Marburg virus disease - Revision history

Neil.m.young: Text replacement - "==Diagnostic Evaluation==" to "==Evaluation=="

2016-07-28T04:14:04Z

Text replacement - "==Diagnostic Evaluation==" to "==Evaluation=="

← Revisión anterior		Revisión del 04:14 28 jul 2016
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	*[[Q fever]]		*[[Q fever]]

	==~~Diagnostic~~ Evaluation==		==Evaluation==
	*Difficult diagnosis and very rare/unlikely outside of Central Africa		*Difficult diagnosis and very rare/unlikely outside of Central Africa
	*Consider Marburg with typical symptoms and high risk exposure including:		*Consider Marburg with typical symptoms and high risk exposure including:

Ostermayer: Text replacement - "Category:TropMed" to "Category:Tropical Medicine"

2016-03-22T16:59:08Z

Text replacement - "Category:TropMed" to "Category:Tropical Medicine"

← Revisión anterior		Revisión del 16:59 22 mar 2016
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	[[Category:ID]]		[[Category:ID]]
	[[Category:~~TropMed~~]]		[[Category:Tropical Medicine]]

Mholtz at 07:19, 7 September 2015

2015-09-07T07:19:11Z

← Revisión anterior		Revisión del 07:19 7 sep 2015
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	**The 5 species of Ebola are the other 5 members of the family		**The 5 species of Ebola are the other 5 members of the family
	*First outbreak, 1967, in Marburg and Frankfurt Germany - due to research on African green monkeys		*First outbreak, 1967, in Marburg and Frankfurt Germany - due to research on African green monkeys
	*Reservoir: ~~African~~ fruit bat (''Rousettus aegyptiacus'')		*Reservoir: Egyptian fruit bat (''Rousettus aegyptiacus'')

	===Transmission===		===Transmission===
	*Host animal to human - most outbreaks have implicated contact with bats<ref name="Pigott">Pigott DM, Golding N, Mylne A, et al. Mapping the zoonotic niche of Marburg virus disease in Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2015;109(6):366-378. doi:10.1093/trstmh/trv024.</ref>		*Host animal to human - most outbreaks have implicated contact with bats as the source<ref name="Pigott">Pigott DM, Golding N, Mylne A, et al. Mapping the zoonotic niche of Marburg virus disease in Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2015;109(6):366-378. doi:10.1093/trstmh/trv024.</ref>
	**No documented cases of primate-human transmission outside laboratory setting		**No documented cases of primate-human transmission outside laboratory setting
	*Human to human: direct contact with droplets of body fluid or contaminated objects		*Human to human: direct contact with droplets of body fluid or contaminated objects
			**Humans can transmit the virus as soon as they are febrile.<ref name="Martines">Martines RB, Ng DL, Greer PW, Rollin PE, Zaki SR. Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses. J Pathol. 2015 Jan;235(2):153-74. doi: 10.1002/path.4456.</ref>

	==Clinical Features==		==Clinical Features==
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	**Maculopapular rash, typically on the trunk, around 5 days after symptom onset		**Maculopapular rash, typically on the trunk, around 5 days after symptom onset
	*Massive hemorrhage, shock, and multiorgan system failure		*Massive hemorrhage, shock, and multiorgan system failure
	*Death usually occurs 1-2 weeks after symptom onset<ref name="Bebell" /> (23-90% fatal)		*Death usually occurs 1-2 weeks after symptom onset<ref name="Bebell" /> (23-90% fatal<ref name="Knust">Knust B, Schafer IJ, Wamala J, et al. Multidistrict Outbreak of Marburg Virus Disease-Uganda, 2012. J Infect Dis. 2015 Jul 23. pii: jiv351.</ref>)
	**Patients alive at 2 weeks after symptom onset usually survive		**Patients alive at 2 weeks after symptom onset usually survive

Mholtz at 07:02, 7 September 2015

2015-09-07T07:02:29Z

← Revisión anterior		Revisión del 07:02 7 sep 2015
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	===Work-up===		===Work-up===
	*~~ELISA,~~ PCR, and IgM ELISA for acute infection several days after symptom onset.<ref name="Bebell" />		*PCR and IgM ELISA for acute infection several days after symptom onset.<ref name="Bebell" />
	*IgG ELISA can be used later in the course of disease.		*IgG ELISA can be used later in the course of disease.

