Methanol toxicity - Revision history

Danbot: Move calculators to own section with header (visible in TOC), expanded, before External Links

2026-03-21T15:06:06Z

Move calculators to own section with header (visible in TOC), expanded, before External Links

← Revisión anterior		Revisión del 15:06 21 mar 2026
Línea 112:		Línea 112:
	*{{MedicationDose\|drug=Sodium bicarbonate\|dose=1-2 mEq/kg IV bolus\|route=IV\|context=Correction of metabolic acidosis\|indication=Methanol toxicity\|population=Adult\|notes=Target pH 7.45-7.50; follow with infusion 150 mEq/L in D5W}}		*{{MedicationDose\|drug=Sodium bicarbonate\|dose=1-2 mEq/kg IV bolus\|route=IV\|context=Correction of metabolic acidosis\|indication=Methanol toxicity\|population=Adult\|notes=Target pH 7.45-7.50; follow with infusion 150 mEq/L in D5W}}
	*{{MedicationDose\|drug=Leucovorin\|dose=50 mg q4hr\|route=IV\|context=Enhanced formic acid metabolism\|indication=Methanol toxicity\|population=Adult\|notes=Facilitates breakdown of formic acid to CO2 and water}}		*{{MedicationDose\|drug=Leucovorin\|dose=50 mg q4hr\|route=IV\|context=Enhanced formic acid metabolism\|indication=Methanol toxicity\|population=Adult\|notes=Facilitates breakdown of formic acid to CO2 and water}}

			== Calculators ==
			{{Osmolal_Gap_Calculator}}

	==See Also==		==See Also==
Línea 120:		Línea 123:
	==References==		==References==
	<references/>		<references/>

	~~<div class="mw-collapsible mw-collapsed" style="border:1px solid #aaa; padding:5px; margin-top:10px;">~~
	~~<div style="font-weight:bold;">📊 Osmolal Gap Calculator [show]</div>~~
	~~<div class="mw-collapsible-content">~~
	~~{{Osmolal_Gap_Calculator}}~~
	~~</div>~~
	~~</div>~~
	[[Category:Toxicology]]		[[Category:Toxicology]]

Danbot: Add Osmolal Gap calculator (collapsible)

2026-03-21T13:52:49Z

Add Osmolal Gap calculator (collapsible)

← Revisión anterior		Revisión del 13:52 21 mar 2026
Línea 120:		Línea 120:
	==References==		==References==
	<references/>		<references/>

			<div class="mw-collapsible mw-collapsed" style="border:1px solid #aaa; padding:5px; margin-top:10px;">
			<div style="font-weight:bold;">📊 Osmolal Gap Calculator [show]</div>
			<div class="mw-collapsible-content">
			{{Osmolal_Gap_Calculator}}
			</div>
			</div>
	[[Category:Toxicology]]		[[Category:Toxicology]]

Danbot: Fix drug name: use canonical Leucovorin instead of non-existent Folinic acid

2026-03-20T17:45:17Z

Fix drug name: use canonical Leucovorin instead of non-existent Folinic acid

← Revisión anterior		Revisión del 17:45 20 mar 2026
Línea 111:		Línea 111:
	*{{MedicationDose\|drug=Fomepizole\|dose=15 mg/kg IV load, then 10 mg/kg q12hr\|route=IV\|context=ADH inhibitor (1st line antidote)\|indication=Methanol toxicity\|population=Adult\|notes=Until level <20 mg/dL or acidosis resolves}}		*{{MedicationDose\|drug=Fomepizole\|dose=15 mg/kg IV load, then 10 mg/kg q12hr\|route=IV\|context=ADH inhibitor (1st line antidote)\|indication=Methanol toxicity\|population=Adult\|notes=Until level <20 mg/dL or acidosis resolves}}
	*{{MedicationDose\|drug=Sodium bicarbonate\|dose=1-2 mEq/kg IV bolus\|route=IV\|context=Correction of metabolic acidosis\|indication=Methanol toxicity\|population=Adult\|notes=Target pH 7.45-7.50; follow with infusion 150 mEq/L in D5W}}		*{{MedicationDose\|drug=Sodium bicarbonate\|dose=1-2 mEq/kg IV bolus\|route=IV\|context=Correction of metabolic acidosis\|indication=Methanol toxicity\|population=Adult\|notes=Target pH 7.45-7.50; follow with infusion 150 mEq/L in D5W}}
	*{{MedicationDose\|drug=~~Folinic acid~~\|dose=50 mg q4hr\|route=IV\|context=Enhanced formic acid metabolism\|indication=Methanol toxicity\|population=Adult\|notes=Facilitates breakdown of formic acid to CO2 and water}}		*{{MedicationDose\|drug=Leucovorin\|dose=50 mg q4hr\|route=IV\|context=Enhanced formic acid metabolism\|indication=Methanol toxicity\|population=Adult\|notes=Facilitates breakdown of formic acid to CO2 and water}}

	==See Also==		==See Also==

Danbot: Add MedicationDose SMW entries for fomepizole, sodium bicarbonate, folinic acid; doses verified against standard toxicology references

2026-03-20T17:37:00Z

Add MedicationDose SMW entries for fomepizole, sodium bicarbonate, folinic acid; doses verified against standard toxicology references

← Revisión anterior		Revisión del 17:37 20 mar 2026
Línea 106:		Línea 106:
	==Disposition==		==Disposition==
	*Consult toxicologist and/or [[poison control]]		*Consult toxicologist and/or [[poison control]]


