Methylprednisolone - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:55:39Z

Switch SMW query from broadtable to table format for better layout with TOC

← Revisión anterior		Revisión del 21:55 20 mar 2026
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	\|?Has Route=Route		\|?Has Route=Route
	\|?Has Population=Population		\|?Has Population=Population
	\|format=~~broadtable~~		\|format=table
	\|headers=plain		\|headers=plain
	\|mainlabel=-		\|mainlabel=-

Danbot: Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

2026-03-20T17:24:41Z

Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

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	\|format=broadtable		\|format=broadtable
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	\|sort=Has Indication		\|sort=Has Indication
	\|limit=50		\|limit=50

Danbot: Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

2026-03-20T16:42:49Z

Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

@@ Línea 38: / Línea 38: @@
 *Excretion: Urine excretion
 *Mechanism of Action: Potent anti-inflammatory properties with minimal mineralocorticoid activity
 ==See Also==

Blsimpso: /* Pharmacology */

2022-10-03T13:14:00Z

Pharmacology

← Revisión anterior		Revisión del 13:14 3 oct 2022
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	==Pharmacology==		==Pharmacology==
	*Half-life: 0.25 hours (IV)		*Half-life: 0.25 hours (IV)<ref>Ocejo A, Correa R. Methylprednisolone. [Updated 2022 May 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK544340/</ref>
	*Metabolism: Hepatic		*Metabolism: Hepatic
	*Excretion: Urine excretion		*Excretion: Urine excretion

Blsimpso: /* Pharmacology */

2022-10-03T13:13:17Z

Pharmacology

← Revisión anterior		Revisión del 13:13 3 oct 2022
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	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 0.25 hours (IV)
	*Metabolism:		*Metabolism: Hepatic
	*Excretion:		*Excretion: Urine excretion
	*Mechanism of Action:		*Mechanism of Action: Potent anti-inflammatory properties with minimal mineralocorticoid activity

	==See Also==		==See Also==

Neil.m.young: Text replacement - "5 mg" to "5mg"

2016-07-20T12:56:59Z

Text replacement - "5 mg" to "5mg"

← Revisión anterior		Revisión del 12:56 20 jul 2016
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	==Adult Dosing==		==Adult Dosing==
	===[[Anaphylaxis]]===		===[[Anaphylaxis]]===
	*~~125 mg~~ IV		*125mg IV

	==Pediatric Dosing==		==Pediatric Dosing==

Ostermayer: Text replacement - "Category:Drugs" to "Category:Pharmacology"

2016-03-22T15:53:29Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"

← Revisión anterior		Revisión del 15:53 22 mar 2016
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	==References==		==References==
	<references/>		<references/>
	[[Category:~~Drugs~~]]		[[Category:Pharmacology]]

Rossdonaldson1: /* Sources */

2015-10-01T01:18:29Z

Sources

← Revisión anterior		Revisión del 01:18 1 oct 2015
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	==See Also==		==See Also==

	==~~Sources~~==		==References==

	<references/>		<references/>
	[[Category:Drugs]]		[[Category:Drugs]]

Catierey: added spinal cord injury note

2015-09-29T16:35:53Z

added spinal cord injury note

← Revisión anterior		Revisión del 16:35 29 sep 2015
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	*Type: [[Corticosteroid]]		*Type: [[Corticosteroid]]
	*Dosage Forms: IM; IV		*Dosage Forms: IM; IV
	*Common Trade Names:		*Common Trade Names: Medrol, Solu-Medrol

	==Adult Dosing==		==Adult Dosing==
Línea 13:		Línea 13:

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]:		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C(US)
	*Lactation:		*Lactation: Oral maternal doses to 8mg daily is safe. Recommend waiting 2-8 hours after infusion of 1 gm. <ref>[http://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~w439Lx:1 Lactmed: Methylprednisolone] </ref>
	*Renal Dosing		*Renal Dosing
	**Adult		**Adult: not available
	**Pediatric		**Pediatric: not available
	*Hepatic Dosing		*Hepatic Dosing
	**Adult		**Adult: not available
	**Pediatric		**Pediatric: not available

			===[[EBQ:High Dose Steroids in Cord Injury#Major Points\|Controversial Use in Spinal Cord Injury]]===
			*Steroid use for spinal cord injury was a controversial treatment during the 1990s and 2000s, with the NASCIS II and III studies reporting positive outcomes in a subgroup analysis of patients who received methylpredisolone within 8 hours of injury. Multiple cochrane reviews performed by the author of the NASCIS trials concluded neurological improvement after injury, but a review of all individual studies demonstrate negative outcomes for both the retrospective and the prospective trials<ref>Steroids for Spinal Cord Injury http://www.trauma.org/archive/spine/steroids.html#NASCIS_1.2C_USA_1984</ref>. Most recent guidelines from the Congress of Neurological Surgeons and American Association of Neurological Surgeons discourage against the use of steroids in spinal cord injury, citing harmful side effects including death.<ref>Anderson P. New CNS/AANS Guidelines Discourage Steroids in Spinal Injury. Medscape Medical News. Mar 28 2013</ref>

	==Contraindications==		==Contraindications==

Rossdonaldson1: /* General */

2015-03-10T23:41:38Z

General

← Revisión anterior		Revisión del 23:41 10 mar 2015
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	==General==		==General==
	*Type: [[~~Corticosteriod~~]]		*Type: [[Corticosteroid]]
	*Dosage Forms:		*Dosage Forms: IM; IV
	*Common Trade Names:		*Common Trade Names:

	==Adult Dosing==		==Adult Dosing==