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	==See Also==		==See Also==
	*[[Fever in ~~travelers~~]]		*[[Ebola virus disease]]
			*[[Viral hemorrhagic fevers]]
			*[[Fever in traveler]]
	*[[Travel medicine]]		*[[Travel medicine]]
	*[[Viral hemorrhagic fevers]]
	*[[Ebola]]

	==External Links==		==External Links==

Mholtz at 07:01, 7 September 2015

2015-09-07T07:01:16Z

← Revisión anterior		Revisión del 07:01 7 sep 2015
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	==Clinical Features==		==Clinical Features==
	*Incubation period: 5-10 ~~days~~		*Incubation period: 2-21 days (5-7 days more common)<ref name="Bebell">Bebell LM, Riley LE. Ebola virus disease and Marburg disease in pregnancy: a review and management considerations for filovirus infection. Obstet Gynecol. 2015 Jun;125(6):1293-8. doi: 10.1097/AOG.0000000000000853.</ref>
	*Initial symptoms are vague:		*Initial symptoms are vague:
	**~~Fever~~, headache, chills, myalgias, abdominal pain, diarrhea		**High fever, headache, chills, myalgias, abdominal pain, diarrhea
	**Maculopapular rash, typically on the trunk, around 5 days after symptom onset		**Maculopapular rash, typically on the trunk, around 5 days after symptom onset
	*Massive hemorrhage, shock, and multiorgan system failure		*Massive hemorrhage, shock, and multiorgan system failure
	*23-90% fatal		*Death usually occurs 1-2 weeks after symptom onset<ref name="Bebell" /> (23-90% fatal)
			**Patients alive at 2 weeks after symptom onset usually survive

	==Differential Diagnosis==		==Differential Diagnosis==
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	===Work-up===		===Work-up===
	*ELISA, PCR, and IgM ELISA for acute infection several days after symptom onset.		*ELISA, PCR, and IgM ELISA for acute infection several days after symptom onset.<ref name="Bebell" />
	*IgG ELISA can be used later in the course of disease.		*IgG ELISA can be used later in the course of disease.

	==Management==		==Management==
	*~~Supportive therapies are~~ the hallmark of management		*Aggressive supportive care is the hallmark of management<ref name="Bebell" />
	*[[Isolation precautions]]: standard, contact and droplet<ref name="CAHealth">California Health Alert Network. Alert Id: 35317. 9/10/2014</ref>		*Strict [[Isolation precautions]]: standard, contact and droplet<ref name="CAHealth">California Health Alert Network. Alert Id: 35317. 9/10/2014</ref>
	**Isolate in a single room with the door closed
	**Limit entry and maintain a log of people who enter the room		**Limit entry and maintain a log of people who enter the room
	**Use standard, contact, and droplet precautions
	*Notify public health personnel		*Notify public health personnel
	*Continue to test and treat for other possible diseases		*Continue to test and treat for other possible diseases

Mholtz at 06:53, 7 September 2015

2015-09-07T06:53:53Z

← Revisión anterior		Revisión del 06:53 7 sep 2015
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	**The 5 species of Ebola are the other 5 members of the family		**The 5 species of Ebola are the other 5 members of the family
	*First outbreak, 1967, in Marburg and Frankfurt Germany - due to research on African green monkeys		*First outbreak, 1967, in Marburg and Frankfurt Germany - due to research on African green monkeys
	*Reservoir: African fruit bat, Rousettus aegyptiacus		*Reservoir: African fruit bat (''Rousettus aegyptiacus'')

	===Transmission===		===Transmission===
	*Host animal to human ~~unknown. Likely;~~ contact with ~~infected bat feces or aerosols~~, ~~handling infected primates or their tissues~~		*Host animal to human - most outbreaks have implicated contact with bats<ref name="Pigott">Pigott DM, Golding N, Mylne A, et al. Mapping the zoonotic niche of Marburg virus disease in Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2015;109(6):366-378. doi:10.1093/trstmh/trv024.</ref>
			**No documented cases of primate-human transmission outside laboratory setting
	*Human to human: direct contact with droplets of body fluid or contaminated objects		*Human to human: direct contact with droplets of body fluid or contaminated objects

Mholtz: Mholtz moved page Marburg to Marburg virus disease

2015-09-07T06:38:07Z

Mholtz moved page Marburg to Marburg virus disease

← Revisión anterior	Revisión del 06:38 7 sep 2015
(Sin diferencias)

