Levocarnitine - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:58:34Z

Switch SMW query from broadtable to table format for better layout with TOC

← Revisión anterior		Revisión del 21:58 20 mar 2026
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	\|?Has Route=Route		\|?Has Route=Route
	\|?Has Population=Population		\|?Has Population=Population
	\|format=~~broadtable~~		\|format=table
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Danbot: Add Indications by Condition SMW query table

2026-03-20T17:45:43Z

Add Indications by Condition SMW query table

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 *Increases valproate metabolism
 ==Comments==
 ==See Also==

ClaireLewis: /* References */

2019-09-22T22:53:19Z

References

← Revisión anterior		Revisión del 22:53 22 sep 2019
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	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:FEN]]
			[[Category:Toxicology]]

Bmurray990: /* Administration */

2019-01-26T21:26:39Z

Administration

← Revisión anterior		Revisión del 21:26 26 ene 2019
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	==Administration==		==Administration==
	*Type: amino-acid derivative, [[Antidote]]		*Type: amino-acid derivative, [[Antidote]]
	*Dosage Forms: IV~~, tablet, oral solution~~		*Dosage Forms: Capsule 250mg, 330mg; Solution (PO) 1g/10mL; Solution (IV) 200mg/mL
	*Routes of Administration: IV, oral		*Routes of Administration: IV, oral
	*Common Trade Names:		*Common Trade Names: Carnitor

	==Adult Dosing==		==Adult Dosing==

Bmurray990: /* Pharmacology */

2019-01-26T21:24:48Z

Pharmacology

← Revisión anterior		Revisión del 21:24 26 ene 2019
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	==Pharmacology==		==Pharmacology==
	*Half-life: 17.4h		*Half-life: 17.4h
	*Metabolism:		*Metabolism: Hepatic
	*Excretion: Mostly renal		*Excretion: Mostly renal

Mholtz: Text replacement - "prn" to "PRN"

2017-07-07T08:28:13Z

Text replacement - "prn" to "PRN"

← Revisión anterior		Revisión del 08:28 7 jul 2017
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	*Primary carnitine deficiency: 990mg tablet or 1g solution PO 1-3 times per day		*Primary carnitine deficiency: 990mg tablet or 1g solution PO 1-3 times per day
	*Carnitine deficiency due to inborn error of metabolism		*Carnitine deficiency due to inborn error of metabolism
	**Initial: 50 mg/kg (max 300mg) IV bolus, repeat daily ~~prn~~		**Initial: 50 mg/kg (max 300mg) IV bolus, repeat daily PRN
	**Severe metabolic crisis: 50 mg/kg IV (max 300mg) IV bolus, then repeat 50mg/kg IV over 24h in divided doses. Repeat 50mg/kg IV daily ~~prn~~.		**Severe metabolic crisis: 50 mg/kg IV (max 300mg) IV bolus, then repeat 50mg/kg IV over 24h in divided doses. Repeat 50mg/kg IV daily PRN.
	**990mg tablet or 1g solution PO 1-3 times per day		**990mg tablet or 1g solution PO 1-3 times per day
	*Carnitine deficiency due to ESRD: 10 to 20 mg/kg (dry weight) after HD, subsequent dosing determent by pre-HD levels of levocarnitine		*Carnitine deficiency due to ESRD: 10 to 20 mg/kg (dry weight) after HD, subsequent dosing determent by pre-HD levels of levocarnitine

ClaireLewis: Created page with "==Administration== Type: amino-acid derivative, Antidote Dosage Forms: IV, tablet, oral solution Routes of Administration: IV, oral Common Trade Names: ==Adult Dosin..."

2016-10-19T17:01:27Z

Created page with "==Administration== *Type: amino-acid derivative, Antidote *Dosage Forms: IV, tablet, oral solution *Routes of Administration: IV, oral *Common Trade Names: ==Adult Dosin..."

Página nueva

==Administration==
*Type: amino-acid derivative, [[Antidote]]
*Dosage Forms: IV, tablet, oral solution
*Routes of Administration: IV, oral
*Common Trade Names:

==Adult Dosing==
*[[Valproic acid toxicity]]: 100mg/kg IV bolus, followed by 50mg/kg Q8h or alternatively 50mg/kg/day IV in 3 divided doses
*Primary carnitine deficiency: 990mg tablet or 1g solution PO 1-3 times per day
*Carnitine deficiency due to inborn error of metabolism
**Initial: 50 mg/kg (max 300mg) IV bolus, repeat daily prn
**Severe metabolic crisis: 50 mg/kg IV (max 300mg) IV bolus, then repeat 50mg/kg IV over 24h in divided doses. Repeat 50mg/kg IV daily prn.
**990mg tablet or 1g solution PO 1-3 times per day
*Carnitine deficiency due to ESRD: 10 to 20 mg/kg (dry weight) after HD, subsequent dosing determent by pre-HD levels of levocarnitine
==Pediatric Dosing==
*IV dosing: same as adult dosing
*PO dosing: 50 mg/kg PO

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Renal dosing: dosing not established, may be more prone to accumulation of toxic metabolites
*Hepatic dosing: no adjustment

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Seizure
===Common===
*Nausea/vomiting, diarrhea, stomach cramps

==Pharmacology==
*Half-life: 17.4h
*Metabolism:
*Excretion: Mostly renal

==Mechanism of Action==
*Amino-acid found normally in humans: facilitates entry of long-chain fatty acids into cellular mitochondria
*Increases valproate metabolism
==Comments==

==See Also==
*[[Antidotes]]
*[[Valproic acid toxicity]]
*[[Inborn errors of metabolism]]
==References==
<references/>
[[Category:Pharmacology]]