Sotalol - Revision history

Elcatracho: /* See Also */

2021-03-07T01:20:23Z

Elcatracho: /* See Also */

2021-02-20T20:27:07Z

Elcatracho: /* Contraindications */

2021-02-20T20:26:44Z

Contraindications

← Revisión anterior		Revisión del 20:26 20 feb 2021
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	*Congenital or acquired [[QT prolongation]]		*Congenital or acquired [[QT prolongation]]
	*Baseline QTc > 450 msec		*Baseline QTc > 450 msec
	*Decompensated heart failure		*Decompensated [[heart failure]]
	*[[Cardiogenic shock]]		*[[Cardiogenic shock]]
	*CrCl < 40 (IV use)		*CrCl < 40 (IV use)

ClaireLewis at 22:31, 23 September 2019

2019-09-23T22:31:42Z

← Revisión anterior		Revisión del 22:31 23 sep 2019
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	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: Caution advised (esp in 2nd and 3rd trimester)		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: Category B Caution advised (esp in 2nd and 3rd trimester)
	*Lactation: Possibly unsafe		*Lactation: Possibly unsafe
	*Renal Dosing		*Renal Dosing
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	*Congenital or acquired [[QT prolongation]]		*Congenital or acquired [[QT prolongation]]
	*Baseline QTc > 450 msec		*Baseline QTc > 450 msec
	*~~Deompensated~~ heart failure		*Decompensated heart failure
	*[[Cardiogenic shock]]		*[[Cardiogenic shock]]
	*CrCl < 40 (IV use)		*CrCl < 40 (IV use)
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	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:Cardiology]]

Rossdonaldson1: Text replacement - "BSA" to "BSA"

2019-02-12T07:13:16Z

Text replacement - "BSA" to "BSA"

← Revisión anterior		Revisión del 07:13 12 feb 2019
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	===Ventricular arrhythmia, life-threatening===		===Ventricular arrhythmia, life-threatening===
	*<2 yo		*<2 yo
	**Dose based on BSA and age-specific factor		**Dose based on [[BSA]] and age-specific factor
	*2+ yo, PO		*2+ yo, PO
	**90-180 mg/m^2/day PO divided TID		**90-180 mg/m^2/day PO divided TID

Jonwarren: Updated information.

2017-08-10T16:19:19Z

Updated information.

← Revisión anterior		Revisión del 16:19 10 ago 2017
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	==General==		==General==
	*Type: [[Beta blockers]]		*Type: [[Beta blockers]]
	*Dosage Forms:		*Dosage Forms: Tab (80 mg, 120 mg, 160 mg, 240 mg); Injection
	*Common Trade Names:		*Common Trade Names: Sotalol

	==Adult Dosing==		==Adult Dosing==
	*80mg PO ~~BID~~		===Ventricular arrhythmia, life-threatening===
			*80-160 mg PO q12h
			**Start: 80mg PO q 12h
			**Max: 640 mg/day
			**Taper over 1-2wk to D/C
			*75-150 mg IV q12h
			**Start: 75 mg IV q12h
			**Max: 600 mg/day
			**Taper over 1-2wk to D/C

	==Pediatric Dosing==		==Pediatric Dosing==
			===Ventricular arrhythmia, life-threatening===
			*<2 yo
			**Dose based on BSA and age-specific factor
			*2+ yo, PO
			**90-180 mg/m^2/day PO divided TID
			***Start: 90mg/m^2/day
			***Max: 180mg/m^2/day
			*2+ yo, IV
			**84-168mg/m^2/day IV divided TID
			***Start: 84mg/m^2/day
			***Max: 168mg/m^2/day

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]:		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: Caution advised (esp in 2nd and 3rd trimester)
	*Lactation:		*Lactation: Possibly unsafe
	*Renal Dosing		*Renal Dosing
	**Adult		**Adult
			***CrCl 30-59: Give q24h
			***CrCl 10-29: Give q36-48h
			***CrCl <10: Individualize Dose
			***IV drug contraindicated with CrCl <40
	**Pediatric		**Pediatric
			***Not defined
	*Hepatic Dosing		*Hepatic Dosing
	**Adult		**Adult
			***No Adjustment
	**Pediatric		**Pediatric
			***No Adjustment

