Spiramycin - Revision history

Danbot: Restore original dosing content alongside dynamic SMW tables

2026-03-20T02:37:51Z

Restore original dosing content alongside dynamic SMW tables

← Revisión anterior		Revisión del 02:37 20 mar 2026
Línea 6:		Línea 6:

	==Adult Dosing==		==Adult Dosing==
			*1-2g PO BID OR 500-1000mg PO TID. May increase to 2-2.5g BID for severe infections
			*[[Toxoplasmosis]] in pregnant women:
			**1st trimester: 3g PO daily in 3-4 divided doses
			**2nd/3rd trimesters: 25-50mg [[pyrimethamine]] PO daily AND 2-3g [[sulfadiazine]] daily AND folinic acid 5mg daily for 3 weeks, alternating with 1g PO spiramycin TID for 3 weeks


	===Indications by Disease===		===Indications by Disease===
	{{#ask: [[Has DrugName::Spiramycin]] [[Has Population::Adult]]		{{#ask: [[Has DrugName::Spiramycin]] [[Has Population::Adult]]
	\|?Treats disease=Disease		\|?Treats disease=Disease
	\|?Has Dose=Dose		\|?Has Dose=Dose
	\|?Has Context=Context		\|?Has Context=Context
	\|format=table		\|format=table
	\|limit=50		\|limit=50
	\|mainlabel=-		\|mainlabel=-
	\|headers=show		\|headers=show
	\|sort=Treats disease		\|sort=Treats disease
	}}		}}

	==Pediatric Dosing==		==Pediatric Dosing==
			*>20kg: 25mg/kg PO BID or 16.7mg/kg PO TID
			*Subclinical congenital toxoplasmosis: 0.5-1mg/kg PO daily [[pyrimethamine]] AND 50-100mg/kg PO daily [[sulfadiazine]] x 4 weeks, alternating with 50-100mg/kg spiramycin x 6 weeks, alternating courses for 1 year
			*Overt congenital toxoplasmosis: 0.5mg/kg PO [[pyrimethamine]] daily AND 50-100mg/kg [[sulfadiazine]] PO daily AND 5mg folinic acid q3d for 6 months, alternating with 50-100mg/kg spiramycin AND pyrimethamine AND sulfadiazine for 4 weeks. Repeat dosing courses x 18mo


	===Indications by Disease===		===Indications by Disease===
	{{#ask: [[Has DrugName::Spiramycin]] [[Has Population::Pediatric]]		{{#ask: [[Has DrugName::Spiramycin]] [[Has Population::Pediatric]]
	\|?Treats disease=Disease		\|?Treats disease=Disease
	\|?Has Dose=Dose		\|?Has Dose=Dose
	\|?Has Context=Context		\|?Has Context=Context
	\|format=table		\|format=table
	\|limit=50		\|limit=50
	\|mainlabel=-		\|mainlabel=-
	\|headers=show		\|headers=show
	\|sort=Treats disease		\|sort=Treats disease
	}}		}}

Danbot: Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

2026-03-20T01:53:45Z

Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

← Revisión anterior		Revisión del 01:53 20 mar 2026
Línea 6:		Línea 6:

	==Adult Dosing==		==Adult Dosing==
	*1-2g PO BID OR 500-1000mg PO TID. May increase to 2-2.5g BID for severe infections		===Indications by Disease===
	*[[~~Toxoplasmosis]] in pregnant women~~:		{{#ask: [[Has DrugName::Spiramycin]] [[Has Population::Adult]]
	**1st trimester: ~~3g PO daily in 3-4 divided doses~~		\|?Treats disease=Disease
	**2nd/3rd trimesters: 25-50mg [[pyrimethamine]] ~~PO daily AND 2-3g~~ [[~~sulfadiazine~~]] ~~daily AND folinic acid 5mg daily for 3 weeks, alternating with 1g PO spiramycin TID for 3 weeks~~		\|?Has Dose=Dose
			\|?Has Context=Context
			\|format=table
			\|limit=50
			\|mainlabel=-
			\|headers=show
			\|sort=Treats disease
			}}

