Meloxicam - Revision history

Elcatracho: /* Pharmacology */

2021-03-07T22:56:19Z

Pharmacology

← Revisión anterior		Revisión del 22:56 7 mar 2021
Línea 79:		Línea 79:
	*Metabolism: liver extensively; CYP450 (2C9, 3A4 substrate)		*Metabolism: liver extensively; CYP450 (2C9, 3A4 substrate)
	*Excretion: urine (0.2% unchanged); feces (1.6% unchanged)		*Excretion: urine (0.2% unchanged); feces (1.6% unchanged)
	*Mechanism of Action: exact MOA unknown; inhibits ~~cyclooxyrgenase~~, reducing prostaglandin and thromboxane synthesis		*Mechanism of Action: exact MOA unknown; inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis

	==Comments==		==Comments==

Elcatracho: /* See Also */

2021-03-07T22:56:02Z

Elcatracho: /* Juvenile idiopathic arthritis (>60kg) */

2021-03-07T22:55:32Z

Juvenile idiopathic arthritis (>60kg)

← Revisión anterior		Revisión del 22:55 7 mar 2021
Línea 15:		Línea 15:

	==Pediatric Dosing==		==Pediatric Dosing==
	===[[Juvenile idiopathic arthritis (>60kg)]]===		===[[Juvenile idiopathic arthritis]](>60kg)===
	*7.5mg PO QD		*7.5mg PO QD
	*Max 7.5mg/day		*Max 7.5mg/day

Neil.m.young: Text replacement - "pruritis" to "pruritus"

2016-10-27T17:08:25Z

Text replacement - "pruritis" to "pruritus"

← Revisión anterior		Revisión del 17:08 27 oct 2016
Línea 65:		Línea 65:
	*headache, dizziness, drowsiness, tinnitus		*headache, dizziness, drowsiness, tinnitus
	*dizziness		*dizziness
	*rash, ~~pruritis~~, urticaria, photosensitivity		*rash, pruritus, urticaria, photosensitivity
	*fluid retention, peripheral edema		*fluid retention, peripheral edema
	*ecchymosis		*ecchymosis

Rossdonaldson1: /* Pediatric Dosing */

2016-09-27T17:24:55Z

Pediatric Dosing

← Revisión anterior		Revisión del 17:24 27 sep 2016
Línea 15:		Línea 15:

	==Pediatric Dosing==		==Pediatric Dosing==
	Juvenile idiopathic arthritis (>60kg)		===[[Juvenile idiopathic arthritis (>60kg)]]===
	*7.5mg PO QD		*7.5mg PO QD
	*Max 7.5mg/day		*Max 7.5mg/day

Rossdonaldson1: /* Adult Dosing */

2016-09-27T17:24:40Z

Adult Dosing

← Revisión anterior		Revisión del 17:24 27 sep 2016
Línea 6:		Línea 6:

	==Adult Dosing==		==Adult Dosing==
	Osteoarthritis		===[[Osteoarthritis]]===
	*7.5-15mg PO QD		*7.5-15mg PO QD
	*Max 15mg/day		*Max 15mg/day

	Rheumatoid arthritis		===[[Rheumatoid arthritis]]===
	*7.5-15mg PO QD		*7.5-15mg PO QD
	*Max 15mg/day		*Max 15mg/day

ClaireLewis at 00:45, 27 September 2016

2016-09-27T00:45:01Z

← Revisión anterior		Revisión del 00:45 27 sep 2016
Línea 41:		Línea 41:
	*Allergy to class/drug		*Allergy to class/drug
	*ASA or NSAID-induced asthma or urticaria		*ASA or NSAID-induced asthma or urticaria
	*~~pregnancy starting at 30wk gestation~~		*caution if:
	*~~CABG surgery period use~~		**renal impairment, dehydration, elderly or debilitated
	*~~caution in~~ elderly or debilitated ~~patients~~		**history of GI bleed or ulcers, alcohol use, or coagulopathy
	*~~caution if renal impairment~~		**hepatic impairment
	*~~caution if~~ hepatic impairment		**asthma
	*~~caution if~~ asthma		**cardiovascular disease (or high risk of), including CABG surgery periop use, recent MI, CHF, HTN, smoker
	*~~caution if recent MI~~		**fluid retention
	*~~caution if~~ cardiovascular dz		**PKU
	*caution if cardiac dz risk		**prolonged use
	*caution if HTN
	*~~caution if CHF~~
	*~~caution if~~ fluid retention
	*~~caution if GI bleeding or ulcer hx~~
	*~~caution if coagulation disorder~~
	*~~caution if dehydration~~
	*caution if hypovolemia
	*caution if smoker
	*caution if alcohol use
	*~~caution if~~ prolonged use

