Octreotide - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:57:37Z

Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T17:26:43Z

Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

2026-03-20T16:45:01Z

Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

@@ Línea 57: / Línea 57: @@
 *Although used in the ED mainly for sulfonylurea overdose and variceal bleeding, it is used in outpatient and inpatient medicine for the treatment of acromegaly, carcinoid tumors, and VIPomas
 *Octreotide was originally used as a opioid antagonist and is still used off label as a second/third line therapy for diarrhea from opioid withdrawal because of antidiarrheal properties.<ref>Carreno JE et al. 24-hour opiate detoxification and antagonist induction at home– the ‘asturian method’: A report on 1368 procedures. Addict Biol. 2002;7(2):243-250.</ref>
 ==See Also==

2023-10-18T17:48:11Z

Text replacement - "opiod" to "opioid"

← Revisión anterior		Revisión del 17:48 18 oct 2023
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	==Comments==		==Comments==
	*Although used in the ED mainly for sulfonylurea overdose and variceal bleeding, it is used in outpatient and inpatient medicine for the treatment of acromegaly, carcinoid tumors, and VIPomas		*Although used in the ED mainly for sulfonylurea overdose and variceal bleeding, it is used in outpatient and inpatient medicine for the treatment of acromegaly, carcinoid tumors, and VIPomas
	*Octreotide was originally used as a ~~opiod~~ antagonist and is still used off label as a second/third line therapy for diarrhea from ~~opiod~~ withdrawal because of antidiarrheal properties.<ref>Carreno JE et al. 24-hour opiate detoxification and antagonist induction at home– the ‘asturian method’: A report on 1368 procedures. Addict Biol. 2002;7(2):243-250.</ref>		*Octreotide was originally used as a opioid antagonist and is still used off label as a second/third line therapy for diarrhea from opioid withdrawal because of antidiarrheal properties.<ref>Carreno JE et al. 24-hour opiate detoxification and antagonist induction at home– the ‘asturian method’: A report on 1368 procedures. Addict Biol. 2002;7(2):243-250.</ref>

	==See Also==		==See Also==

2021-02-10T15:09:20Z

Comments

← Revisión anterior		Revisión del 15:09 10 feb 2021
Línea 55:		Línea 55:

	==Comments==		==Comments==
	*Although used in the ED mainly for sulfonylurea overdose and ~~vatical~~ bleeding, it is used in outpatient and inpatient medicine for the treatment of acromegaly, carcinoid tumors, and VIPomas		*Although used in the ED mainly for sulfonylurea overdose and variceal bleeding, it is used in outpatient and inpatient medicine for the treatment of acromegaly, carcinoid tumors, and VIPomas
	*Octreotide was originally used as a opiod antagonist and is still used off label as a second/third line therapy for diarrhea from opiod withdrawal because of antidiarrheal properties.<ref>Carreno JE et al. 24-hour opiate detoxification and antagonist induction at home– the ‘asturian method’: A report on 1368 procedures. Addict Biol. 2002;7(2):243-250.</ref>		*Octreotide was originally used as a opiod antagonist and is still used off label as a second/third line therapy for diarrhea from opiod withdrawal because of antidiarrheal properties.<ref>Carreno JE et al. 24-hour opiate detoxification and antagonist induction at home– the ‘asturian method’: A report on 1368 procedures. Addict Biol. 2002;7(2):243-250.</ref>

2019-01-26T18:54:09Z

Special Populations

← Revisión anterior		Revisión del 18:54 26 ene 2019
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	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]:		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: Octreotide crosses the placenta and can be detected in newborn at birth. Limited data on risk, case studies have not demonstrated any congenital malformations in fetuses.
	*[[Lactation risk categories\|Lactation risk]]:		*[[Lactation risk categories\|Lactation risk]]:
	===Renal Dosing===		===Renal Dosing===
	~~No renal dosing adjustments~~		*Dialysis patients: dosage adjustment may be required as clearance is reduced by ~50%.

	===Hepatic Dosing===		===Hepatic Dosing===
	No ~~hepatic dosing~~ adjustments but ~~half life~~ is ~~increased~~ in patients with cirrhosis		No adjustments needed but clearance is reduced in patients with cirrhosis.

	==Contraindications==		==Contraindications==

2017-10-31T09:56:36Z

Adverse Reactions

← Revisión anterior		Revisión del 09:56 31 oct 2017
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	*[[Hypoglycemia]] is rare but more common in older adults and type I diabetics<ref>Howland MA, Smith SW. Antidotes in depth. In: Robert S. Hoffman, et al., ed. Goldfrank’s toxicologic emergencies. 10e ed. ; 2015.</ref>		*[[Hypoglycemia]] is rare but more common in older adults and type I diabetics<ref>Howland MA, Smith SW. Antidotes in depth. In: Robert S. Hoffman, et al., ed. Goldfrank’s toxicologic emergencies. 10e ed. ; 2015.</ref>

	~~<big>~~Serious~~</big>~~		====Serious====
	* pancreatitis		* pancreatitis
	* bradycardia		* bradycardia
Línea 39:		Línea 39:
	* thrombocytopenia		* thrombocytopenia

	~~<big>~~Common~~</big>~~		====Common====
	* nausea/vomiting/diarrhea		* nausea/vomiting/diarrhea
	* dizziness		* dizziness

2017-10-13T15:53:55Z

Adverse Reactions

@@ Línea 31: / Línea 31: @@
 ==Adverse Reactions==
 *[[Hypoglycemia]] is rare but more common in older adults and type I diabetics<ref>Howland MA, Smith SW. Antidotes in depth. In: Robert S. Hoffman, et al., ed. Goldfrank’s toxicologic emergencies. 10e ed. ; 2015.</ref>
 ==Pharmacology==

2016-09-24T17:37:18Z

Variceal Bleeding

← Revisión anterior		Revisión del 17:37 24 sep 2016
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	==Adult Dosing==		==Adult Dosing==
	===Variceal ~~Bleeding~~===		===[[Variceal bleeding]]===
	*Initial Bolus: 50mcg IV (range 25-100mcg)<ref>Garbuzenko DV. Current approaches to the management of patients with liver cirrhosis who have acute esophageal variceal bleeding. Curr Med Res Opin. 2016:1-9.</ref>		*Initial Bolus: 50mcg IV (range 25-100mcg)<ref>Garbuzenko DV. Current approaches to the management of patients with liver cirrhosis who have acute esophageal variceal bleeding. Curr Med Res Opin. 2016:1-9.</ref>
	*Drip rate: 25-50 mcg/hr IV		*Drip rate: 25-50 mcg/hr IV

2016-09-24T17:36:49Z

Sulfonylurea Overdose

← Revisión anterior		Revisión del 17:36 24 sep 2016
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	*Drip rate: 25-50 mcg/hr IV		*Drip rate: 25-50 mcg/hr IV

	===Sulfonylurea ~~Overdose~~===		===[[Sulfonylurea toxicity]]===
	*50-75 mpg SQ or IM every 6 hrs as needed		*50-75 mpg SQ or IM every 6 hrs as needed