	==Pediatric Dosing==		==Pediatric Dosing==
	*>20kg: 25mg/kg PO BID or 16.7mg/kg PO TID		===Indications by Disease===
	*Subclinical congenital toxoplasmosis: ~~0.5-1mg/kg PO daily~~ [[~~pyrimethamine~~]] ~~AND 50-100mg/kg PO daily~~ [[~~sulfadiazine~~]] ~~x 4 weeks, alternating with~~ 50-~~100mg/kg spiramycin x 6 weeks, alternating courses for 1 year~~		{{#ask: [[Has DrugName::Spiramycin]] [[Has Population::Pediatric]]
	*Overt congenital toxoplasmosis: 0.5mg/kg PO [[pyrimethamine]] daily AND 50-100mg/kg [[sulfadiazine]] PO daily AND 5mg folinic acid q3d for 6 months, alternating with 50-100mg/kg spiramycin AND pyrimethamine AND sulfadiazine for 4 weeks. Repeat dosing courses x 18mo		\|?Treats disease=Disease
			\|?Has Dose=Dose
			\|?Has Context=Context
			\|format=table
			\|limit=50
			\|mainlabel=-
			\|headers=show
			\|sort=Treats disease
			}}

	==Special Populations==		==Special Populations==

Ihearttroponin at 02:21, 5 March 2020

2020-03-05T02:21:07Z

← Revisión anterior		Revisión del 02:21 5 mar 2020
Línea 1:		Línea 1:
	==Administration==		==Administration==
	*Type: [[macrolide]] antibiotic		*Type: [[macrolide]] antibiotic
	*Dosage Forms:		*Dosage Forms: 250, 500
	*Routes of Administration: PO, IV		*Routes of Administration: PO, IV
	*Common Trade Names:		*Common Trade Names: Rovamycine

	==Adult Dosing==		==Adult Dosing==
Línea 20:		Línea 20:
	*Category B, Safe in pregnancy<ref>Stray-Pedersen B. Treatment of toxoplasmosis in the pregnant mother and newborn child. Scand J Infect Dis 1992; 84(suppl): 23-31</ref>		*Category B, Safe in pregnancy<ref>Stray-Pedersen B. Treatment of toxoplasmosis in the pregnant mother and newborn child. Scand J Infect Dis 1992; 84(suppl): 23-31</ref>

	===Lactation risk===		===[[Lactation risk]]===
	*Distributed in breast milk		*Distributed in breast milk

	===Renal Dosing===		===Renal Dosing===
	*Adult:		*Adult: n/a
	*Pediatric:		*Pediatric: n/a

	===Hepatic Dosing===		===Hepatic Dosing===
Línea 38:		Línea 38:
	*Thrombocytopenia		*Thrombocytopenia
	*Cholestatic hepatitis		*Cholestatic hepatitis
	*GI toxicity, specifically acute colitis or other intestinal injury		*GI toxicity, specifically acute colitis, C. diff colitis, or other intestinal injury
	*Ulcerated esophagitis		*Ulcerated esophagitis
			*Worsening hepatic impairment in patients with pre-existing liver disease

	===Common===		===Common===
Línea 46:		Línea 47:

	==Pharmacology==		==Pharmacology==
	*Half-life: 4.5-13.5h		*Half-life: 4.5-13.5h (increases with increasing age)
	*Metabolism: Hepatic		*Metabolism: Hepatic
	*Excretion: Fecal		*Excretion: Fecal (predominant), renal

	==Mechanism of Action==		==Mechanism of Action==
	*Reversibly binds to the 50 S subunit of bacterial ribosomes, resulting in blockage of the transpeptidation or translocation reactions, inhibiting protein synthesis and subsequent cell growth		*Reversibly binds to the 50 S subunit of bacterial ribosomes, resulting in blockage of the transpeptidation or translocation reactions, inhibiting protein synthesis and subsequent cell growth<ref>Rovamycine (spiramycin) [product monograph]. Quebec, Canada: Aventis Pharma Inc; April 2018.</ref>

	==Comments==		==Comments==
	*Not approved in US for standard use, though exceptions can be made to treat toxoplasmosis in pregnant women		*Not approved in US for standard use, though exceptions can be made to treat toxoplasmosis in pregnant women<ref>Spiramycin. Lexicomp. http://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/7697?searchUrl=%2Flco%2Faction%2Fsearch%3Forigin%3Dapi%26t%3Dglobalid%26q%3D6982%26nq%3Dtrue. Accessed March 5, 2020.</ref>

	==See Also==		==See Also==
	*[[Toxoplasmosis]]		*[[Toxoplasmosis]]
			*[[Macrolide]]

