N-Acetylcysteine - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:55:35Z

Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T17:25:34Z

Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

2026-03-20T16:43:43Z

Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

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 *Mechanism of Action:
 **Intravenous acetylcysteine is indicated for the treatment of acetaminophen overdose by preventing depletion of glutathione reserves.
 ==See Also==

2020-12-21T19:09:52Z

General

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	Acetylcysteine, or ''N''-acetylcysteine (NAC), is a medication that is used to treat acetaminophen overdose. It can also be used as a nebulized medication to help loosen thick pulmonary sections.		Acetylcysteine, or ''N''-acetylcysteine (NAC), is a medication that is used to treat acetaminophen overdose. It can also be used as a nebulized medication to help loosen thick pulmonary sections.

	NAC ~~prevents toxicity by limiting~~ the ~~formation of NAPQI~~ which ~~increases~~ the ~~ability to detoxify~~ the NAPQI ~~that is formed via hepatotoxic substances such as acetaminophen~~.		When acetaminophen is taken in large doses, a toxic metabolite N-acetyl-pbenzoquinone imine (NAPQI) accumulates in the body. NAC helps to replete glutathione reserves in the liver, which helps the liver prevent damage from the hepatotoxic NAPQI metabolite.

	*Type: Antioxidant, [[antidote]]		*Type: Antioxidant, [[antidote]]
	*Dosage Forms:, IV, PO		*Dosage Forms:, IV, PO, Nebulized
	*Common Trade Names: NAC;		*Common Trade Names: NAC;

2020-12-21T18:59:06Z

General

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	==General==		==General==
	N-acetylcysteine (NAC) prevents toxicity by limiting the formation of NAPQI which increases the ability to detoxify the NAPQI that is formed via hepatotoxic substances such as ~~tylenol~~.
			Acetylcysteine, or ''N''-acetylcysteine (NAC), is a medication that is used to treat acetaminophen overdose. It can also be used as a nebulized medication to help loosen thick pulmonary sections.

			NAC prevents toxicity by limiting the formation of NAPQI which increases the ability to detoxify the NAPQI that is formed via hepatotoxic substances such as acetaminophen.

	*Type: Antioxidant, [[antidote]]		*Type: Antioxidant, [[antidote]]

2020-01-23T04:12:35Z

Adverse Reactions

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	===Serious===		===Serious===
	*Anaphylactoid reaction but also associated with seizures, cerebral edema, & herniation. <ref>http://journals.lww.com/em-news/Fulltext/2012/02000/Toxicology_Rounds__Lessons_from_the_Courtroom_.9.aspx</ref>		*Anaphylactoid reaction but also associated with seizures, cerebral edema, & herniation. <ref>http://journals.lww.com/em-news/Fulltext/2012/02000/Toxicology_Rounds__Lessons_from_the_Courtroom_.9.aspx</ref>
	*[[Anaphylaxis]] responds to standard therapies and can usually restart NAC ~~without~~ safely without complications. <ref>Sandilands EA, Bateman DN. Adverse reactions associated with acetylcysteine. Clin Toxicol (Phila). 2009;47(2):81-88. (Systematic literature review)</ref>		*[[Anaphylaxis]] responds to standard therapies and can usually restart NAC safely without complications. <ref>Sandilands EA, Bateman DN. Adverse reactions associated with acetylcysteine. Clin Toxicol (Phila). 2009;47(2):81-88. (Systematic literature review)</ref>
	**No treatment is necessary for isolated flushing		**No treatment is necessary for isolated flushing
	**If urticaria, then [[Diphenhydramine]]		**If urticaria, then [[Diphenhydramine]]

2019-09-22T23:45:09Z

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	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]:		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: B
	{{NAC use in pregnancy}}		{{NAC use in pregnancy}}

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	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:Toxicology]]

2019-09-22T23:44:23Z

General

← Revisión anterior		Revisión del 23:44 22 sep 2019
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	N-acetylcysteine (NAC) prevents toxicity by limiting the formation of NAPQI which increases the ability to detoxify the NAPQI that is formed via hepatotoxic substances such as tylenol.		N-acetylcysteine (NAC) prevents toxicity by limiting the formation of NAPQI which increases the ability to detoxify the NAPQI that is formed via hepatotoxic substances such as tylenol.

	*Type: Antioxidant		*Type: Antioxidant, [[antidote]]
	*Dosage Forms:, IV, PO		*Dosage Forms:, IV, PO
	*Common Trade Names: NAC;		*Common Trade Names: NAC;

2019-05-02T04:09:24Z

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	*sulfur-smell causes nausea and vomiting. Consider mixing with juice or soda, in a cup with a lid and straw		*sulfur-smell causes nausea and vomiting. Consider mixing with juice or soda, in a cup with a lid and straw

	==Pharmacology==		==Pharmacology<ref>Acetylcysteine: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.</ref>==
	*Half-life:		*Half-life:
	** Reduced acetylcysteine: 2 hours		** Reduced acetylcysteine: 2 hours
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	==References==		==References==
	<references/>		<references/>
	* Acetylcysteine: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.
	[[Category:Pharmacology]]		[[Category:Pharmacology]]

2019-04-02T18:52:21Z

References: added

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	==References==		==References==
	<references/>		<references/>
			* Acetylcysteine: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.
	[[Category:Pharmacology]]		[[Category:Pharmacology]]