Methotrexate - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:57:02Z

Switch SMW query from broadtable to table format for better layout with TOC

← Revisión anterior		Revisión del 21:57 20 mar 2026
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	\|?Has Route=Route		\|?Has Route=Route
	\|?Has Population=Population		\|?Has Population=Population
	\|format=~~broadtable~~		\|format=table
	\|headers=plain		\|headers=plain
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Danbot: Add SMW Indications by Condition query table

2026-03-20T18:20:22Z

Add SMW Indications by Condition query table

@@ Línea 52: / Línea 52: @@
 *Inhibits dihydrofolate reductase→ blocks DNA synthesis and thus, cellular replication/repair
 ==Comments==
 ==See Also==

Elcatracho: /* Administration */

2021-03-08T19:44:37Z

Administration

← Revisión anterior		Revisión del 19:44 8 mar 2021
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	*Dosage Forms:		*Dosage Forms:
	*Routes of Administration: IV/IM, oral		*Routes of Administration: IV/IM, oral
	*Common Trade Names:		*Common Trade Names: Trexall, Rheumatrex, Otrexup

	==Adult Dosing==		==Adult Dosing==

Alvarez13: /* See Also */

2018-02-22T15:16:30Z

Mholtz: Text replacement - "-->" to "→"

2017-02-08T23:16:58Z

Text replacement - "-->" to "→"

← Revisión anterior		Revisión del 23:16 8 feb 2017
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	==Mechanism of Action==		==Mechanism of Action==
	*Inhibits dihydrofolate ~~reductase-->~~ blocks DNA synthesis and thus, cellular replication/repair		*Inhibits dihydrofolate reductase→ blocks DNA synthesis and thus, cellular replication/repair
	==Comments==		==Comments==

Rossdonaldson1: /* Adverse Reactions */

2016-10-03T21:03:28Z

Adverse Reactions

← Revisión anterior		Revisión del 21:03 3 oct 2016
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	*Hepatotoxicity		*Hepatotoxicity
	*Nephrotoxicity		*Nephrotoxicity
	*Myelosuppression, aplastic anemia, pancytopenia		*Myelosuppression, [[aplastic anemia]], [[pancytopenia]]
	*Infectious disease		*Infectious disease
	*Tumor lysis syndrome		*[[Tumor lysis syndrome]]
	*GI bleed		*[[GI bleed]]
	*Neurotoxicity, seizure		*Neurotoxicity, [[seizure]]
	*Pericardial effusion		*[[Pericardial effusion]]
	*TEN		*[[TEN]]
	===Common===		===Common===
	*Nausea/vomiting, diarrhea		*[[Nausea/vomiting]], [[diarrhea]]
	*Stomatitis		*Stomatitis
	*Leukopenia, thrombocytopenia		*[[Leukopenia]], [[thrombocytopenia]]
	*Alopecia, photosensitivity, rash		*Alopecia, photosensitivity, [[rash]]
	*Dizziness		*[[Dizziness]]

	==Pharmacology==		==Pharmacology==
	*Half-life: 8-15hr		*Half-life: 8-15hr

Rossdonaldson1: /* Adult Dosing */

2016-10-03T21:01:46Z

Adult Dosing

← Revisión anterior		Revisión del 21:01 3 oct 2016
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	==Adult Dosing==		==Adult Dosing==
	*Ectopic pregnancy: Single-dose regimen: Methotrexate 50 mg/m2		===[[Ectopic pregnancy]]===
			*Single-dose regimen: Methotrexate 50 mg/m2

	==Pediatric Dosing==		==Pediatric Dosing==

Mradigan: Fixed dose

2016-10-03T17:54:21Z

Fixed dose

← Revisión anterior		Revisión del 17:54 3 oct 2016
Línea 6:		Línea 6:

	==Adult Dosing==		==Adult Dosing==
	*Ectopic pregnancy:		*Ectopic pregnancy: Single-dose regimen: Methotrexate 50 mg/m2
	Single-dose regimen: Methotrexate 50 mg/m2 ~~on day 1; Measure serum hCG levels on days 4 and 7; if needed, repeat dose on day 7 (Barnhart 2009)~~
	Two-dose regimen: Methotrexate 50 mg/m2 on day 1; Measure serum hCG levels on day 4 and administer a second dose of methotrexate 50 mg/m2; Measure serum hCG levels on day 7 and if needed, administer a third dose of 50 mg/m2 (Barnhart 2009)

