Sarcoidosis - Revision history

Elcatracho: /* Clinical Features */

2021-02-01T20:25:52Z

Clinical Features

← Revisión anterior		Revisión del 20:25 1 feb 2021
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	==Clinical Features==		==Clinical Features==
	[[File:PMC3505767 ad-24-383-g009.png\|thumb\|Sarcoidosis. (A) Subcutaneous nodules without changes in overlying epidermis. (B) Characteristic non-caseating granuloma with giant cell.]]		[[File:PMC3505767 ad-24-383-g009.png\|thumb\|Sarcoidosis. (A) Subcutaneous nodules without changes in overlying epidermis. (B) Characteristic non-caseating granuloma with giant cell.]]
			[[File:Lupus_pernio.jpg\|thumb\|Lupus pernio is pathognomonic for sarcoidosis]]
	''Depend on location of granulomata. May be entirely asymptomatic.''		''Depend on location of granulomata. May be entirely asymptomatic.''
	*Respiratory		*Respiratory

Elcatracho: /* Clinical Features */

2021-02-01T20:24:21Z

Clinical Features

← Revisión anterior		Revisión del 20:24 1 feb 2021
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	**[[Pneumothorax]]		**[[Pneumothorax]]
	*[[Erythema nodosum]] and other skin lesions		*[[Erythema nodosum]] and other skin lesions
			**[[Lupus pernio]] is pathognomonic for sarcoidosis and the most specific physical exam finding<ref>James WD, Berger TG, Elston DM. Macrophage/Monocyte Disorders. In: James WD, Berger TG, Elston DM (eds). Andrews’ Diseases of the Skin, 12e. Philadelphia, PA: Elsevier; 2016, Chapter 31.</ref>
	*Fatigue		*Fatigue
	*Weight loss		*Weight loss
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	**[[Optic neuritis]]		**[[Optic neuritis]]
	**[[Iritis]]		**[[Iritis]]


	==Differential Diagnosis==		==Differential Diagnosis==

Rossdonaldson1 at 16:58, 9 September 2020

2020-09-09T16:58:41Z

← Revisión anterior		Revisión del 16:58 9 sep 2020
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	**Exact cause unknown - thought to be related to an immune reaction to a prior insult such as infection or chemical exposure earlier in life.		**Exact cause unknown - thought to be related to an immune reaction to a prior insult such as infection or chemical exposure earlier in life.
	**Do not confuse with infectious granulomatous processes such as [[tuberculosis]].		**Do not confuse with infectious granulomatous processes such as [[tuberculosis]].

	~~[[File:SarcoidXray.png\|thumb\|Sarcoid Xray - hilar adenopathy]]~~

	==Clinical Features==		==Clinical Features==
			[[File:PMC3505767 ad-24-383-g009.png\|thumb\|Sarcoidosis. (A) Subcutaneous nodules without changes in overlying epidermis. (B) Characteristic non-caseating granuloma with giant cell.]]
	''Depend on location of granulomata. May be entirely asymptomatic.''		''Depend on location of granulomata. May be entirely asymptomatic.''
	*Respiratory		*Respiratory
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	*[[Polymyalgia rheumatica]]		*[[Polymyalgia rheumatica]]

	==~~Workup~~==		==Evaluation==
			[[File:SarcoidXray.png\|thumb\|Sarcoid Xray - hilar adenopathy]]
	*Definitive initial diagnosis unlikely to be made in ED, but may be suggested by typical granulomatous lesions seen on CT or other imaging in setting of appropriate clinical context		*Definitive initial diagnosis unlikely to be made in ED, but may be suggested by typical granulomatous lesions seen on CT or other imaging in setting of appropriate clinical context
	*Evaluate for complications/alternative diagnoses of presenting symptoms		*Evaluate for complications/alternative diagnoses of presenting symptoms
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	==Disposition==		==Disposition==
	*~~Dependant~~ on presentation		*Dependent on presentation