	==Adverse Reactions==		==Adverse Reactions==
	~~===~~Serious~~===~~		'''Serious'''
	*GI bleeding		*GI bleed, ulcer, perforation
	*~~GI perforation/ulcer~~		*blood dyscrasias, prolonged bleeding time, anemia
	*MI		*nephrotoxicity, renal papillary necrosis
	*stroke		*MI, stroke, thromboembolism, HTN, CHF
	*thromboembolism		*hepatotoxicity, hepatic necrosis, pancreatitis
	*HTN
	*CHF
	*~~renal papillary~~ necrosis
	*nephrotoxicity
	*hyperkalemia
	*hepatotoxicity
	*pancreatitis
	*anaphylactoid rxn
	*bronchospasm		*bronchospasm
	*exfoliative dermatitis		*exfoliative dermatitis, SJS/TEN
	*Stevens-Johnson syndrome
	*toxic epidermal necrolysis
	*anemia
	*blood dyscrasias

	~~===~~Common~~===~~		'''Common'''
	*diarrhea		*dyspepsia, nausea/vomiting, abdominal pain, diarrhea, constipation, flatulence
	*nausea		*headache, dizziness, drowsiness, tinnitus
	*abdominal pain
	*~~dyspepsia~~
	*rash
	*urticaria
	*dizziness		*dizziness
	*~~somnolence~~		*rash, pruritis, urticaria, photosensitivity
	*ALT/AST elevation		*fluid retention, peripheral edema
	*fluid retention
	*edema
	*tinnitus
	*ecchymosis		*ecchymosis
	*~~photosensitivity~~		*elevated creatinine, ALT/AST
			*sinusitis
	*vomiting (peds)		*vomiting (peds)
	*headache (peds)		*headache (peds)

Kaoru: Created page with "==Administration== Type: NSAID Dosage Forms: 7.5, 15mg Routes of Administration: PO Common Trade Names: Mobic, Vivlodex ==Adult Dosing== Osteoarthritis *7.5-15mg PO Q..."

2016-09-26T20:34:29Z

Created page with "==Administration== *Type: NSAID *Dosage Forms: 7.5, 15mg *Routes of Administration: PO *Common Trade Names: Mobic, Vivlodex ==Adult Dosing== Osteoarthritis *7.5-15mg PO Q..."

Página nueva

==Administration==
*Type: [[NSAID]]
*Dosage Forms: 7.5, 15mg
*Routes of Administration: PO
*Common Trade Names: Mobic, Vivlodex

==Adult Dosing==
Osteoarthritis
*7.5-15mg PO QD
*Max 15mg/day

Rheumatoid arthritis
*7.5-15mg PO QD
*Max 15mg/day

==Pediatric Dosing==
Juvenile idiopathic arthritis (>60kg)
*7.5mg PO QD
*Max 7.5mg/day

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C, category D if >30wk gestation
*[[Lactation risk categories|Lactation risk]]: safety unknown, inadequate literature available to assess risk

===Renal Dosing===
*Adult:
**mild-mod impairment: no adjustment
**CrCl <15: avoid use
**HD: max 7.5mg/day

*Pediatric: see Adult dosing

===Hepatic Dosing===
*Adult:
**Child-Pugh Class A or B: no adjustment
**Child-Pugh Class: not defined

*Pediatric: see Adult Dosing

==Contraindications==
*Allergy to class/drug
*ASA or NSAID-induced asthma or urticaria
*pregnancy starting at 30wk gestation
*CABG surgery period use
*caution in elderly or debilitated patients
*caution if renal impairment
*caution if hepatic impairment
*caution if asthma
*caution if recent MI
*caution if cardiovascular dz
*caution if cardiac dz risk
*caution if HTN
*caution if CHF
*caution if fluid retention
*caution if GI bleeding or ulcer hx
*caution if coagulation disorder
*caution if dehydration
*caution if hypovolemia
*caution if smoker
*caution if alcohol use
*caution if prolonged use

==Adverse Reactions==
===Serious===
*GI bleeding
*GI perforation/ulcer
*MI
*stroke
*thromboembolism
*HTN
*CHF
*renal papillary necrosis
*nephrotoxicity
*hyperkalemia
*hepatotoxicity
*pancreatitis
*anaphylactoid rxn
*bronchospasm
*exfoliative dermatitis
*Stevens-Johnson syndrome
*toxic epidermal necrolysis
*anemia
*blood dyscrasias

===Common===
*diarrhea
*nausea
*abdominal pain
*dyspepsia
*rash
*urticaria
*dizziness
*somnolence
*ALT/AST elevation
*fluid retention
*edema
*tinnitus
*ecchymosis
*photosensitivity
*vomiting (peds)
*headache (peds)
*fever (peds)
*delayed ovulation

==Pharmacology==
*Half-life: 15-20 hours
*Metabolism: liver extensively; CYP450 (2C9, 3A4 substrate)
*Excretion: urine (0.2% unchanged); feces (1.6% unchanged)
*Mechanism of Action: exact MOA unknown; inhibits cyclooxyrgenase, reducing prostaglandin and thromboxane synthesis

==Comments==

==See Also==
[[NSAID]]

==References==
<references/>
[[Category:Pharmacology]]

← Revisión anterior		Revisión del 22:56 7 mar 2021
Línea 84:		Línea 84:

	==See Also==		==See Also==
	[[NSAID]]		*[[NSAID]]
			*[[NSAID toxicity]]

	==References==		==References==
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]