Ketofol - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:57:59Z

Switch SMW query from broadtable to table format for better layout with TOC

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	\|?Has Route=Route		\|?Has Route=Route
	\|?Has Population=Population		\|?Has Population=Population
	\|format=~~broadtable~~		\|format=table
	\|headers=plain		\|headers=plain
	\|mainlabel=-		\|mainlabel=-

Danbot: Add MedicationDose SMW query table for dynamic indications by condition

2026-03-20T20:36:40Z

Add MedicationDose SMW query table for dynamic indications by condition

@@ Línea 67: / Línea 67: @@
 **50% ketamine mixed with 50% propofol in same syringe
 **Pretreatment with 1/2 dose ketamine, followed by propofol
 ==See Also==

Elcatracho: /* See Also */

2021-07-08T20:09:56Z

Elcatracho: /* Serious */

2021-07-08T19:58:16Z

Serious

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	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
	*Laryngospasm		*[[Laryngospasm]]
	*Apnea or respiratory depression		*Apnea or respiratory depression
	*Hypersalivation (rare)		*Hypersalivation (rare)

Elcatracho: /* Common */

2021-07-08T19:57:48Z

Common

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	===Common===		===Common===
	*Nausea/vomiting		*Nausea/vomiting
	*~~Emergency~~ reaction/agitation		*Emergence reaction/agitation
	*Muscular hypertonicity, random movements, clonus, hiccuping		*Muscular hypertonicity, random movements, clonus, hiccuping
	*Rash		*Rash

ClaireLewis at 22:33, 22 September 2019

2019-09-22T22:33:02Z

← Revisión anterior		Revisión del 22:33 22 sep 2019
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	==General==		==General==
	*Type: [[Sedative agents]]		*Type: [[Sedative agents]], 1:1 mixture of [[ketamine]] and [[propofol]]
	*Dosage Forms:		*Dosage Forms:
	*Common Trade Names:		*Common Trade Names:
Línea 22:		Línea 22:
	==Contraindications==		==Contraindications==
	*Allergy to class/drug		*Allergy to class/drug
			*<3 month old (ketamine)
			*Known or suspected schizophrenia, even if currently stable or controlled with medications (ketamine)
			*Allergy to soy or eggs (propofol)
			*Hypotension (propofol)
			*Aortic stenosis (propofol)

	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
			*Laryngospasm
			*Apnea or respiratory depression
			*Hypersalivation (rare)
			*Raised ICP (CPP only compromised in patients with preexisting intracranial hypertension and obstructed CSF flow)<ref>Filanovsky, Y., Philip Miller et al. Myth: Ketamine should not be used as an induction agent for intubation in patients with head injury. CJEM 2010;12(2):154-7. [http://cjem-online.ca/sites/cjem-online.ca/files/pg154_0.pdf PDF]</ref> Meta-analysis also suggests that Ketamine does not increase ICP and provides favorable hemodynamics.<ref>Wang X et al. Ketamine does not increase intracranial pressure compared with opioids: meta-analysis of randomized controlled trials. J Anesth 2014. PubMed ID: 24859931</ref>
			*Respiratory depression
			*Transient hypotension
			*Pain at injection site (inject lidocaine 20-40mg IV and fentanyl 50 mcg IV first)
			*[[Hypertriglyceridemia]] - check TG levels in ICU setting
			*Cardiac arrest (patients with significant cardiac disease receiving propofol for induction at highest risk)

	===Common===		===Common===
			*Nausea/vomiting
			*Emergency reaction/agitation
			*Muscular hypertonicity, random movements, clonus, hiccuping
			*Rash

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life:
	*Metabolism:		*Metabolism: hepatic
	*Excretion:		*Excretion: urine
	*Mechanism of Action:		*Mechanism of Action: ketamine- NMDA receptor antagonist; propofol- GABA agonist

	==Preparation and Administration==		==Preparation and Administration==

Neil.m.young: Text replacement - "5 mg" to "5mg"

2016-07-21T07:51:16Z

Text replacement - "5 mg" to "5mg"

← Revisión anterior		Revisión del 07:51 21 jul 2016
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	==Adult Dosing==		==Adult Dosing==
	*Starting dose: 0.~~5 mg~~/kg followed by another 0.~~5 mg~~/kg after 30-60 seconds		*Starting dose: 0.5mg/kg followed by another 0.5mg/kg after 30-60 seconds
	*Maintenance: 0.~~25 mg~~/kg as needed		*Maintenance: 0.25mg/kg as needed

	==Pediatric Dosing==		==Pediatric Dosing==

Neil.m.young: Text replacement - "0 mg" to "0mg"

2016-07-19T17:56:29Z

Text replacement - "0 mg" to "0mg"

← Revisión anterior		Revisión del 17:56 19 jul 2016
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	==Preparation and Administration==		==Preparation and Administration==
	*'''[[Ketamine]]'''		*'''[[Ketamine]]'''
	**Comes in a ~~50 mg~~/mL concentration		**Comes in a 50mg/mL concentration
	**take a 10 mL saline flush and empty 2 mL and draw up 2 mL of ketamine		**take a 10 mL saline flush and empty 2 mL and draw up 2 mL of ketamine
	***~~100 mg~~ of ketamine in flush		***100mg of ketamine in flush
	*'''[[Propofol]]'''		*'''[[Propofol]]'''
	**Comes in a standard ~~10 mg~~/mL concentration.		**Comes in a standard 10mg/mL concentration.
	***fill a different 10 mL syringe with this you have ~~100 mg~~ of propofol		***fill a different 10 mL syringe with this you have 100mg of propofol
	*If you mix the two in a new 20 or 30 mL syringe you get ~~100 mg~~ ketamine + ~~100 mg~~ propofol = ~~200 mg~~ total.		*If you mix the two in a new 20 or 30 mL syringe you get 100mg ketamine + 100mg propofol = 200mg total.
	**Every one mL has ~~10 mg~~ of ketofol		**Every one mL has 10mg of ketofol

	==Comments==		==Comments==

Neil.m.young: Text replacement - "* " to "*"

2016-07-04T16:45:05Z

Text replacement - "* " to "*"

← Revisión anterior		Revisión del 16:45 4 jul 2016
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	==Comments==		==Comments==
	* 2 definitions		*2 definitions
	**50% ketamine mixed with 50% propofol in same syringe		**50% ketamine mixed with 50% propofol in same syringe
	**Pretreatment with 1/2 dose ketamine, followed by propofol		**Pretreatment with 1/2 dose ketamine, followed by propofol

Ostermayer: Text replacement - "Category:Drugs" to "Category:Pharmacology"

2016-03-22T15:54:24Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"

← Revisión anterior		Revisión del 15:54 22 mar 2016
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	==References==		==References==
	<references/>		<references/>
	[[Category:~~Drugs~~]]		[[Category:Pharmacology]]

← Revisión anterior		Revisión del 20:09 8 jul 2021
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	*[[Sedation (Main)]]		*[[Sedation (Main)]]
	*[[Procedural Sedation]]		*[[Procedural Sedation]]

			==External Links==
			*[https://www.aliem.com/ketofol-game-changer-procedural-sedation/ AliEM: Ketofol: Is this the “Game Changer” of Procedural Sedation and Analgesia?]

	==References==		==References==
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]