Mholtz at 06:37, 7 September 2015

2015-09-07T06:37:41Z

← Revisión anterior		Revisión del 06:37 7 sep 2015
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	==Background==		==Background==
	*RNA ~~based~~ virus of the [[Filovirus\|filovirus]] family		*Also known as Marburg [[Viral hemorrhagic fevers\|hemorrhagic fever]]
	**~~the~~ 5 species of Ebola are the other 5 members of the family		*RNA virus of the [[Filovirus\|filovirus]] family
	*First outbreak, 1967, in Marburg and Frankfurt Germany- due to research on African green monkeys		**The 5 species of Ebola are the other 5 members of the family
			*First outbreak, 1967, in Marburg and Frankfurt Germany - due to research on African green monkeys
	*Reservoir: African fruit bat, Rousettus aegyptiacus		*Reservoir: African fruit bat, Rousettus aegyptiacus
	*[[Viral hemorrhagic fever]]

	==Transmission==		===Transmission===
	*Host animal to human unknown. Likely; contact with infected bat feces or aerosols, handling infected primates or their tissues		*Host animal to human unknown. Likely; contact with infected bat feces or aerosols, handling infected primates or their tissues
	*Human to human: direct contact with droplets of body fluid or contaminated objects		*Human to human: direct contact with droplets of body fluid or contaminated objects
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	*[[Q fever]]		*[[Q fever]]

	==~~Workup~~==		==Diagnostic Evaluation==
	*Difficult diagnosis and very rare/unlikely outside of Central Africa		*Difficult diagnosis and very rare/unlikely outside of Central Africa
	*Consider Marburg with typical symptoms and high risk exposure including:		*Consider Marburg with typical symptoms and high risk exposure including:
Línea 43:		Línea 43:
	**Cave exploration in Africa		**Cave exploration in Africa

	===~~Diagnostics~~===		===Work-up===
	ELISA, PCR, and IgM ELISA for acute infection several days after symptom onset. IgG ELISA can be used later in the course of disease.		*ELISA, PCR, and IgM ELISA for acute infection several days after symptom onset.
			*IgG ELISA can be used later in the course of disease.

	==Management==		==Management==
			*Supportive therapies are the hallmark of management
	*[[Isolation precautions]]: standard, contact and droplet<ref name="CAHealth">California Health Alert Network. Alert Id: 35317. 9/10/2014</ref>		*[[Isolation precautions]]: standard, contact and droplet<ref name="CAHealth">California Health Alert Network. Alert Id: 35317. 9/10/2014</ref>
	**Isolate in a single room with the door closed		**Isolate in a single room with the door closed
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	*Notify public health personnel		*Notify public health personnel
	*Continue to test and treat for other possible diseases		*Continue to test and treat for other possible diseases
	*Supportive management
	**Experimental treatment has never been used in humans

	==Disposition==		==Disposition==
	Admit~~, isolation, possible~~ ICU ~~for serologic results and clinical observation/supportive care.~~		*Admit to ICU

	==See Also==		==See Also==
	*[[Fever in ~~Travelers~~]]		*[[Fever in travelers]]
	*[[Travel ~~Medicine~~]]		*[[Travel medicine]]
	*[[Viral ~~Hemorrhagic Fevers~~]]		*[[Viral hemorrhagic fevers]]
	*[[Ebola]]		*[[Ebola]]

	==External Links==		==External Links==
			*[http://www.cdc.gov/vhf/marburg/index.html CDC Marburg Site]

	==~~Sources~~==		==References==
	~~#Marburg Hemorrhagic Fever http://www.cdc.gov/vhf/marburg/index.html~~
	<references/>		<references/>


	[[Category:ID]]		[[Category:ID]]
	[[Category:TropMed]]		[[Category:TropMed]]

Zipdoc at 15:24, 10 August 2015

2015-08-10T15:24:39Z

← Revisión anterior		Revisión del 15:24 10 ago 2015
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	==Background==		==Background==
	*RNA based virus of the filovirus family		*RNA based virus of the [[Filovirus\|filovirus]] family
	**the 5 species of Ebola are the other 5 members of the family		**the 5 species of Ebola are the other 5 members of the family
	*First outbreak, 1967, in Marburg and Frankfurt Germany- due to research on African green monkeys		*First outbreak, 1967, in Marburg and Frankfurt Germany- due to research on African green monkeys

Rossdonaldson1: /* Differential Diagnosis */

2015-06-10T02:35:46Z

Differential Diagnosis

← Revisión anterior		Revisión del 02:35 10 jun 2015
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	**[[Ebola]]		**[[Ebola]]
	**[[Lassa fever]]		**[[Lassa fever]]
			**[[Marburg]]
	*[[Chikungunya]]		*[[Chikungunya]]
	*[[Yellow fever]]		*[[Yellow fever]]