Purple glove syndrome - Revision history

Elcatracho: /* Management */

2021-03-08T03:53:32Z

Management

← Revisión anterior		Revisión del 03:53 8 mar 2021
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	*Optimal management remains unclear		*Optimal management remains unclear
	*Some case reports found improvement with		*Some case reports found improvement with
	**topical [[nitroglycerin[[		**topical [[nitroglycerin]]
	**brachial plexus nerve block		**brachial plexus nerve block
	**elevation, heat application, soft tissue massage		**elevation, heat application, soft tissue massage

ClaireLewis: /* Management */

2019-09-28T01:13:06Z

Management

← Revisión anterior		Revisión del 01:13 28 sep 2019
Línea 30:		Línea 30:
	*Optimal management remains unclear		*Optimal management remains unclear
	*Some case reports found improvement with		*Some case reports found improvement with
	**topical nitroglycerin		**topical [[nitroglycerin[[
	**brachial plexus nerve block		**brachial plexus nerve block
	**elevation, heat application, soft tissue massage		**elevation, heat application, soft tissue massage

Mholtz: Text replacement - "* " to "*"

2017-07-24T01:12:48Z

Text replacement - "* " to "*"

← Revisión anterior		Revisión del 01:12 24 jul 2017
Línea 31:		Línea 31:
	*Some case reports found improvement with		*Some case reports found improvement with
	**topical nitroglycerin		**topical nitroglycerin
	** brachial plexus nerve block		**brachial plexus nerve block
	**elevation, heat application, soft tissue massage		**elevation, heat application, soft tissue massage
	*Consider vascular or hand consult if digital or skin necrosis suspected		*Consider vascular or hand consult if digital or skin necrosis suspected

Rossdonaldson1: /* Differential Diagnosis */

2017-06-01T16:30:43Z

Differential Diagnosis

← Revisión anterior		Revisión del 16:30 1 jun 2017
Línea 18:		Línea 18:

	==Differential Diagnosis==		==Differential Diagnosis==
			*Simple IV fluid extravasation
			*[[Arterial thrombosis]]
			*[[Compartment syndrome]]

			{{SSTI DDX}}

	==Evaluation==		==Evaluation==

Mholtz at 01:16, 10 May 2017

2017-05-10T01:16:53Z

← Revisión anterior		Revisión del 01:16 10 may 2017
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	*Uncommon skin complication of [[phenytoin]]		*Uncommon skin complication of [[phenytoin]]
	*Typically associated with IV infiltration of phenytoin, but poorly understood pathophysiology		*Typically associated with IV infiltration of phenytoin, but poorly understood pathophysiology
	**Proposed mechanisms include: <ref>Bhattacharjee P.. Early histopathologic changes in purple glove syndrome. J Cutan Pathol. 2004;31(7):513-5.</ref>		*Proposed mechanisms include:<ref>Bhattacharjee P.. Early histopathologic changes in purple glove syndrome. J Cutan Pathol. 2004;31(7):513-5.</ref>
	***chemical irritation from added propylene glycol and sodium hydroxide		**Chemical irritation from added propylene glycol and sodium hydroxide
	***vasoconstriction		**Vasoconstriction
	***vasculitis		**Vasculitis
	***microthrombus formation		**Microthrombus formation
	*** phenytoin leakage into soft tissue with subsequent edema		**Phenytoin leakage into soft tissue with subsequent edema
	*Generally develops within first 24 hours after infusion, resolves within days to weeks <ref> Santoshi JA. Purple glove syndrome: a case report. Hand surgeons and physicians be aware. J Plast Reconstr Aesthet Surg. 2010;63(3):e340-2.</ref>		*Generally develops within first 24 hours after infusion, resolves within days to weeks <ref> Santoshi JA. Purple glove syndrome: a case report. Hand surgeons and physicians be aware. J Plast Reconstr Aesthet Surg. 2010;63(3):e340-2.</ref>

Línea 18:		Línea 18:

	==Differential Diagnosis==		==Differential Diagnosis==


	==Evaluation==		==Evaluation==
	*Clinical diagnosis based on history and exam		*Clinical diagnosis based on history and exam

