Propylthiouracil - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:58:31Z

Switch SMW query from broadtable to table format for better layout with TOC

← Revisión anterior		Revisión del 21:58 20 mar 2026
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	\|?Has Route=Route		\|?Has Route=Route
	\|?Has Population=Population		\|?Has Population=Population
	\|format=~~broadtable~~		\|format=table
	\|headers=plain		\|headers=plain
	\|mainlabel=-		\|mainlabel=-

Danbot: Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

2026-03-20T17:26:13Z

Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

← Revisión anterior		Revisión del 17:26 20 mar 2026
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	\|format=broadtable		\|format=broadtable
	\|headers=plain		\|headers=plain
	\|~~link~~=~~subject~~		\|mainlabel=-
	\|sort=Has Indication		\|sort=Has Indication
	\|limit=50		\|limit=50

Danbot: Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

2026-03-20T16:44:22Z

Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

← Revisión anterior		Revisión del 16:44 20 mar 2026
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	==Comments==		==Comments==


			==Indications by Condition==
			''The following table is automatically generated from disease/condition pages across WikEM.''

			{{#ask:[[Has DrugName::Propylthiouracil]]
			\|?Has Indication=Indication
			\|?Has Dose=Dose
			\|?Has Context=Context
			\|?Has Route=Route
			\|?Has Population=Population
			\|format=broadtable
			\|headers=plain
			\|link=subject
			\|sort=Has Indication
			\|limit=50
			}}

	==See Also==		==See Also==

Rossdonaldson1: /* Serious */

2019-12-10T06:03:42Z

Serious

← Revisión anterior		Revisión del 06:03 10 dic 2019
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	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
			''Both PTU and methimazole can cause agranulocytosis and hepatotoxicity, but to a lesser extent with methimazole''
	*Agranulocytosis, aplastic anemia		*Agranulocytosis, aplastic anemia
	*Hepatotoxicity, liver failure		*Hepatotoxicity, liver failure
	*Nephritis		*Nephritis
	*Vasculitis		*Vasculitis

	~~(Both PTU and methimazole can cause agranulocytosis and hepatotoxicity, but to a lesser extent with methimazole.)~~

	===Common===		===Common===

S18jdavid: /* Serious */

2019-11-18T05:22:12Z

Serious

← Revisión anterior		Revisión del 05:22 18 nov 2019
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	*Nephritis		*Nephritis
	*Vasculitis		*Vasculitis

			(Both PTU and methimazole can cause agranulocytosis and hepatotoxicity, but to a lesser extent with methimazole.)

	===Common===		===Common===
	*Rash		*Rash

ClaireLewis: /* References */

2019-09-23T22:00:58Z

References

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	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:Endocrinology]]

Mholtz: Text replacement - "* " to "*"

2017-07-11T18:44:56Z

Text replacement - "* " to "*"

← Revisión anterior		Revisión del 18:44 11 jul 2017
Línea 13:		Línea 13:

	==Pediatric Dosing==		==Pediatric Dosing==
	* >6yo: 50 mg PO daily, carefully uptitrated		*>6yo: 50 mg PO daily, carefully uptitrated

	==Special Populations==		==Special Populations==

ClaireLewis: Created page with "==Administration== Type: Antithyroid Dosage Forms: Routes of Administration: Other common names: PTU ==Adult Dosing== *Thyroid storm: 500-1000mg PO loading dose, followed..."

2016-11-14T01:12:24Z

Created page with "==Administration== *Type: Antithyroid *Dosage Forms: *Routes of Administration: *Other common names: PTU ==Adult Dosing== *Thyroid storm: 500-1000mg PO loading dose, followed..."

Página nueva

==Administration==
*Type: Antithyroid
*Dosage Forms:
*Routes of Administration:
*Other common names: PTU

==Adult Dosing==
*Thyroid storm: 500-1000mg PO loading dose, followed by 250mg PO q4h
*Hyperthyroidism
**Initial: 50-300mg PO TID (based on severity)
**Maintenance: 50mg PO TID
**1st trimester pregnancy: Use lowest dose needed to keep maternal total T3/T4 slightly above normal range for pregnancy, TSH suppressed, and free T4 at or slightly above upper limit of normal for nonpregnant women. Switch to [[methimazole]] for 2nd-3rd trimester

==Pediatric Dosing==
* >6yo: 50 mg PO daily, carefully uptitrated

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: D - see dosing note above
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Renal dosing: No adjustment
*Hepatic dosing:

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Agranulocytosis, aplastic anemia
*Hepatotoxicity, liver failure
*Nephritis
*Vasculitis
===Common===
*Rash

==Pharmacology==
*Half-life: 0.9-4.3h
*Metabolism: Hepatic
*Excretion: Renal

==Mechanism of Action==
*Inhibits thyroperoxidase, blocking thyroid hormone synthesis in the thyroid. In target tissues, blocks 5'-deiodinase, thereby inhibiting conversion of T4 to active T3

==Comments==

==See Also==
*[[Hyperthyroidism]], [[thyroid storm]]
*[[Methimazole]]

==References==
<references/>
[[Category:Pharmacology]]