	==Indications==		==Indications==
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	==Contraindications==		==Contraindications==
	*Allergy to class/drug		*Allergy to class/drug
			*[[Sinus bradycardia]]
			*[[Sick sinus syndrome]] w/o pacemaker
			*2nd or 3rd Degree [[AV block]] w/o pacemaker
			*Congenital or acquired [[QT prolongation]]
			*Baseline QTc > 450 msec
			*Deompensated heart failure
			*[[Cardiogenic shock]]
			*CrCl < 40 (IV use)
			*Bronchospastic disorders

	==Adverse Reactions==		==Adverse Reactions==
	*Hypotension~~, bradycardia~~		===Serious===
			*[[Hypotension]]
			*[[Bradycardia]]
	*Proarrhythmia (esp in patients with [[hypokalemia]])		*Proarrhythmia (esp in patients with [[hypokalemia]])
			*[[Congestive heart failure]]
			*[[QT Prolongation]]
			*[[Torsades de pointes]]
			*[[Lupus erythematosus]]
			===Common===
			*[[Fatigue]]
			*Dizziness
			*[[Nausea]]/[[Vomiting]]
			*[[Diarrhea]]
			*Asthenia
			*Hyperhidrosis
			*[[Palpitations]]
			*[[Headache]]
			*Insomnia
			*[[Dyspepsia]]
			*Edema


	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 12h
	*Metabolism:		*Metabolism: None
	*Excretion:		*Excretion: Urine
	*Mechanism of Action:		*Mechanism of Action:
	**Class II - Nonselective beta-blocker		**Class II - Nonselective beta-blocker

Mholtz at 06:39, 13 July 2017

2017-07-13T06:39:26Z

← Revisión anterior		Revisión del 06:39 13 jul 2017
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	==References==		==References==
			<references/>

	~~<references/>~~
	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Neil.m.young: Text replacement - "== " to "=="

2016-07-09T17:04:42Z

Text replacement - "== " to "=="

← Revisión anterior		Revisión del 17:04 9 jul 2016
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	**Pediatric		**Pediatric

	== Indications==		==Indications==
	*Suppression of ventricular arrhythmias refractory to other meds		*Suppression of ventricular arrhythmias refractory to other meds
	*Suppression of SVT, a-fib		*Suppression of SVT, a-fib

Neil.m.young: Text replacement - " ==" to "=="

2016-07-06T17:19:07Z

Text replacement - " ==" to "=="

← Revisión anterior		Revisión del 17:19 6 jul 2016
Línea 19:		Línea 19:
	**Pediatric		**Pediatric

	== Indications ==		== Indications==
	*Suppression of ventricular arrhythmias refractory to other meds		*Suppression of ventricular arrhythmias refractory to other meds
	*Suppression of SVT, a-fib		*Suppression of SVT, a-fib

Neil.m.young: Text replacement - "==Sources==" to "==References=="

2016-06-26T21:17:55Z

Text replacement - "==Sources==" to "==References=="

← Revisión anterior		Revisión del 21:17 26 jun 2016
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	*[[Antiarrhythmics]]		*[[Antiarrhythmics]]

	==~~Sources~~==		==References==

	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]

← Revisión anterior		Revisión del 01:20 7 mar 2021
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	==See Also==		==See Also==
			*[[Beta-blockers]]
			*[[Beta-blocker toxicity]]
	*[[Antiarrhythmics]]		*[[Antiarrhythmics]]
	*[[~~Beta blockers~~]]		*[[Antihypertensive medications]]

	==References==		==References==

← Revisión anterior		Revisión del 20:27 20 feb 2021
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	==See Also==		==See Also==
	*[[Antiarrhythmics]]		*[[Antiarrhythmics]]
			*[[Beta blockers]]

	==References==		==References==