	==Management==		==Management==
	*Optimal management remains unclear		*Optimal management remains unclear
Línea 29:		Línea 31:
	*Consider vascular or hand consult if digital or skin necrosis suspected		*Consider vascular or hand consult if digital or skin necrosis suspected
	**Anticoagulation is occasionally started (no clear evidence that it is effective) <ref>Scumpia AJ. Purple glove syndrome after intravenous phenytoin administration presenting in the emergency department. J Emerg Med. 2013;44(2):e281-3.</ref>		**Anticoagulation is occasionally started (no clear evidence that it is effective) <ref>Scumpia AJ. Purple glove syndrome after intravenous phenytoin administration presenting in the emergency department. J Emerg Med. 2013;44(2):e281-3.</ref>

	==Disposition==		==Disposition==
	*Given possibility of severe outcomes, recommend 24 hours of observation in asymptomatic patients		*Given possibility of severe outcomes, recommend 24 hours of observation in asymptomatic patients
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	==External Links==		==External Links==


	==References==		==References==
	<references/>		<references/>

	[[Category:Toxicology]] [[Category:Dermatology]]		[[Category:Toxicology]]
			[[Category:Dermatology]]

Lisayee25 at 00:55, 10 May 2017

2017-05-10T00:55:19Z

← Revisión anterior		Revisión del 00:55 10 may 2017
Línea 11:		Línea 11:

	[[File:Purple_glove_syndrome.png\|thumb\|]]		[[File:Purple_glove_syndrome.png\|thumb\|]]


	==Clinical Features==		==Clinical Features==

Lisayee25 at 00:54, 10 May 2017

2017-05-10T00:54:40Z

← Revisión anterior		Revisión del 00:54 10 may 2017
Línea 9:		Línea 9:
	*** phenytoin leakage into soft tissue with subsequent edema		*** phenytoin leakage into soft tissue with subsequent edema
	*Generally develops within first 24 hours after infusion, resolves within days to weeks <ref> Santoshi JA. Purple glove syndrome: a case report. Hand surgeons and physicians be aware. J Plast Reconstr Aesthet Surg. 2010;63(3):e340-2.</ref>		*Generally develops within first 24 hours after infusion, resolves within days to weeks <ref> Santoshi JA. Purple glove syndrome: a case report. Hand surgeons and physicians be aware. J Plast Reconstr Aesthet Surg. 2010;63(3):e340-2.</ref>

			[[File:Purple_glove_syndrome.png\|thumb\|]]


	==Clinical Features==		==Clinical Features==
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	==References==		==References==
	<references/>		<references/>

			[[Category:Toxicology]] [[Category:Dermatology]]

Lisayee25: Created page with "==Background== Uncommon skin complication of phenytoin Typically associated with IV infiltration of phenytoin, but poorly understood pathophysiology **Proposed mechanism..."

2017-05-10T00:51:46Z

Created page with "==Background== *Uncommon skin complication of phenytoin *Typically associated with IV infiltration of phenytoin, but poorly understood pathophysiology **Proposed mechanism..."

Página nueva

==Background==
*Uncommon skin complication of [[phenytoin]]
*Typically associated with IV infiltration of phenytoin, but poorly understood pathophysiology
**Proposed mechanisms include: <ref>Bhattacharjee P.. Early histopathologic changes in purple glove syndrome. J Cutan Pathol. 2004;31(7):513-5.</ref>
***chemical irritation from added propylene glycol and sodium hydroxide
***vasoconstriction
***vasculitis
***microthrombus formation
*** phenytoin leakage into soft tissue with subsequent edema
*Generally develops within first 24 hours after infusion, resolves within days to weeks <ref> Santoshi JA. Purple glove syndrome: a case report. Hand surgeons and physicians be aware. J Plast Reconstr Aesthet Surg. 2010;63(3):e340-2.</ref>

==Clinical Features==
*Peripheral edema, blistering, pain, and discoloration of the extremity receiving intravenous phenytoin
*Pulses and sensation may be diminished
*Skin necrosis may develop

==Differential Diagnosis==

==Evaluation==
*Clinical diagnosis based on history and exam
==Management==
*Optimal management remains unclear
*Some case reports found improvement with
**topical nitroglycerin
** brachial plexus nerve block
**elevation, heat application, soft tissue massage
*Consider vascular or hand consult if digital or skin necrosis suspected
**Anticoagulation is occasionally started (no clear evidence that it is effective) <ref>Scumpia AJ. Purple glove syndrome after intravenous phenytoin administration presenting in the emergency department. J Emerg Med. 2013;44(2):e281-3.</ref>
==Disposition==
*Given possibility of severe outcomes, recommend 24 hours of observation in asymptomatic patients

==See Also==
*[[Phenytoin toxicity]]
*[[Phenytoin]]
*[[DRESS syndrome]]

==External Links==

==References==
<references/>