Lymphatic filariasis - Revision history

Ostermayer: /* Diethylcarbamazine (DEC) */

2022-04-03T13:12:32Z

Diethylcarbamazine (DEC)

← Revisión anterior		Revisión del 13:12 3 abr 2022
Línea 28:		Línea 28:
	==Management==		==Management==
	*Meticulous skin care to prevent superinfection/cellulitis		*Meticulous skin care to prevent superinfection/cellulitis
	===Diethylcarbamazine (DEC)===		===[[Diethylcarbamazine]] (DEC)===
	{{filariasis dec treatment}}		{{filariasis dec treatment}}

	===Ivermectin + Albendazole===		===Ivermectin + Albendazole===
	*Combined treatment with diethylcarbamazine/albendazole may be more effective than single drug treatment		*Combined treatment with diethylcarbamazine/albendazole may be more effective than single drug treatment

Ostermayer: /* Management */

2022-04-03T13:11:40Z

Management

← Revisión anterior		Revisión del 13:11 3 abr 2022
Línea 27:		Línea 27:

	==Management==		==Management==
	*Diethylcarbamazine (DEC):		*Meticulous skin care to prevent superinfection/cellulitis
			===Diethylcarbamazine (DEC)===
	{{filariasis dec treatment}}		{{filariasis dec treatment}}
	*Ivermectin + Albendazole		===Ivermectin + Albendazole===
	*Combined treatment with diethylcarbamazine/albendazole may be more effective than single drug treatment		*Combined treatment with diethylcarbamazine/albendazole may be more effective than single drug treatment
	*Meticulous skin care to prevent superinfection/cellulitis		===Surgical===
	*Surgical management of scrotal elephantiasis and chronic lymphatic obstruction		*Surgical management of scrotal elephantiasis and chronic lymphatic obstruction

Ostermayer: /* Management */

2022-04-03T13:07:57Z

Management

← Revisión anterior		Revisión del 13:07 3 abr 2022
Línea 28:		Línea 28:
	==Management==		==Management==
	*Diethylcarbamazine (DEC):		*Diethylcarbamazine (DEC):
	**Day 1: 50mg PO		{{filariasis dec treatment}}
	**Day 2: 50mg TID
	**Day 3: 100mg TID
	**Days 4-21: 6mg/kg/day divided TID
	*Ivermectin + Albendazole		*Ivermectin + Albendazole
	*Combined treatment with diethylcarbamazine/albendazole may be more effective than single drug treatment		*Combined treatment with diethylcarbamazine/albendazole may be more effective than single drug treatment

Neil.m.young: Text replacement - "==Diagnostic Evaluation==" to "==Evaluation=="

2016-07-28T03:55:22Z

Text replacement - "==Diagnostic Evaluation==" to "==Evaluation=="

← Revisión anterior		Revisión del 03:55 28 jul 2016
Línea 18:		Línea 18:


	==~~Diagnostic~~ Evaluation==		==Evaluation==
	*Establish possible exposure in endemic areas		*Establish possible exposure in endemic areas
	*Serology (peripheral blood) - draw at night due to periodicity of filiariae		*Serology (peripheral blood) - draw at night due to periodicity of filiariae

Neil.m.young: Text replacement - "6 mg" to "6mg"

2016-07-25T06:30:43Z

Text replacement - "6 mg" to "6mg"

← Revisión anterior		Revisión del 06:30 25 jul 2016
Línea 31:		Línea 31:
	**Day 2: 50mg TID		**Day 2: 50mg TID
	**Day 3: 100mg TID		**Day 3: 100mg TID
	**Days 4-21: ~~6 mg~~/kg/day divided TID		**Days 4-21: 6mg/kg/day divided TID
	*Ivermectin + Albendazole		*Ivermectin + Albendazole
	*Combined treatment with diethylcarbamazine/albendazole may be more effective than single drug treatment		*Combined treatment with diethylcarbamazine/albendazole may be more effective than single drug treatment

Neil.m.young: Text replacement - "0 mg" to "0mg"

2016-07-19T10:35:52Z

Text replacement - "0 mg" to "0mg"

← Revisión anterior		Revisión del 10:35 19 jul 2016
Línea 28:		Línea 28:
	==Management==		==Management==
	*Diethylcarbamazine (DEC):		*Diethylcarbamazine (DEC):
	**Day 1: ~~50 mg~~ PO		**Day 1: 50mg PO
	**Day 2: ~~50 mg~~ TID		**Day 2: 50mg TID
	**Day 3: ~~100 mg~~ TID		**Day 3: 100mg TID
	**Days 4-21: 6 mg/kg/day divided TID		**Days 4-21: 6 mg/kg/day divided TID
	*Ivermectin + Albendazole		*Ivermectin + Albendazole

Ostermayer: Text replacement - "Category:TropMed" to "Category:Tropical Medicine"

2016-03-22T16:59:11Z

Text replacement - "Category:TropMed" to "Category:Tropical Medicine"

← Revisión anterior		Revisión del 16:59 22 mar 2016
Línea 52:		Línea 52:

	[[Category:ID]]		[[Category:ID]]
	[[Category:~~TropMed~~]]		[[Category:Tropical Medicine]]