	*Doses for treatment of malignancy or autoimmune diseases vary widely

	==Pediatric Dosing==		==Pediatric Dosing==

Mradigan: /* Adult Dosing */

2016-10-03T17:53:14Z

Adult Dosing

← Revisión anterior		Revisión del 17:53 3 oct 2016
Línea 6:		Línea 6:

	==Adult Dosing==		==Adult Dosing==
	*Ectopic pregnancy: ~~50mg IM once~~		*Ectopic pregnancy:
			Single-dose regimen: Methotrexate 50 mg/m2 on day 1; Measure serum hCG levels on days 4 and 7; if needed, repeat dose on day 7 (Barnhart 2009)
			Two-dose regimen: Methotrexate 50 mg/m2 on day 1; Measure serum hCG levels on day 4 and administer a second dose of methotrexate 50 mg/m2; Measure serum hCG levels on day 7 and if needed, administer a third dose of 50 mg/m2 (Barnhart 2009)

	*Doses for treatment of malignancy or autoimmune diseases vary widely		*Doses for treatment of malignancy or autoimmune diseases vary widely

	==Pediatric Dosing==		==Pediatric Dosing==

ClaireLewis: Created page with "==Administration== Type: Immunosuppressant/antineoplastic Dosage Forms: Routes of Administration: IV/IM, oral Common Trade Names: ==Adult Dosing== *Ectopic pregnancy: 5..."

2016-07-15T00:17:55Z

Created page with "==Administration== *Type: Immunosuppressant/antineoplastic *Dosage Forms: *Routes of Administration: IV/IM, oral *Common Trade Names: ==Adult Dosing== *Ectopic pregnancy: 5..."

Página nueva

==Administration==
*Type: Immunosuppressant/antineoplastic
*Dosage Forms:
*Routes of Administration: IV/IM, oral
*Common Trade Names:

==Adult Dosing==
*Ectopic pregnancy: 50mg IM once
*Doses for treatment of malignancy or autoimmune diseases vary widely
==Pediatric Dosing==

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: X
*[[Lactation risk categories|Lactation risk]]: Infant risk has been determined (risk of serious adverse effects for infant)
===Renal Dosing===
*Adult:
*Pediatric:
===Hepatic Dosing===
*Adult:
*Pediatric:

==Contraindications==
*Allergy to class/drug
*Breastfeeding, pregnant, or possibility of impregnating someone
*Blood dyscrasias
*Chronic liver disease
==Adverse Reactions==
===Serious===
*Hepatotoxicity
*Nephrotoxicity
*Myelosuppression, aplastic anemia, pancytopenia
*Infectious disease
*Tumor lysis syndrome
*GI bleed
*Neurotoxicity, seizure
*Pericardial effusion
*TEN
===Common===
*Nausea/vomiting, diarrhea
*Stomatitis
*Leukopenia, thrombocytopenia
*Alopecia, photosensitivity, rash
*Dizziness
==Pharmacology==
*Half-life: 8-15hr
*Metabolism: Extensive hepatic and intracellular
*Excretion: Mostly renal. Dialyzable.

==Mechanism of Action==
*Inhibits dihydrofolate reductase--> blocks DNA synthesis and thus, cellular replication/repair
==Comments==

==See Also==

==References==
<references/>
[[Category:Pharmacology]]

← Revisión anterior		Revisión del 15:16 22 feb 2018
Línea 54:		Línea 54:

	==See Also==		==See Also==
			[[Methotrexate_toxicity]]

	==References==		==References==
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Methotrexate - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

Danbot: Add SMW Indications by Condition query table

Elcatracho: /* Administration */

Alvarez13: /* See Also */

Mholtz: Text replacement - "-->" to "→"

Rossdonaldson1: /* Adverse Reactions */

Rossdonaldson1: /* Adult Dosing */

Mradigan: Fixed dose

Mradigan: /* Adult Dosing */

ClaireLewis: Created page with "==Administration== *Type: Immunosuppressant/antineoplastic *Dosage Forms: *Routes of Administration: IV/IM, oral *Common Trade Names: ==Adult Dosing== *Ectopic pregnancy: 5..."

ClaireLewis: Created page with "==Administration== Type: Immunosuppressant/antineoplastic Dosage Forms: Routes of Administration: IV/IM, oral Common Trade Names: ==Adult Dosing== *Ectopic pregnancy: 5..."