			==Medication Dosing==
			*{{MedicationDose\|drug=Fomepizole\|dose=15 mg/kg IV load, then 10 mg/kg q12hr\|route=IV\|context=ADH inhibitor (1st line antidote)\|indication=Methanol toxicity\|population=Adult\|notes=Until level <20 mg/dL or acidosis resolves}}
			*{{MedicationDose\|drug=Sodium bicarbonate\|dose=1-2 mEq/kg IV bolus\|route=IV\|context=Correction of metabolic acidosis\|indication=Methanol toxicity\|population=Adult\|notes=Target pH 7.45-7.50; follow with infusion 150 mEq/L in D5W}}
			*{{MedicationDose\|drug=Folinic acid\|dose=50 mg q4hr\|route=IV\|context=Enhanced formic acid metabolism\|indication=Methanol toxicity\|population=Adult\|notes=Facilitates breakdown of formic acid to CO2 and water}}

	==See Also==		==See Also==

Elcatracho: /* Dialysis */

2022-01-12T15:24:19Z

Dialysis

← Revisión anterior		Revisión del 15:24 12 ene 2022
Línea 93:		Línea 93:
	===Dialysis===		===Dialysis===
	Indications:		Indications:
	#Refractory metabolic acidosis (pH <7.25) with AG >30		#Refractory [[metabolic acidosis]] (pH <7.25) with AG >30
	#Renal insufficiency		#Renal insufficiency
	#Visual symptoms		#Visual symptoms
Línea 99:		Línea 99:
	#Electrolyte abnormalities refractory to conventional therapy		#Electrolyte abnormalities refractory to conventional therapy
	#Methanol level >50mg/dL (controversial)		#Methanol level >50mg/dL (controversial)

	===Enchanced formic acid metabolism===		===Enchanced formic acid metabolism===
	#Folinic acid 50mg IV q4hr		#Folinic acid 50mg IV q4hr

Elcatracho: /* Correction of metabolic acidosis */

2022-01-12T15:23:39Z

Correction of metabolic acidosis

← Revisión anterior		Revisión del 15:23 12 ene 2022
Línea 86:		Línea 86:
	*Disadvantages: makes patients inebriated thus requiring close monitoring for CNS and respiratory depression, individual metabolic variations make dosing complicated, frequent serum level monitoring and dosage adjustments are required, administration of the 10% IV ethanol solution requires central venous access		*Disadvantages: makes patients inebriated thus requiring close monitoring for CNS and respiratory depression, individual metabolic variations make dosing complicated, frequent serum level monitoring and dosage adjustments are required, administration of the 10% IV ethanol solution requires central venous access
	===Correction of metabolic acidosis===		===Correction of metabolic acidosis===
	Profound acidemia is corrected with [[sodium bicarbonate]]		Profound [[acidemia]] is corrected with [[sodium bicarbonate]]
	*Bicarbonate 1-2mEq/kg IV bolus to attain pH = 7.45-7.50		*Bicarbonate 1-2mEq/kg IV bolus to attain pH = 7.45-7.50
	*Follow by infusion of 150mEq/L in D5 at 1.5-2x maintenance fluid rate		*Follow by infusion of 150mEq/L in D5 at 1.5-2x maintenance fluid rate

Elcatracho: /* Correction of metabolic acidosis */

2022-01-12T15:23:10Z

Correction of metabolic acidosis

← Revisión anterior		Revisión del 15:23 12 ene 2022
Línea 86:		Línea 86:
	*Disadvantages: makes patients inebriated thus requiring close monitoring for CNS and respiratory depression, individual metabolic variations make dosing complicated, frequent serum level monitoring and dosage adjustments are required, administration of the 10% IV ethanol solution requires central venous access		*Disadvantages: makes patients inebriated thus requiring close monitoring for CNS and respiratory depression, individual metabolic variations make dosing complicated, frequent serum level monitoring and dosage adjustments are required, administration of the 10% IV ethanol solution requires central venous access
	===Correction of metabolic acidosis===		===Correction of metabolic acidosis===
	Profound acidemia is corrected with sodium bicarbonate		Profound acidemia is corrected with [[sodium bicarbonate]]
	*Bicarbonate 1-2mEq/kg IV bolus to attain pH = 7.45-7.50		*Bicarbonate 1-2mEq/kg IV bolus to attain pH = 7.45-7.50
	*Follow by infusion of 150mEq/L in D5 at 1.5-2x maintenance fluid rate		*Follow by infusion of 150mEq/L in D5 at 1.5-2x maintenance fluid rate
	*Monitor for worsening hypocalcemia		*Monitor for worsening hypocalcemia

	===Dialysis===		===Dialysis===
	Indications:		Indications:

Elcatracho: /* Evaluation */

2021-03-09T20:29:13Z

Evaluation

← Revisión anterior		Revisión del 20:29 9 mar 2021
Línea 65:		Línea 65:
	*Ethanol level		*Ethanol level
	*VBG		*VBG

			{{Toxic Alcohols Anion/Osmolar Gaps}}

	==Management==		==Management==

Elcatracho: /* See Also */

2021-02-20T18:54:51Z

Elcatracho: /* Disposition */

2021-02-10T20:40:52Z

Disposition

← Revisión anterior		Revisión del 20:40 10 feb 2021
Línea 101:		Línea 101:

	==Disposition==		==Disposition==
	*Consult toxicologist and/or [[[[poison control]]]]		*Consult toxicologist and/or [[poison control]]

	==See Also==		==See Also==

← Revisión anterior		Revisión del 18:54 20 feb 2021
Línea 106:		Línea 106:
	*[[Ethylene Glycol Toxicity]]		*[[Ethylene Glycol Toxicity]]
	*[[Toxic Alcohols]]		*[[Toxic Alcohols]]
			*[[In-Training Exam Review]]

	==References==		==References==
	<references/>		<references/>
	[[Category:Toxicology]]		[[Category:Toxicology]]