Lysergic acid diethylamide toxicity - Revision history

Elcatracho: /* Management */

2021-02-10T20:38:02Z

Management

← Revisión anterior		Revisión del 20:38 10 feb 2021
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	==Management==		==Management==
			*Principally supportive
	*Assess for signs of trauma or exposure		*Assess for signs of trauma or exposure
	*Assure patient and staff safety		*Assure patient and staff safety

Elcatracho: /* Clinical Features */

2021-02-10T20:37:13Z

Clinical Features

← Revisión anterior		Revisión del 20:37 10 feb 2021
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	*Dizziness		*Dizziness
	*Visual and auditory [[hallucinations]]		*Visual and auditory [[hallucinations]]
			*Synesthesia ("seeing sounds" and "hearing colors")
	*Paranoia		*Paranoia
	*Acute panic reactions / [[agitation]]		*Acute panic reactions / [[agitation]]

Rossdonaldson1: /* Differential Diagnosis */

2021-01-12T20:19:30Z

Differential Diagnosis

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 ==Differential Diagnosis==
 {{Hallucinogen types}}
 ==Evaluation==

Rossdonaldson1: /* Clinical Features */

2021-01-12T20:18:51Z

Clinical Features

← Revisión anterior		Revisión del 20:18 12 ene 2021
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	*Dizziness		*Dizziness
	*Visual and auditory [[hallucinations]]		*Visual and auditory [[hallucinations]]
	*Effects taper off after about 6-8 hours
	*Paranoia		*Paranoia
	*Acute panic reactions / [[agitation]]		*Acute panic reactions / [[agitation]]
			*Effects taper off after about 6-8 hours, depending on dose

	==Differential Diagnosis==		==Differential Diagnosis==

Rossdonaldson1: /* Clinical Features */

2021-01-12T20:18:29Z

Clinical Features

← Revisión anterior		Revisión del 20:18 12 ene 2021
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	*Dizziness		*Dizziness
	*Visual and auditory [[hallucinations]]		*Visual and auditory [[hallucinations]]
	*Effects taper off after about 6-8 hours ~~and are usually completely gone after a nights sleep."~~		*Effects taper off after about 6-8 hours
			*Paranoia
	~~"Good Trips" are much like what is described as above, with seemingly normal or usual objects and experiences appearing new and changed to something breath-taking.~~		*Acute panic reactions / [[agitation]]

	~~"Bad Trips" include experiences of paranoia, acute~~ panic reactions~~, and~~ agitation, usually stemming from the users prior mood to ingesting LSD. This, along with the user's altered perception of their environment, can lead to the user being subjected to dangers resulting in serious injury, disability, or death.

	==Differential Diagnosis==		==Differential Diagnosis==

Rossdonaldson1: /* Clinical Features */

2021-01-12T20:15:57Z

Clinical Features

← Revisión anterior		Revisión del 20:15 12 ene 2021
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	==Clinical Features==		==Clinical Features==
	~~The acute ingestion of LSD is described as:~~		*Effects begin around 20-40 minutes after injection
	~~"The initial effects~~ begin 20-40 minutes with a sense of euphoria and dizziness...LSD is best described as a drug that strikes down barriers. The person who uses LSD is likely to feel detached from his/her ego, and can cross between states of consciousness. The user's perceptions are altered, causing visual and auditory hallucinations. One may notice that the walls of room are "breathing" or that motionless curtains appear to be moving. Senses appear to mix: a user might see music, taste colors, or hear visual stimuli. The LSD experience is often difficult to describe by users -- words lose meaning and are often insufficient in describing the effects of the drug; thoughts may seem unclear. Effects taper off after about 6-8 hours and are usually completely gone after a nights sleep."~~<ref>https://www.erowid.org/chemicals/lsd/lsd_effects1.shtml</ref>~~		*Euphoria
			*Dizziness
			*Visual and auditory [[hallucinations]]
			*Effects taper off after about 6-8 hours and are usually completely gone after a nights sleep."

	"Good Trips" are much like what is described as above, with seemingly normal or usual objects and experiences appearing new and changed to something breath-taking.		"Good Trips" are much like what is described as above, with seemingly normal or usual objects and experiences appearing new and changed to something breath-taking.

