Ritonavir - Revision history

Ihearttroponin: Removed redirect to Lopinavir

2020-03-22T19:07:57Z

Removed redirect to Lopinavir

← Revisión anterior		Revisión del 19:07 22 mar 2020
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	~~#REDIRECT [[lopinavir]]~~

	==Background==		==Background==
	Ritonavir is usually given in combination with [[lopinavir]] for both treatment of [[HIV]] and [[HIV post-exposure prophylaxis]]. It is currently being studied in the use of [[COVID-19]] as well.		Ritonavir is usually given in combination with [[lopinavir]] for both treatment of [[HIV]] and [[HIV post-exposure prophylaxis]]. It is currently being studied in the use of [[COVID-19]] as well.

Ihearttroponin: Redirected page to Lopinavir

2020-03-22T19:07:20Z

Redirected page to Lopinavir

← Revisión anterior		Revisión del 19:07 22 mar 2020
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			#REDIRECT [[lopinavir]]

	==Background==		==Background==
	Ritonavir is usually given in combination with [[lopinavir]] for both treatment of [[HIV]] and [[HIV post-exposure prophylaxis]]. It is currently being studied in the use of [[COVID-19]] as well.		Ritonavir is usually given in combination with [[lopinavir]] for both treatment of [[HIV]] and [[HIV post-exposure prophylaxis]]. It is currently being studied in the use of [[COVID-19]] as well.

Ihearttroponin: /* Background */

2020-03-22T19:03:43Z

Background

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	==Background==		==Background==
	~~Lopinavir~~ is usually given in combination with [[~~ritonavir~~]] for both treatment of [[HIV]] and [[HIV post-exposure prophylaxis]]. It is currently being studied in the use of [[COVID-19]] as well.		Ritonavir is usually given in combination with [[lopinavir]] for both treatment of [[HIV]] and [[HIV post-exposure prophylaxis]]. It is currently being studied in the use of [[COVID-19]] as well.

	==Administration==		==Administration==

Ihearttroponin at 19:03, 22 March 2020

2020-03-22T19:03:20Z

← Revisión anterior		Revisión del 19:03 22 mar 2020
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	==Background==		==Background==
	Lopinavir is usually given in combination with [[ritonavir]] for both treatment of [[HIV]] and [[HIV]] post-exposure prophylaxis. It is currently being studied in the use of [[COVID-19]] as well.		Lopinavir is usually given in combination with [[ritonavir]] for both treatment of [[HIV]] and [[HIV post-exposure prophylaxis]]. It is currently being studied in the use of [[COVID-19]] as well.

	==Administration==		==Administration==
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	***Start with 300 mg PO BID, increased by 200 mg/day every 2-3 days		***Start with 300 mg PO BID, increased by 200 mg/day every 2-3 days

	*HIV post-exposure prophylaxis		*[[HIV post-exposure prophylaxis]]
	**100 mg PO QID		**100 mg PO QID
	**Part of multi-drug regimen		**Part of multi-drug regimen
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	*HIV Treatment		*HIV Treatment
	**Can be given in >1 month old, dosing varies based on other concominant treatments		**Can be given in >1 month old, dosing varies based on other concominant treatments
	*HIV post-exposure prophylaxis		*[[HIV post-exposure prophylaxis]]
	**Can be given in >3 years old, dosing varies based on other concominant treatments		**Can be given in >3 years old, dosing varies based on other concominant treatments

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	==See Also==		==See Also==
	*[[Lopinavir]]		*[[Lopinavir]]
			*[[HIV]]
			*[[HIV post-exposure prophylaxis]]
	*[[Coronavirus]]		*[[Coronavirus]]
	*[[COVID-19]]		*[[COVID-19]]
	*[[HIV]]

Ihearttroponin at 19:02, 22 March 2020

2020-03-22T19:02:04Z

← Revisión anterior		Revisión del 19:02 22 mar 2020
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			==Background==
			Lopinavir is usually given in combination with [[ritonavir]] for both treatment of [[HIV]] and [[HIV]] post-exposure prophylaxis. It is currently being studied in the use of [[COVID-19]] as well.

	==Administration==		==Administration==
	*Type: [[Antiviral]]		*Type: [[Antiviral]]

Ihearttroponin at 16:53, 22 March 2020

2020-03-22T16:53:05Z

← Revisión anterior		Revisión del 16:53 22 mar 2020
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	==Comments==		==Comments==
	A trial of [[lopinavir]]/[[ritonavir]] is currently being done to study use in [[COVID-19]]. So far, studies have not shown significant benefit in time to clinical improvement. Mortality at 28 days is lower but not statistically significant.		A trial of [[lopinavir]]/[[ritonavir]] is currently being done to study use in [[COVID-19]]. So far, studies have not shown significant benefit in time to clinical improvement. Mortality at 28 days is lower but not statistically significant.<ref>Cao B, Wang Y, Wen D, et al. A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19 [published online ahead of print, 2020 Mar 18]. N Engl J Med. 2020;10.1056/NEJMoa2001282. doi:10.1056/NEJMoa2001282</ref>

	==See Also==		==See Also==
			*[[Lopinavir]]
			*[[Coronavirus]]
			*[[COVID-19]]
			*[[HIV]]

