classical Sweet syndrome, usually secondary to:
			** Infection: Typically 1 to 3 weeks following [[upper respiratory infection]] or gastrointestinal infection
			** Inflammatory bowel disease: [[Crohn's disease]] or [[ulcerative colitis]]
			** [[Pregnancy]]
			* Malignancy-associated Sweet syndrome
			** Hematologic (~85%), most commonly [[acute myeloid leukemia]]
			** Solid tumor (~15%), most commonly carcinoma of GU organs, breasts, GI tract
			* Drug-induced Sweet syndrome, most commonly granulocyte-colony stimulating factor (G-CSF)
			** Typically 2 weeks after drug exposure in patient without prior exposure
			* [[Fever and rash]]

	==Clinical Features==		==Clinical Features==
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	==Differential Diagnosis==		==Differential Diagnosis==
	* Classical Sweet syndrome, usually secondary to:
	** Infection: Typically 1 to 3 weeks following [[upper respiratory infection]] or gastrointestinal infection
	** Inflammatory bowel disease: [[Crohn's disease]] or [[ulcerative colitis]]
	** [[Pregnancy]]
	* Malignancy-associated Sweet syndrome
	** Hematologic (~85%), most commonly [[acute myeloid leukemia]]
	** Solid tumor (~15%), most commonly carcinoma of GU organs, breasts, GI tract
	* Drug-induced Sweet syndrome, most commonly granulocyte-colony stimulating factor (G-CSF)
	** Typically 2 weeks after drug exposure in patient without prior exposure
	* [[Fever and rash]]


	==Evaluation==		==Evaluation==
			===Workup===
	* CBC		* CBC
	** leukocytosis with neutrophilia		** leukocytosis with neutrophilia
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	* CRP		* CRP

	Major criteria		===Diagnosis===
			====Major criteria====
	* Abrupt onset painful erythematous plaques or nodules		* Abrupt onset painful erythematous plaques or nodules
	* Histopathological evidence of neutrophilic infiltrate without evidence of leukocyoclastic vasculitis		* Histopathological evidence of neutrophilic infiltrate without evidence of leukocyoclastic vasculitis

	Minor criteria		====Minor criteria====
	* Fever		* [[Fever]]
	* Associated malignancy, IBD, pregnancy, preceding URI, preceding GI infection		* Associated malignancy, [[IBD]], [[pregnancy]], preceding [[URI]], preceding GI infection
	* Improvement with treatment with systemic steroids		* Improvement with treatment with systemic steroids
	* Abnormal labs (3+ of following): ESR > 20, elevated CRP, leukocytosis, neutrophilic predominance		* Abnormal labs (3+ of following): ESR > 20, elevated CRP, leukocytosis, neutrophilic predominance

NadavNahumi: /* Clinical Features */

2020-03-28T21:47:46Z

Clinical Features

← Revisión anterior		Revisión del 21:47 28 mar 2020
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	==Clinical Features==		==Clinical Features==
			[[File:Sweet's Syndrome.png\|400px\|thumb\|Sweet's Syndrome of index finger<ref>Cohen, P.R. Sweet's syndrome – a comprehensive review of an acute febrile neutrophilic dermatosis. Orphanet J Rare Dis 2, 34 (2007). https://doi.org/10.1186/1750-1172-2-34</ref>]]
	* Cutaneous disease		* Cutaneous disease
	** Painful, edematous, and erythematous papules, plaques, or nodules		** Painful, edematous, and erythematous papules, plaques, or nodules