	==References==		==References==

ClaireLewis: /* Pregnancy Rating */

2019-09-23T22:34:24Z

Pregnancy Rating

← Revisión anterior		Revisión del 22:34 23 sep 2019
Línea 18:		Línea 18:
	==Special Populations==		==Special Populations==
	===[[Drug pregnancy categories\|Pregnancy Rating]]===		===[[Drug pregnancy categories\|Pregnancy Rating]]===
	*Safe in pregnancy<ref>Stray-Pedersen B. Treatment of toxoplasmosis in the pregnant mother and newborn child. Scand J Infect Dis 1992; 84(suppl): 23-31</ref>		*Category B, Safe in pregnancy<ref>Stray-Pedersen B. Treatment of toxoplasmosis in the pregnant mother and newborn child. Scand J Infect Dis 1992; 84(suppl): 23-31</ref>

	===Lactation risk===		===Lactation risk===

ClaireLewis: Created page with "==Administration== Type: macrolide antibiotic Dosage Forms: Routes of Administration: PO, IV Common Trade Names: ==Adult Dosing== *1-2g PO BID OR 500-1000mg PO TID...."

2019-09-03T16:33:07Z

Created page with "==Administration== *Type: macrolide antibiotic *Dosage Forms: *Routes of Administration: PO, IV *Common Trade Names: ==Adult Dosing== *1-2g PO BID OR 500-1000mg PO TID...."

Página nueva

==Administration==
*Type: [[macrolide]] antibiotic
*Dosage Forms:
*Routes of Administration: PO, IV
*Common Trade Names:

==Adult Dosing==
*1-2g PO BID OR 500-1000mg PO TID. May increase to 2-2.5g BID for severe infections
*[[Toxoplasmosis]] in pregnant women:
**1st trimester: 3g PO daily in 3-4 divided doses
**2nd/3rd trimesters: 25-50mg [[pyrimethamine]] PO daily AND 2-3g [[sulfadiazine]] daily AND folinic acid 5mg daily for 3 weeks, alternating with 1g PO spiramycin TID for 3 weeks

==Pediatric Dosing==
*>20kg: 25mg/kg PO BID or 16.7mg/kg PO TID
*Subclinical congenital toxoplasmosis: 0.5-1mg/kg PO daily [[pyrimethamine]] AND 50-100mg/kg PO daily [[sulfadiazine]] x 4 weeks, alternating with 50-100mg/kg spiramycin x 6 weeks, alternating courses for 1 year
*Overt congenital toxoplasmosis: 0.5mg/kg PO [[pyrimethamine]] daily AND 50-100mg/kg [[sulfadiazine]] PO daily AND 5mg folinic acid q3d for 6 months, alternating with 50-100mg/kg spiramycin AND pyrimethamine AND sulfadiazine for 4 weeks. Repeat dosing courses x 18mo

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*Safe in pregnancy<ref>Stray-Pedersen B. Treatment of toxoplasmosis in the pregnant mother and newborn child. Scand J Infect Dis 1992; 84(suppl): 23-31</ref>

===Lactation risk===
*Distributed in breast milk

===Renal Dosing===
*Adult:
*Pediatric:

===Hepatic Dosing===
*Caution in hepatic impairment

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Cardiac toxicity, specifically QT prolongation
*Thrombocytopenia
*Cholestatic hepatitis
*GI toxicity, specifically acute colitis or other intestinal injury
*Ulcerated esophagitis

===Common===
*Injection site pain
*Nausea/vomiting, diarrhea, abdominal pain

==Pharmacology==
*Half-life: 4.5-13.5h
*Metabolism: Hepatic
*Excretion: Fecal

==Mechanism of Action==
*Reversibly binds to the 50 S subunit of bacterial ribosomes, resulting in blockage of the transpeptidation or translocation reactions, inhibiting protein synthesis and subsequent cell growth

==Comments==
*Not approved in US for standard use, though exceptions can be made to treat toxoplasmosis in pregnant women

==See Also==
*[[Toxoplasmosis]]

==References==
<references/>

[[Category:Pharmacology]]

Spiramycin - Revision history

Danbot: Restore original dosing content alongside dynamic SMW tables

Danbot: Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

Ihearttroponin at 02:21, 5 March 2020

ClaireLewis: /* Pregnancy Rating */

ClaireLewis: Created page with "==Administration== *Type: macrolide antibiotic *Dosage Forms: *Routes of Administration: PO, IV *Common Trade Names: ==Adult Dosing== *1-2g PO BID OR 500-1000mg PO TID...."

ClaireLewis: Created page with "==Administration== Type: macrolide antibiotic Dosage Forms: Routes of Administration: PO, IV Common Trade Names: ==Adult Dosing== *1-2g PO BID OR 500-1000mg PO TID...."