Ribavirin - Revision history

ClaireLewis: /* References */

2019-09-23T22:17:39Z

References

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	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:ID]]

Mholtz: Text replacement - "OR" to "'''OR'''"

2017-05-30T22:33:14Z

Text replacement - "OR" to "'''OR'''"

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	==Pediatric Dosing==		==Pediatric Dosing==
	*Hep C: >2 years old: 15mg/kg daily OR 400-1200mg daily		*Hep C: >2 years old: 15mg/kg daily '''OR''' 400-1200mg daily
	*RSV (severe cases): 20mg/ml aerosolized over 12-18 hours x 3-7 days		*RSV (severe cases): 20mg/ml aerosolized over 12-18 hours x 3-7 days

ClaireLewis: /* Administration */

2017-02-25T23:09:50Z

Administration

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	==Administration==		==Administration==
	*Type: Antiviral- FDA approved for [[Hepatitis C]], severe [[RSV]] infection. Off-label use: [[herpes simplex]], [[influenza]], [[viral hemorrhagic fever]]		*Type: [[Antiviral]]- FDA approved for [[Hepatitis C]], severe [[RSV]] infection. Off-label use: [[herpes simplex]], [[influenza]], [[viral hemorrhagic fever]]
	*Dosage Forms: 200 tab, 200 cap		*Dosage Forms: 200 tab, 200 cap
	*Routes of Administration: Oral, inhalation		*Routes of Administration: Oral, inhalation

ClaireLewis: Created page with "==Administration== *Type: Antiviral- FDA approved for Hepatitis C, severe RSV infection. Off-label use: herpes simplex, influenza, viral hemorrhagic fever..."

2016-10-05T04:02:39Z

Created page with "==Administration== *Type: Antiviral- FDA approved for Hepatitis C, severe RSV infection. Off-label use: herpes simplex, influenza, viral hemorrhagic fever..."

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==Administration==
*Type: Antiviral- FDA approved for [[Hepatitis C]], severe [[RSV]] infection. Off-label use: [[herpes simplex]], [[influenza]], [[viral hemorrhagic fever]]
*Dosage Forms: 200 tab, 200 cap
*Routes of Administration: Oral, inhalation
*Common Trade Names: Copegus, Rebetol, Ribasphere

==Adult Dosing==
*200-1000mg daily (dose depends on genotype and concurrent treatment with interferon)

==Pediatric Dosing==
*Hep C: >2 years old: 15mg/kg daily OR 400-1200mg daily
*RSV (severe cases): 20mg/ml aerosolized over 12-18 hours x 3-7 days

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: X
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Renal dosing: reduced doses for mild-moderate impairment, do not use if CrCl <50

==Contraindications==
*Allergy to class/drug
*[[Autoimmune hepatitis]]
*Coadministration with didanosine
*Hemoglobinopathy (e.g. [[thalassemia]], [[sickle cell]])
*[[Pregnant]] or potentially pregnant women, men who may impregnate someone
*Renal impairment (CrCl <50)

==Adverse Reactions==
===Serious===
*[[Hemolytic anemia]], [[TTP]]
*[[Bacterial disease]]
*[[Hepatotoxicity]]
*[[MI]]
*[[Suicide]]

===Common===
*[[Neutropenia]]
*[[Nausea]], [[vomiting]], [[diarrhea]]
*Asthenia, [[dizziness]], [[fatigue]]
*Weight loss
*[[Pruritus]]

==Pharmacology==
*Half-life: ~300 hours
*Metabolism:
*Excretion: Mostly renal

==Mechanism of Action==
*Mechanism not well understood

==Comments==

==See Also==
*[[Viral hepatitis]]
*[[Hepatitis C]]

==References==
<references/>
[[Category:Pharmacology]]