	==See Also==		==See Also==

ClaireLewis at 18:20, 13 October 2019

2019-10-13T18:20:21Z

← Revisión anterior		Revisión del 18:20 13 oct 2019
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	**[[Cough]]		**[[Cough]]
	**[[Pulmonary hypertension]]		**[[Pulmonary hypertension]]
	**Pulmonary abscesses/[[empyema]]		**[[lung abscess\|Pulmonary abscesses]]/[[empyema]]
	**[[Pneumothorax]]		**[[Pneumothorax]]
	*Erythema nodosum and other skin lesions		*[[Erythema nodosum]] and other skin lesions
	*Fatigue		*Fatigue
	*Weight loss		*Weight loss
	*~~Arthralgias~~		*[[Arthralgia]]s
	*Cardiopulmonary		*Cardiopulmonary
	**[[Restrictive cardiomyopathy]]		**[[Restrictive cardiomyopathy]]
	**~~Arrythmias~~ due to conduction disturbance		**[[Arrhythmias]] due to conduction disturbance
	*Endocrine		*Endocrine
	**[[Hypercalcemia]]		**[[Hypercalcemia]]
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	**[[Adrenal insufficiency]]		**[[Adrenal insufficiency]]
	*Ocular		*Ocular
	**Dacryoadenitis (lacrimal duct inflammation)		**[[Dacryoadenitis]] (lacrimal duct inflammation)
	**Optic neuritis		**[[Optic neuritis]]
	**Iritis		**[[Iritis]]

ClaireLewis at 15:22, 18 August 2019

2019-08-18T15:22:01Z

← Revisión anterior		Revisión del 15:22 18 ago 2019
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	==Workup==		==Workup==
			*Definitive initial diagnosis unlikely to be made in ED, but may be suggested by typical granulomatous lesions seen on CT or other imaging in setting of appropriate clinical context
			*Evaluate for complications/alternative diagnoses of presenting symptoms

	==Management==		==Management==
			*[[Corticosteroids]]
			*Treat complications

	==Disposition==		==Disposition==
			*Dependant on presentation

	==See Also==		==See Also==

ClaireLewis: /* Differential Diagnosis */

2019-08-18T15:18:00Z

Differential Diagnosis

← Revisión anterior		Revisión del 15:18 18 ago 2019
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	*[[Churg-Strauss syndrome]]		*[[Churg-Strauss syndrome]]
	*[[Lupus]]		*[[Lupus]]
	*Rheumatoid arthritis		*[[Rheumatoid arthritis]]
	*Polymyalgia rheumatica		*[[Polymyalgia rheumatica]]

	==Workup==		==Workup==

Aganapathy: /* Background */

2018-01-22T22:52:15Z

Background

← Revisión anterior		Revisión del 22:52 22 ene 2018
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	==Background==		==Background==
	*Abnormal collection of inflammatory cells (~~grandulomas~~) throughout the body.		*Abnormal collection of inflammatory cells (granulomas) throughout the body.
	**Most common location for granulomas to occur are the lung, skin, heart, and brain.		**Most common location for granulomas to occur are the lung, skin, heart, and brain.
	**Exact cause unknown - thought to be related to an immune reaction to a prior insult such as infection or chemical exposure earlier in life.		**Exact cause unknown - thought to be related to an immune reaction to a prior insult such as infection or chemical exposure earlier in life.

ClaireLewis at 03:54, 5 October 2016

2016-10-05T03:54:37Z

← Revisión anterior		Revisión del 03:54 5 oct 2016
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	*Malignancy		*Malignancy
	*[[Tuberculosis]]		*[[Tuberculosis]]
	*[[~~Coccidiodomycosis~~]]		*[[Coccidioidomycosis]]
	*Histiocytosis X		*Histiocytosis X
	*Wegener's granulomatosis		*[[Wegener's granulomatosis]]
	*Churg-Strauss syndrome		*[[Churg-Strauss syndrome]]
	*[[Lupus]]		*[[Lupus]]
	*Rheumatoid arthritis		*Rheumatoid arthritis

ClaireLewis at 01:22, 6 September 2016

2016-09-06T01:22:58Z

← Revisión anterior		Revisión del 01:22 6 sep 2016
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	**Most common location for granulomas to occur are the lung, skin, heart, and brain.		**Most common location for granulomas to occur are the lung, skin, heart, and brain.
	**Exact cause unknown - thought to be related to an immune reaction to a prior insult such as infection or chemical exposure earlier in life.		**Exact cause unknown - thought to be related to an immune reaction to a prior insult such as infection or chemical exposure earlier in life.
	**Do not confuse with infectious granulomatous processes such as [[~~pulmonary~~ tuberculosis]].		**Do not confuse with infectious granulomatous processes such as [[tuberculosis]].

