https://wikem.org/w/index.php?action=history&feed=atom&title=Lofexidine 2026-04-17T12:07:16Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Lofexidine&diff=189455&oldid=prev 2018-08-12T18:32:39Z

<p>Created page with &quot;==Administration== *Type: Central alpha&lt;sub&gt;2&lt;/sub&gt; adrenergic agonist, opioid withdrawal *Dosage Forms: 0.18 mg tablets *Routes of Administration: oral *Common Trade Names: L...&quot;</p> <p><b>Página nueva</b></p><div>==Administration==<br /> *Type: Central alpha&lt;sub&gt;2&lt;/sub&gt; adrenergic agonist, opioid withdrawal<br /> *Dosage Forms: 0.18 mg tablets<br /> *Routes of Administration: oral<br /> *Common Trade Names: Lucemyra<br /> <br /> ==Adult Dosing==<br /> ===Opioid Withdrawal===<br /> 0.54 mg PO q6h during peak withdrawal symptoms<br /> *Do not exceed 2.88 mg (16 tablets) per day<br /> *Do not exceed 0.72 mg (4 tablets) in a single dose&lt;br /&gt;<br /> May be continued for up to 14 days, gradually reduce dose over 2-4 days to mitigate Lofexidine withdrawal symptoms<br /> <br /> ==Special Populations==<br /> ===[[Drug pregnancy categories|Pregnancy Rating]]===<br /> *Limited information<br /> <br /> ===Lactation risk===<br /> *Unknown<br /> <br /> ===Renal Dosing===<br /> *eGFR 30 to 90: 0.36 mg q6h<br /> *eGFR &lt;30: 0.18 mg q6h<br /> *ESRD/HD: 0.18 mg q6h, minimally dialyzable<br /> <br /> ===Hepatic Dosing===<br /> *Mild impairment (Child-Pugh class A): no adjustment<br /> *Moderate impairment (Child-Pugh class B): 0.36 mg q6h<br /> *Severe impairment (Child-Pugh class C): 0.18 mg q6h<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug<br /> *Caution with prior history or family history of long QT syndrome<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *[[Torsades de pointes]]<br /> <br /> ===Common===<br /> *Orthostatic hypotension<br /> *Bradycardia<br /> *Dizziness<br /> *Somnolence<br /> *Sedation<br /> *Insomnia<br /> *Dry mouth<br /> <br /> ==Pharmacology==<br /> *Half-life: 11 to 13 hours (first dose), 17 to 22 hours (steady state)<br /> *Metabolism: First pass associated with gut absorption, hepatic via CYP2D6 (primary), CYP1A2, and CYP2C19<br /> *Excretion: Urine (94%), Feces (1%)<br /> <br /> ==Mechanism of Action==<br /> *Centrally acting alpha2 agonist that decreases sympathetic output and symptoms of withdrawal<br /> *Thought to have less anti-hypertensive activity than Clonidine<br /> <br /> ==Comments==<br /> *Patient's may respond to lower opioid doses increasing risk of overdose<br /> *0.18 mg tablet = $24.83<br /> <br /> ==See Also==<br /> [[Opioid withdrawal]]<br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Pharmacology]]</div>

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