Mholtz at 10:03, 6 September 2015

2015-09-06T10:03:36Z

← Revisión anterior		Revisión del 10:03 6 sep 2015
Línea 12:		Línea 12:
	==Clinical Features==		==Clinical Features==
	*2/3 will be asymptomatic<ref name="Taylor">Mark J Taylor, Achim Hoerauf, Moses Bockarie. Lymphatic filariasis and onchocerciasis. Lancet 2010; 376: 1175–85</ref>		*2/3 will be asymptomatic<ref name="Taylor">Mark J Taylor, Achim Hoerauf, Moses Bockarie. Lymphatic filariasis and onchocerciasis. Lancet 2010; 376: 1175–85</ref>
	*~~Massive~~ peripheral edema with thickening of overlying skin particularly in lower extremities and genitalia		*Chronic infection leads to massive peripheral edema with thickening of overlying skin particularly in lower extremities and genitalia
	*Recurrent [[cellulitis]] is common		*Recurrent [[cellulitis]] is common

Línea 27:		Línea 27:

	==Management==		==Management==
	*Diethylcarbamazine:		*Diethylcarbamazine (DEC):
	**Day 1: 50 mg PO		**Day 1: 50 mg PO
	**Day 2: 50 mg TID		**Day 2: 50 mg TID
	**Day 3: 100 mg TID		**Day 3: 100 mg TID
	**Days 4-21: 6 mg/kg/day divided TID		**Days 4-21: 6 mg/kg/day divided TID
	*Combined treatment with diethylcarbamazine~~/albendazole or ivermectin~~/albendazole may be more effective		*Ivermectin + Albendazole
			*Combined treatment with diethylcarbamazine/albendazole may be more effective than single drug treatment
	*Meticulous skin care to prevent superinfection/cellulitis		*Meticulous skin care to prevent superinfection/cellulitis
	*Surgical management of scrotal elephantiasis and chronic lymphatic obstruction		*Surgical management of scrotal elephantiasis and chronic lymphatic obstruction

	==Disposition==		==Disposition==
			*Generally may be discharged unless complicated by other factors.

	==See Also==		==See Also==

Mholtz at 09:56, 6 September 2015

2015-09-06T09:56:16Z

← Revisión anterior		Revisión del 09:56 6 sep 2015
Línea 1:		Línea 1:
	==Background==		==Background==
	*Also known as elephantiasis		*Also known as elephantiasis
	*Causative agents:		*Causative agents (transmitted by mosquito):
	**''Wuchereria bancrofti''		**''Wuchereria bancrofti''
	**''Brugia malayi''		**''Brugia malayi''
	**''Brugia timori''		**''Brugia timori''
	*Larvae migrate to lymphatic vessels and mature into adults		*No known natural animal reservoir<ref name="Chandy">Chandy A, Thakur AS, Singh MP, Manigauha A. A review of neglected tropical diseases: filariasis. Asian Pac J Trop Med. 2011 Jul;4(7):581-6. doi: 10.1016/S1995-7645(11)60150-8.</ref>
			*Larvae migrate to lymphatic vessels and mature into adults (can take 6-12 months<ref name="Chandy" />)
			**These worms block lymphatic vessels, which causes the clinical presentation of the disease
			*Coinfection is common (filiariae cause immunosuppression and allows for malaria and/or TB to thrive)

	==Clinical Features==		==Clinical Features==
			*2/3 will be asymptomatic<ref name="Taylor">Mark J Taylor, Achim Hoerauf, Moses Bockarie. Lymphatic filariasis and onchocerciasis. Lancet 2010; 376: 1175–85</ref>
	*Massive peripheral edema with thickening of overlying skin particularly in lower extremities and genitalia		*Massive peripheral edema with thickening of overlying skin particularly in lower extremities and genitalia
	*Recurrent [[cellulitis]] is common		*Recurrent [[cellulitis]] is common
Línea 15:		Línea 19:

	==Diagnostic Evaluation==		==Diagnostic Evaluation==
			*Establish possible exposure in endemic areas
			*Serology (peripheral blood) - draw at night due to periodicity of filiariae
			*Tests for ''W. bancrofti''
			**PCR
			**Antigen detection
			**Ultrasound may occasionally show movement of adult filiariae

	==Management==		==Management==

Mholtz at 09:20, 6 September 2015

2015-09-06T09:20:13Z

← Revisión anterior		Revisión del 09:20 6 sep 2015
Línea 2:		Línea 2:
	*Also known as elephantiasis		*Also known as elephantiasis
	*Causative agents:		*Causative agents:
	**Wuchereria bancrofti		**''Wuchereria bancrofti''
	**Brugia malayi		**''Brugia malayi''
	**Brugia timori		**''Brugia timori''
			*Larvae migrate to lymphatic vessels and mature into adults

	==Clinical Features==		==Clinical Features==
	*Larvae migrate to lymphatic vessels and mature into adults
	*Massive peripheral edema with thickening of overlying skin particularly in lower extremities and genitalia		*Massive peripheral edema with thickening of overlying skin particularly in lower extremities and genitalia
	*Recurrent [[cellulitis]] is common		*Recurrent [[cellulitis]] is common
Línea 13:		Línea 13:
	==Differential Diagnosis==		==Differential Diagnosis==

	==~~Workup~~==
			==Diagnostic Evaluation==


	==Management==		==Management==
Línea 26:		Línea 28:

	==Disposition==		==Disposition==


	==See Also==		==See Also==
Línea 34:		Línea 37:
	==External Links==		==External Links==

	==~~Sources~~==
			==References==
	<references/>		<references/>

	[[Category:ID]]		[[Category:ID]]
	[[Category:TropMed]]		[[Category:TropMed]]