Ihearttroponin at 16:49, 22 March 2020

2020-03-22T16:49:10Z

← Revisión anterior		Revisión del 16:49 22 mar 2020
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	==Adult Dosing==		==Adult Dosing==
	*HIV Treatment		*HIV Treatment
			**Protease inhibitor boosting
			***100-400 mg/day QD-BID
			**Sole protease inhibitor
			***600 mg PO BID
			***Start with 300 mg PO BID, increased by 200 mg/day every 2-3 days

	*HIV post-exposure prophylaxis		*HIV post-exposure prophylaxis
	*		**100 mg PO QID
			**Part of multi-drug regimen

	==Pediatric Dosing==		==Pediatric Dosing==
	*HIV Treatment		*HIV Treatment
			**Can be given in >1 month old, dosing varies based on other concominant treatments
	*HIV post-exposure prophylaxis		*HIV post-exposure prophylaxis
	*		**Can be given in >3 years old, dosing varies based on other concominant treatments

	==Special Populations==		==Special Populations==
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	==Comments==		==Comments==
			A trial of [[lopinavir]]/[[ritonavir]] is currently being done to study use in [[COVID-19]]. So far, studies have not shown significant benefit in time to clinical improvement. Mortality at 28 days is lower but not statistically significant.

	==See Also==		==See Also==

Ihearttroponin at 12:33, 22 March 2020

2020-03-22T12:33:34Z

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	==Mechanism of Action==		==Mechanism of Action==
			*Binds to active site of HIV protease, preventing maturation of the virus

	==Comments==		==Comments==

Ihearttroponin at 12:27, 22 March 2020

2020-03-22T12:27:06Z

← Revisión anterior		Revisión del 12:27 22 mar 2020
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	==Administration==		==Administration==
	*Type:		*Type: [[Antiviral]]
	*Dosage Forms:		*Dosage Forms: 100 mg
	*Routes of Administration:		*Routes of Administration: PO
	*Common Trade Names:		*Common Trade Names: Norvir

	==Adult Dosing==		==Adult Dosing==
			*HIV Treatment
			*HIV post-exposure prophylaxis
			*

	==Pediatric Dosing==		==Pediatric Dosing==
			*HIV Treatment
			*HIV post-exposure prophylaxis
			*

	==Special Populations==		==Special Populations==
	===[[Drug pregnancy categories\|Pregnancy Rating]]===		===[[Drug pregnancy categories\|Pregnancy Rating]]===
	*		*HIV: Benefits outweight risk during pregnancy. Avoid oral solution due to alcohol content.

	===Lactation risk===		===Lactation risk===
	*		*Avoid breastfeeding

	===Renal Dosing===		===Renal Dosing===
	*Adult:		*Adult: No adjustment
	*Pediatric:		*Pediatric: Not defined, but likely no adjustment as in adults

	===Hepatic Dosing===		===Hepatic Dosing===
	*Adult:		*Adult:
			**Mild-moderate impairment: no adjustment
			**Severe impairment: not defined
	*Pediatric:		*Pediatric:
			**Mild-moderate impairment: no adjustment
			**Severe impairment: not defined
	==Contraindications==		==Contraindications==
	*Allergy to class/drug		*Allergy to class/drug
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	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
			*Hepatotoxicity
			*[[Pancreatitis]]
			*GI bleed
			*Hypersensitivity reaction
			*[[Anaphylaxis]]
			*[[Toxic epidermal necrolysis]]
			*[[Stevens-Johnson syndrome]]
			*PR prolongation/AV block
			*Hypercholesterolemia/hypertriglyceridemia
			*[[Diabetes mellitus]]/hyperglycemia
			*[[Immune reconstitution syndrome]]
			*Autoimmune disorders
			*[[Hypertension]]
			*[[Syncope]]
			*Orthostatic hypotension
			*Myopathy
			*[[Thrombocytopenia]]

	===Common===		===Common===
			*Nausea/vomiting
			*Diarrhea
			*Paresthesia
			*Fatigue
			*Rash
			*Abdominal pain
			*Cough
			*Dysgeusia
			*Oropharyngeal pain
			*Dizziness
			*AST, ALT, CK elevation
			*Edema
			*Acne
			*Lipodystrophy

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 3-5 hours
	*Metabolism:		*Metabolism: Liver (CYP450)
	*Excretion:		*Excretion: Fecal

	==Mechanism of Action==		==Mechanism of Action==

Rossdonaldson1: Created page with "==Administration== Type: Dosage Forms: Routes of Administration: Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== ===Drug pregnan..."

2020-03-21T11:15:52Z

Created page with "==Administration== *Type: *Dosage Forms: *Routes of Administration: *Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== ===Drug pregnan..."

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==Administration==
*Type:
*Dosage Forms:
*Routes of Administration:
*Common Trade Names:

==Adult Dosing==

==Pediatric Dosing==

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*

===Lactation risk===
*

===Renal Dosing===
*Adult:
*Pediatric:

===Hepatic Dosing===
*Adult:
*Pediatric:

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===

===Common===

==Pharmacology==
*Half-life:
*Metabolism:
*Excretion:

==Mechanism of Action==

==Comments==

==See Also==

==References==
<references/>

[[Category:Pharmacology]]