Rossdonaldson1: /* Differential Diagnosis */

2021-01-12T20:13:06Z

Differential Diagnosis

← Revisión anterior		Revisión del 20:13 12 ene 2021
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	==Differential Diagnosis==		==Differential Diagnosis==
			{{Hallucinogen types}}

	===Serotonin-Like Agents===		===Serotonin-Like Agents===
	*LSD		*LSD

Rossdonaldson1: /* Background */

2021-01-12T20:12:19Z

Background

← Revisión anterior		Revisión del 20:12 12 ene 2021
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	===Mechanism===		===Mechanism===
	*Similar to chemical properties of serotonin		*Similar to chemical properties of serotonin
	**5-HT2 agonists, mediating excitatory neurotransmitter release.<ref>Ly, B. "Hallucinogens", ''Rosen's Emergency Medicine: Concepts and Clinical Practice''. 7th Ed. Pgs 2010-2012</ref> LSD also binds to dopaminergic receptors, contributing to its psychogenic affects.<ref>Marona-Lewicka D, Thisted RA, Nichols DE (2005). "Distinct temporal phases in the behavioral pharmacology of LSD: Dopamine D2 receptor-mediated effects in the rat and implications for psychosis". Psychopharmacology 180 (3): 427–435.</ref>		**5-HT2 agonists, mediating excitatory neurotransmitter release.<ref>Ly, B. "Hallucinogens", ''Rosen's Emergency Medicine: Concepts and Clinical Practice''. 7th Ed. Pgs 2010-2012</ref>
			*LSD also binds to dopaminergic receptors, contributing to its psychogenic affects.<ref>Marona-Lewicka D, Thisted RA, Nichols DE (2005). "Distinct temporal phases in the behavioral pharmacology of LSD: Dopamine D2 receptor-mediated effects in the rat and implications for psychosis". Psychopharmacology 180 (3): 427–435.</ref>

	===Pharmacology===		===Pharmacology===

Rossdonaldson1 at 20:12, 12 January 2021

2021-01-12T20:12:04Z

← Revisión anterior		Revisión del 20:12 12 ene 2021
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	==Background==		==Background==
	*Also known as d-lysergic acid diethylamide		*Also known as d-lysergic acid diethylamide and LSD

	===Mechanism===		===Mechanism===
	~~Serotonin-like agents, like LSD, have similar~~ chemical properties of serotonin~~. These are~~ 5-HT2 agonists, mediating excitatory neurotransmitter release.<ref>Ly, B. "Hallucinogens", ''Rosen's Emergency Medicine: Concepts and Clinical Practice''. 7th Ed. Pgs 2010-2012</ref> LSD also binds to dopaminergic receptors, contributing to its psychogenic affects.<ref>Marona-Lewicka D, Thisted RA, Nichols DE (2005). "Distinct temporal phases in the behavioral pharmacology of LSD: Dopamine D2 receptor-mediated effects in the rat and implications for psychosis". Psychopharmacology 180 (3): 427–435.</ref>		*Similar to chemical properties of serotonin
			**5-HT2 agonists, mediating excitatory neurotransmitter release.<ref>Ly, B. "Hallucinogens", ''Rosen's Emergency Medicine: Concepts and Clinical Practice''. 7th Ed. Pgs 2010-2012</ref> LSD also binds to dopaminergic receptors, contributing to its psychogenic affects.<ref>Marona-Lewicka D, Thisted RA, Nichols DE (2005). "Distinct temporal phases in the behavioral pharmacology of LSD: Dopamine D2 receptor-mediated effects in the rat and implications for psychosis". Psychopharmacology 180 (3): 427–435.</ref>

	===Pharmacology===		===Pharmacology===

Rossdonaldson1: Rossdonaldson1 moved page Lysergic acid diethylamide to Lysergic acid diethylamide toxicity

2021-01-12T20:08:45Z

Rossdonaldson1 moved page Lysergic acid diethylamide to Lysergic acid diethylamide toxicity

← Revisión anterior	Revisión del 20:08 12 ene 2021
(Sin diferencias)