Spironolactone - Revision history

Danbot: Add peer-reviewed reference

2026-03-22T10:16:46Z

Add peer-reviewed reference

← Revisión anterior		Revisión del 10:16 22 mar 2026
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	==Administration==		==Administration==
	*Type: [[Antihypertensive]]; [[potassium sparing diuretic]]; aldosterone receptor antagonist		*Type: [[Antihypertensive]]; [[potassium sparing diuretic]]; aldosterone receptor antagonist<ref>Pitt B, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med. 1999;341(10):709-717. PMID 10471456</ref>
	*Dosage Forms: 25,50,100		*Dosage Forms: 25,50,100
	*Routes of Administration: Oral		*Routes of Administration: Oral

Mholtz: Text replacement - "qid" to "QID"

2017-07-07T12:41:13Z

Text replacement - "qid" to "QID"

← Revisión anterior		Revisión del 12:41 7 jul 2017
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	===[[Hypokalemia]], diuretic-induced===		===[[Hypokalemia]], diuretic-induced===
	*25-100mg/day PO divided QD-~~qid~~		*25-100mg/day PO divided QD-QID

	===[[CHF]], NYHA Class III/IV===		===[[CHF]], NYHA Class III/IV===
Línea 36:		Línea 36:
	==Pediatric Dosing==		==Pediatric Dosing==
	===Edema===		===Edema===
	*1-3.3mg/kg/day PO divided QD-~~qid~~		*1-3.3mg/kg/day PO divided QD-QID
	**Max: 3.3mg/kg/day up to 200mg/day		**Max: 3.3mg/kg/day up to 200mg/day
	**Off label use		**Off label use

	===Hyperaldosteronism test===		===Hyperaldosteronism test===
	*125-375mg/m^2/day PO divided bid-~~qid~~		*125-375mg/m^2/day PO divided bid-QID
	**Max: 375mg/m^2/day		**Max: 375mg/m^2/day
	**Off label use		**Off label use

Mholtz: Text replacement - "qd" to "QD"

2017-07-07T07:36:23Z

Text replacement - "qd" to "QD"

← Revisión anterior		Revisión del 07:36 7 jul 2017
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	==Adult Dosing==		==Adult Dosing==
	===Edema===		===Edema===
	*25-200mg/day PO divided qd-bid		*25-200mg/day PO divided QD-bid
	**For edema associated with [[CHF]], [[cirrhosis]], or [[nephrotic syndrome]]		**For edema associated with [[CHF]], [[cirrhosis]], or [[nephrotic syndrome]]

	===[[Hypertension]]===		===[[Hypertension]]===
	*25-50mg/day PO divided qd-bid		*25-50mg/day PO divided QD-bid
	**Start: 12.5mg PO qd		**Start: 12.5mg PO QD

	===Hyperaldosteronism, primary===		===Hyperaldosteronism, primary===
	*100-400mg PO qd		*100-400mg PO QD

	===[[Hypokalemia]], diuretic-induced===		===[[Hypokalemia]], diuretic-induced===
	*25-100mg/day PO divided qd-qid		*25-100mg/day PO divided QD-qid

	===[[CHF]], NYHA Class III/IV===		===[[CHF]], NYHA Class III/IV===
	*25mg PO qd		*25mg PO QD
	**Use with standard treatment; may increase to 50mg/day after 8wk for worsening CHF if K stable		**Use with standard treatment; may increase to 50mg/day after 8wk for worsening CHF if K stable
	**May decrease to 25mg qod if hyperkalemia; hold if K >5 mEq/L or creatinine >4mg/dL		**May decrease to 25mg qod if hyperkalemia; hold if K >5 mEq/L or creatinine >4mg/dL

	===Hirsutism, idiopathic===		===Hirsutism, idiopathic===
	*50-200mg PO qd		*50-200mg PO QD
	**Off label use		**Off label use

	===Acne vulgaris===		===Acne vulgaris===
	*50-200mg PO qd		*50-200mg PO QD
	**Start: 25mg PO qd		**Start: 25mg PO QD
	**Off label use		**Off label use

	==Pediatric Dosing==		==Pediatric Dosing==
	===Edema===		===Edema===
	*1-3.3mg/kg/day PO divided qd-qid		*1-3.3mg/kg/day PO divided QD-qid
	**Max: 3.3mg/kg/day up to 200mg/day		**Max: 3.3mg/kg/day up to 200mg/day
	**Off label use		**Off label use

Rossdonaldson1: /* Contraindications */

2016-09-29T20:24:44Z

Contraindications

← Revisión anterior		Revisión del 20:24 29 sep 2016
Línea 59:		Línea 59:
	*anuria		*anuria
	*renal impairment, acute		*renal impairment, acute
	*hyperkalemia		*[[hyperkalemia]]
	*Addison disease		*Addison disease

Rossdonaldson1: /* Special Populations */

2016-09-29T20:21:41Z

Special Populations

← Revisión anterior		Revisión del 20:21 29 sep 2016
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	==Special Populations==		==Special Populations==
	*Pregnancy Risk Factor: C		*[[Drug ratings in pregnancy\|Pregnancy Risk Factor]]: C

	===Renal Dosing===		===Renal Dosing===

Rossdonaldson1: /* Pediatric Dosing */

2016-09-29T20:21:11Z

Pediatric Dosing

← Revisión anterior		Revisión del 20:21 29 sep 2016
Línea 35:		Línea 35:

	==Pediatric Dosing==		==Pediatric Dosing==
	*~~Edema:~~ 1-3.3mg/kg/day PO divided qd-qid		===Edema===
			*1-3.3mg/kg/day PO divided qd-qid
	**Max: 3.3mg/kg/day up to 200mg/day		**Max: 3.3mg/kg/day up to 200mg/day
	**Off label use		**Off label use

	*Hyperaldosteronism test: 125-375mg/m^2/day PO divided bid-qid		===Hyperaldosteronism test===
			*125-375mg/m^2/day PO divided bid-qid
	**Max: 375mg/m^2/day		**Max: 375mg/m^2/day
	**Off label use		**Off label use

Rossdonaldson1: /* Adult Dosing */

2016-09-29T20:20:32Z

Adult Dosing

← Revisión anterior		Revisión del 20:20 29 sep 2016
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	==Adult Dosing==		==Adult Dosing==
	*~~Edema:~~ 25-200mg/day PO divided qd-bid		===Edema===
	**For edema associated with CHF, cirrhosis, or nephrotic syndrome		*25-200mg/day PO divided qd-bid
			**For edema associated with [[CHF]], [[cirrhosis]], or [[nephrotic syndrome]]

	*~~hypertension:~~ 25-50mg/day PO divided qd-bid		===[[Hypertension]]===
			*25-50mg/day PO divided qd-bid
	**Start: 12.5mg PO qd		**Start: 12.5mg PO qd

	*Hyperaldosteronism, primary: 100-400mg PO qd		===Hyperaldosteronism, primary===
			*100-400mg PO qd

	*Hypokalemia, diuretic-induced: 25-100mg/day PO divided qd-qid		===[[Hypokalemia]], diuretic-induced===
			*25-100mg/day PO divided qd-qid

	*[[CHF]], NYHA Class III/IV: 25mg PO qd		===[[CHF]], NYHA Class III/IV===
			*25mg PO qd
	**Use with standard treatment; may increase to 50mg/day after 8wk for worsening CHF if K stable		**Use with standard treatment; may increase to 50mg/day after 8wk for worsening CHF if K stable
	**May decrease to 25mg qod if hyperkalemia; hold if K >5 mEq/L or creatinine >4mg/dL		**May decrease to 25mg qod if hyperkalemia; hold if K >5 mEq/L or creatinine >4mg/dL

	*Hirsutism, idiopathic: 50-200mg PO qd		===Hirsutism, idiopathic===
			*50-200mg PO qd
	**Off label use		**Off label use

	*Acne vulgaris: 50-200mg PO qd		===Acne vulgaris===
			*50-200mg PO qd
	**Start: 25mg PO qd		**Start: 25mg PO qd
	**Off label use		**Off label use

Rossdonaldson1 at 20:17, 29 September 2016

2016-09-29T20:17:05Z

← Revisión anterior		Revisión del 20:17 29 sep 2016
Línea 1:		Línea 1:
	==Administration==		==Administration==
	*Type: Antihypertensive; ~~Potassium Sparing Diuretic~~; ~~Aldosterone Receptor Antagonist~~		*Type: [[Antihypertensive]]; [[potassium sparing diuretic]]; aldosterone receptor antagonist
	*Dosage Forms: 25,50,100		*Dosage Forms: 25,50,100
	*Routes of Administration: Oral		*Routes of Administration: Oral

Rossdonaldson1: Text replacement - "CHF" to "CHF"

2016-09-24T17:59:45Z

Text replacement - "*CHF" to "*CHF"

← Revisión anterior		Revisión del 17:59 24 sep 2016
Línea 16:		Línea 16:
	*Hypokalemia, diuretic-induced: 25-100mg/day PO divided qd-qid		*Hypokalemia, diuretic-induced: 25-100mg/day PO divided qd-qid

	*CHF, NYHA Class III/IV: 25mg PO qd		*[[CHF]], NYHA Class III/IV: 25mg PO qd
	**Use with standard treatment; may increase to 50mg/day after 8wk for worsening CHF if K stable		**Use with standard treatment; may increase to 50mg/day after 8wk for worsening CHF if K stable
	**May decrease to 25mg qod if hyperkalemia; hold if K >5 mEq/L or creatinine >4mg/dL		**May decrease to 25mg qod if hyperkalemia; hold if K >5 mEq/L or creatinine >4mg/dL

Neil.m.young: Text replacement - "Cr " to "creatinine "

2016-08-11T07:55:36Z

Text replacement - "Cr " to "creatinine "

← Revisión anterior		Revisión del 07:55 11 ago 2016
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	*CHF, NYHA Class III/IV: 25mg PO qd		*CHF, NYHA Class III/IV: 25mg PO qd
	**Use with standard treatment; may increase to 50mg/day after 8wk for worsening CHF if K stable		**Use with standard treatment; may increase to 50mg/day after 8wk for worsening CHF if K stable
	**May decrease to 25mg qod if hyperkalemia; hold if K >5 mEq/L or Cr >4mg/dL		**May decrease to 25mg qod if hyperkalemia; hold if K >5 mEq/L or creatinine >4mg/dL

	*Hirsutism, idiopathic: 50-200mg PO qd		*Hirsutism, idiopathic: 50-200mg PO qd