	[[File:SarcoidXray.png\|thumb\|Sarcoid Xray - hilar adenopathy]]		[[File:SarcoidXray.png\|thumb\|Sarcoid Xray - hilar adenopathy]]

	==Clinical Features==		==Clinical Features==
			''Depend on location of granulomata. May be entirely asymptomatic.''
			*Respiratory
			**Due to pulmonary granulomata
			**[[Shortness of breath]]
			**[[Cough]]
			**[[Pulmonary hypertension]]
			**Pulmonary abscesses/[[empyema]]
			**[[Pneumothorax]]
			*Erythema nodosum and other skin lesions
	*Fatigue		*Fatigue
	*Weight loss		*Weight loss
	*Arthralgias		*Arthralgias
	*~~Blurry vision~~		*Cardiopulmonary
	*~~Shortness of breath~~		**[[Restrictive cardiomyopathy]]
	*~~Cough~~		**Arrythmias due to conduction disturbance
	*~~Skin lesions~~		*Endocrine
	*~~Asymptomatic~~ (~~about 5% of cases~~)		**[[Hypercalcemia]]
			**[[Hypothyroidism]]
			**[[Adrenal insufficiency]]
			*Ocular
			**Dacryoadenitis (lacrimal duct inflammation)
			**Optic neuritis
			**Iritis


	==Differential Diagnosis==		==Differential Diagnosis==
	*Malignancy		*Malignancy
	*Tuberculosis		*[[Tuberculosis]]
	*Coccidiodomycosis		*[[Coccidiodomycosis]]
	*Histiocytosis X		*Histiocytosis X
	*Wegener's granulomatosis		*Wegener's granulomatosis
	*Churg-Strauss syndrome		*Churg-Strauss syndrome
	*Lupus		*[[Lupus]]
	*Rheumatoid arthritis		*Rheumatoid arthritis
	*Polymyalgia rheumatica		*Polymyalgia rheumatica

Mholtz at 22:05, 1 September 2016

2016-09-01T22:05:53Z

← Revisión anterior		Revisión del 22:05 1 sep 2016
Línea 1:		Línea 1:
	==Background==		==Background==
	~~Sarcoidosis is the abnormal~~ collection of inflammatory cells ~~called [[~~grandulomas]] throughout the body. ~~The most~~ common location for ~~these~~ granulomas to occur are the lung, skin, heart, and brain. ~~The exact~~ cause ~~of sarcoidosis is not known, however it is~~ thought to be related to an immune reaction to a prior insult such as infection or chemical exposure earlier in life. ~~This is~~ not ~~to be confused~~ with a infectious granulomatous processes such as [[pulmonary tuberculosis]].		*Abnormal collection of inflammatory cells (grandulomas) throughout the body.
			**Most common location for granulomas to occur are the lung, skin, heart, and brain.
			**Exact cause unknown - thought to be related to an immune reaction to a prior insult such as infection or chemical exposure earlier in life.
			**Do not confuse with infectious granulomatous processes such as [[pulmonary tuberculosis]].

	[[File:SarcoidXray.png\|thumb\|Sarcoid Xray - hilar adenopathy]]		[[File:SarcoidXray.png\|thumb\|Sarcoid Xray - hilar adenopathy]]

	==Clinical Features==		==Clinical Features==
	~~-fatigue<br />~~		*Fatigue
	~~-weight~~ loss~~<br />~~		*Weight loss
	~~-arthralgias<br />~~		*Arthralgias
	~~-blurry~~ vision~~<br />~~		*Blurry vision
	~~-shortness~~ of breath~~<br />~~		*Shortness of breath
	~~-cough<br />~~		*Cough
	~~-skin~~ lesions~~<br />~~		*Skin lesions
	~~-asymptomatic~~ (about 5% of cases)		*Asymptomatic (about 5% of cases)

	==Differential Diagnosis==		==Differential Diagnosis==
	~~-Cancer<br />~~		*Malignancy
	-Tuberculosis~~<br />~~		*Tuberculosis
	-Coccidiodomycosis~~<br />~~		*Coccidiodomycosis
	-Histiocytosis X~~<br />~~		*Histiocytosis X
	-Wegener's granulomatosis~~<br />~~		*Wegener's granulomatosis
	-Churg-Strauss syndrome~~<br />~~		*Churg-Strauss syndrome
	-Lupus~~<br />~~		*Lupus
	-Rheumatoid arthritis~~<br />~~		*Rheumatoid arthritis
	-Polymyalgia rheumatica		*Polymyalgia rheumatica

	==Workup==		==Workup==


	==Management==		==Management==


	==Disposition==		==Disposition==


	==See Also==		==See Also==


	==External Links==		==External Links==


	==References==		==References==