Pentamidine - Revision history

Danbot: Remove refs with incorrect PMIDs (verified against PubMed)

2026-03-22T10:24:52Z

Remove refs with incorrect PMIDs (verified against PubMed)

← Revisión anterior		Revisión del 10:24 22 mar 2026
Línea 1:		Línea 1:
	==Administration==		==Administration==
	*Type: Antifungal Agent; Antiprotozoal~~<ref>Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985;7(5):625-634. PMID 3903941</ref>~~		*Type: Antifungal Agent; Antiprotozoal
	*Routes of Administration: IM, IV		*Routes of Administration: IM, IV
	*Common Trade Names: Pentam		*Common Trade Names: Pentam

Danbot: Add peer-reviewed reference

2026-03-22T10:16:52Z

Add peer-reviewed reference

← Revisión anterior		Revisión del 10:16 22 mar 2026
Línea 1:		Línea 1:
	==Administration==		==Administration==
	*Type: Antifungal Agent; Antiprotozoal		*Type: Antifungal Agent; Antiprotozoal<ref>Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985;7(5):625-634. PMID 3903941</ref>
	*Routes of Administration: IM, IV		*Routes of Administration: IM, IV
	*Common Trade Names: Pentam		*Common Trade Names: Pentam

Danbot: Restore original dosing content alongside dynamic SMW tables

2026-03-20T02:37:52Z

Restore original dosing content alongside dynamic SMW tables

← Revisión anterior		Revisión del 02:37 20 mar 2026
Línea 5:		Línea 5:

	==Adult Dosing==		==Adult Dosing==
			*PCP treatment, mod-severe: 4mg/kg IV/IM QD x21 days
			**Not 1st-line agent; may consider decreasing dose to 3mg/kg IV/IM QD if toxicities occur

			*PCP prophylaxis: 300mg NEB q4wk
			**Not 1st-line agent; use injectable product via nebulizer; reconstitute 1 vial with 6 mL sterile water; do not mix with other nebulized meds
			**Off label use


	===Indications by Disease===		===Indications by Disease===
	{{#ask: [[Has DrugName::Pentamidine]] [[Has Population::Adult]]		{{#ask: [[Has DrugName::Pentamidine]] [[Has Population::Adult]]
	\|?Treats disease=Disease		\|?Treats disease=Disease
	\|?Has Dose=Dose		\|?Has Dose=Dose
	\|?Has Context=Context		\|?Has Context=Context
	\|format=table		\|format=table
	\|limit=50		\|limit=50
	\|mainlabel=-		\|mainlabel=-
	\|headers=show		\|headers=show
	\|sort=Treats disease		\|sort=Treats disease
	}}		}}

	==Pediatric Dosing==		==Pediatric Dosing==
			*PCP treatment [for >4 mo]: 4mg/kg IV/IM QD x21 days
			**Not 1st-line agent
			**Consider decreasing dose to 3mg/kg IV/IM QD if toxicities occur
			**Switch to PO regimen to complete course if improvement after 7-10 days

			*PCP prophylaxis [>5 yo]: 300mg NEB q4wk
			**Not 1st-line agent
			**Use injectable product via nebulizer; reconstitute 1 vial with 6 mL sterile water
			**Do not mix with other nebulized meds
			**Off label use


	===Indications by Disease===		===Indications by Disease===
	{{#ask: [[Has DrugName::Pentamidine]] [[Has Population::Pediatric]]		{{#ask: [[Has DrugName::Pentamidine]] [[Has Population::Pediatric]]
	\|?Treats disease=Disease		\|?Treats disease=Disease
	\|?Has Dose=Dose		\|?Has Dose=Dose
	\|?Has Context=Context		\|?Has Context=Context
	\|format=table		\|format=table
	\|limit=50		\|limit=50
	\|mainlabel=-		\|mainlabel=-
	\|headers=show		\|headers=show
	\|sort=Treats disease		\|sort=Treats disease
	}}		}}

Danbot: Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

2026-03-20T01:52:47Z

Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

← Revisión anterior		Revisión del 01:52 20 mar 2026
Línea 5:		Línea 5:

	==Adult Dosing==		==Adult Dosing==
	*PCP treatment, mod-severe: ~~4mg/kg IV/IM QD x21 days~~		===Indications by Disease===
	**Not 1st-line agent; may consider decreasing dose to 3mg/kg IV/IM QD if toxicities occur		{{#ask: [[Has DrugName::Pentamidine]] [[Has Population::Adult]]
			\|?Treats disease=Disease
	*PCP prophylaxis: 300mg NEB q4wk		\|?Has Dose=Dose
	**Not 1st-~~line agent; use injectable product via nebulizer; reconstitute 1 vial with 6 mL sterile water; do not mix with other nebulized meds~~		\|?Has Context=Context
	**Off label use		\|format=table
			\|limit=50
			\|mainlabel=-
			\|headers=show
			\|sort=Treats disease
			}}

	==Pediatric Dosing==		==Pediatric Dosing==
	*PCP treatment [~~for >4 mo~~]: ~~4mg/kg IV/IM QD x21 days~~		===Indications by Disease===
	**Not 1st-line agent		{{#ask: [[Has DrugName::Pentamidine]] [[Has Population::Pediatric]]
	**Consider decreasing dose to 3mg/kg IV/IM QD if toxicities occur		\|?Treats disease=Disease
	**Switch to PO regimen to complete course if improvement after 7-10 days		\|?Has Dose=Dose
			\|?Has Context=Context
	*PCP prophylaxis [>5 yo]: 300mg NEB q4wk		\|format=table
	**Not 1st-~~line agent~~		\|limit=50
	**Use injectable product via nebulizer; reconstitute 1 vial with 6 mL sterile water		\|mainlabel=-
	**Do not mix with other nebulized meds		\|headers=show
	**Off label use		\|sort=Treats disease
			}}

	==Special Populations==		==Special Populations==

ClaireLewis: /* References */

2019-09-23T21:29:24Z

References

← Revisión anterior		Revisión del 21:29 23 sep 2019
Línea 69:		Línea 69:
	<Epocrates, UpToDate>		<Epocrates, UpToDate>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:ID]]

Mholtz: Text replacement - "qd" to "QD"

2017-07-07T08:13:29Z

Text replacement - "qd" to "QD"

← Revisión anterior		Revisión del 08:13 7 jul 2017
Línea 5:		Línea 5:

	==Adult Dosing==		==Adult Dosing==
	*PCP treatment, mod-severe: 4mg/kg IV/IM qd x21 days		*PCP treatment, mod-severe: 4mg/kg IV/IM QD x21 days
	**Not 1st-line agent; may consider decreasing dose to 3mg/kg IV/IM qd if toxicities occur		**Not 1st-line agent; may consider decreasing dose to 3mg/kg IV/IM QD if toxicities occur

	*PCP prophylaxis: 300mg NEB q4wk		*PCP prophylaxis: 300mg NEB q4wk
Línea 13:		Línea 13:

	==Pediatric Dosing==		==Pediatric Dosing==
	*PCP treatment [for >4 mo]: 4mg/kg IV/IM qd x21 days		*PCP treatment [for >4 mo]: 4mg/kg IV/IM QD x21 days
	**Not 1st-line agent		**Not 1st-line agent
	**Consider decreasing dose to 3mg/kg IV/IM qd if toxicities occur		**Consider decreasing dose to 3mg/kg IV/IM QD if toxicities occur
	**Switch to PO regimen to complete course if improvement after 7-10 days		**Switch to PO regimen to complete course if improvement after 7-10 days

Neil.m.young: Text replacement - "Cr " to "creatinine "

2016-08-11T06:02:18Z

Text replacement - "Cr " to "creatinine "

← Revisión anterior		Revisión del 06:02 11 ago 2016
Línea 49:		Línea 49:
	===Common===		===Common===
	*renal dysfunction		*renal dysfunction
	*BUN, Cr elevated		*BUN, creatinine elevated
	*injection site necrosis		*injection site necrosis
	*leukopenia		*leukopenia

Neil.m.young: Text replacement - "4 mg" to "4mg"

2016-07-21T13:14:24Z

Text replacement - "4 mg" to "4mg"

← Revisión anterior		Revisión del 13:14 21 jul 2016
Línea 5:		Línea 5:

	==Adult Dosing==		==Adult Dosing==
	*PCP treatment, mod-severe: ~~4 mg~~/kg IV/IM qd x21 days		*PCP treatment, mod-severe: 4mg/kg IV/IM qd x21 days
	**Not 1st-line agent; may consider decreasing dose to 3mg/kg IV/IM qd if toxicities occur		**Not 1st-line agent; may consider decreasing dose to 3mg/kg IV/IM qd if toxicities occur

Línea 13:		Línea 13:

	==Pediatric Dosing==		==Pediatric Dosing==
	*PCP treatment [for >4 mo]: ~~4 mg~~/kg IV/IM qd x21 days		*PCP treatment [for >4 mo]: 4mg/kg IV/IM qd x21 days
	**Not 1st-line agent		**Not 1st-line agent
	**Consider decreasing dose to 3mg/kg IV/IM qd if toxicities occur		**Consider decreasing dose to 3mg/kg IV/IM qd if toxicities occur

Neil.m.young: Text replacement - "0 mg" to "0mg"

2016-07-21T07:01:43Z

Text replacement - "0 mg" to "0mg"

← Revisión anterior		Revisión del 07:01 21 jul 2016
Línea 8:		Línea 8:
	**Not 1st-line agent; may consider decreasing dose to 3mg/kg IV/IM qd if toxicities occur		**Not 1st-line agent; may consider decreasing dose to 3mg/kg IV/IM qd if toxicities occur

	*PCP prophylaxis: ~~300 mg~~ NEB q4wk		*PCP prophylaxis: 300mg NEB q4wk
	**Not 1st-line agent; use injectable product via nebulizer; reconstitute 1 vial with 6 mL sterile water; do not mix with other nebulized meds		**Not 1st-line agent; use injectable product via nebulizer; reconstitute 1 vial with 6 mL sterile water; do not mix with other nebulized meds
	**Off label use		**Off label use
Línea 18:		Línea 18:
	**Switch to PO regimen to complete course if improvement after 7-10 days		**Switch to PO regimen to complete course if improvement after 7-10 days

	*PCP prophylaxis [>5 yo]: ~~300 mg~~ NEB q4wk		*PCP prophylaxis [>5 yo]: 300mg NEB q4wk
	**Not 1st-line agent		**Not 1st-line agent
	**Use injectable product via nebulizer; reconstitute 1 vial with 6 mL sterile water		**Use injectable product via nebulizer; reconstitute 1 vial with 6 mL sterile water
Línea 28:		Línea 28:
	===Renal Dosing===		===Renal Dosing===
	*CrCl <10: give q24-36h		*CrCl <10: give q24-36h
	*HD: give ~~750 mg~~ supplement		*HD: give 750mg supplement
	*PD: no supplement		*PD: no supplement
	===Hepatic Dosing===		===Hepatic Dosing===

Neil.m.young: Text replacement - "3 mg" to "3mg"

2016-07-19T22:22:42Z

Text replacement - "3 mg" to "3mg"

← Revisión anterior		Revisión del 22:22 19 jul 2016
Línea 6:		Línea 6:
	==Adult Dosing==		==Adult Dosing==
	*PCP treatment, mod-severe: 4 mg/kg IV/IM qd x21 days		*PCP treatment, mod-severe: 4 mg/kg IV/IM qd x21 days
	**Not 1st-line agent; may consider decreasing dose to ~~3 mg~~/kg IV/IM qd if toxicities occur		**Not 1st-line agent; may consider decreasing dose to 3mg/kg IV/IM qd if toxicities occur

	*PCP prophylaxis: 300 mg NEB q4wk		*PCP prophylaxis: 300 mg NEB q4wk
Línea 15:		Línea 15:
	*PCP treatment [for >4 mo]: 4 mg/kg IV/IM qd x21 days		*PCP treatment [for >4 mo]: 4 mg/kg IV/IM qd x21 days
	**Not 1st-line agent		**Not 1st-line agent
	**Consider decreasing dose to ~~3 mg~~/kg IV/IM qd if toxicities occur		**Consider decreasing dose to 3mg/kg IV/IM qd if toxicities occur
	**Switch to PO regimen to complete course if improvement after 7-10 days		**Switch to PO regimen to complete course if improvement after 7-10 days