Isotretinoin - Revision history

ClaireLewis at 05:31, 21 April 2021

2021-04-21T05:31:33Z

← Revisión anterior		Revisión del 05:31 21 abr 2021
Línea 2:		Línea 2:
	*Type:		*Type:
	*Dosage Forms:		*Dosage Forms:
	*Routes of Administration:		*Routes of Administration: IV, PO
	*Common Trade Names: Accutane		*Common Trade Names: Accutane

	==Adult Dosing==		==Adult Dosing==
			*Acne: 0.25 mg/kg twice daily x 1 month, then 0.5 mg/kg twice daily as tolerated; continue until a total cumulative dose of 120 to 150 mg/kg is reached
			*Cutaneous T cell lymphoma/other cancers IV doses vary

	==Pediatric Dosing==		==Pediatric Dosing==
			*Used for acne, neuroblastoma

	==Special Populations==		==Special Populations==
	===[[Drug pregnancy categories\|Pregnancy Rating]]===		===[[Drug pregnancy categories\|Pregnancy Rating]]===
	*		*X

	===Lactation risk===		===Lactation risk===
	*		*unknown

	===Renal Dosing===		===Renal Dosing===
	*~~Adult:~~		*No adjustment
	*Pediatric:

	===Hepatic Dosing===		===Hepatic Dosing===
	*~~Adult:~~		*No adjustment
	*Pediatric:

	==Contraindications==		==Contraindications==
	*Allergy to class/drug		*Allergy to class/drug
			*Pregnancy

	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
			*Hearing impairment
			*Bone mineral density loss leading to fractures/delayed fracture healing, skeletal hyperostosis/premature epiphyseal closure
			*Erythema multiforme, SJS, TEN
			*Agranulocytosis, neutropenia
			*Hepatitis
			*Hypersensitivity reactions (anaphylaxis, allergic vasculitis)
			*IBD, ileitis
			*Rhabdomyolysis
			*Visual impairment, corneal opacities
			*Pancreatitis
			*Pseudotumor cerebri
			*Psychiatric effects (depressed mood/suicidal ideation, psychosis)
			*[[ATRA syndrome]]

	===Common===		===Common===
			*Increased triglycerides, decreased HDL, increased CPK
			*Increased LFTs
			*Arthralgia, back pain
			*Decreased bone mineral density
			*Photosensitivity

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 5-38h
	*Metabolism:		*Metabolism: Hepatic via CYP2B6, 2C8, 2C9, 3A4
	*Excretion:		*Excretion: Urine and feces

	==Mechanism of Action==		==Mechanism of Action==
			*Induces apoptosis in certain cells, including those of the sebaceous glands

	==Comments==		==Comments==

Elcatracho: /* See Also */

2021-02-27T00:05:41Z

Elcatracho: /* Administration */

2021-02-27T00:05:15Z

Administration

← Revisión anterior		Revisión del 00:05 27 feb 2021
Línea 3:		Línea 3:
	*Dosage Forms:		*Dosage Forms:
	*Routes of Administration:		*Routes of Administration:
	*Common Trade Names:		*Common Trade Names: Accutane

	==Adult Dosing==		==Adult Dosing==

Elcatracho: Created page with "==Administration== Type: Dosage Forms: Routes of Administration: Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== ===Drug pregnan..."

2021-02-27T00:04:37Z

Created page with "==Administration== *Type: *Dosage Forms: *Routes of Administration: *Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== ===Drug pregnan..."

Página nueva

==Administration==
*Type:
*Dosage Forms:
*Routes of Administration:
*Common Trade Names:

==Adult Dosing==

==Pediatric Dosing==

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*

===Lactation risk===
*

===Renal Dosing===
*Adult:
*Pediatric:

===Hepatic Dosing===
*Adult:
*Pediatric:

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===

===Common===

==Pharmacology==
*Half-life:
*Metabolism:
*Excretion:

==Mechanism of Action==

==Comments==

==See Also==

==References==
<references/>

[[Category:Pharmacology]]

← Revisión anterior		Revisión del 00:05 27 feb 2021
Línea 48:		Línea 48:

	==See Also==		==See Also==
			*[[Acne]]
			*[[Vitamin A toxicity]]

	==References==		==References==

Isotretinoin - Revision history

ClaireLewis at 05:31, 21 April 2021

Elcatracho: /* See Also */

Elcatracho: /* Administration */

Elcatracho: Created page with "==Administration== *Type: *Dosage Forms: *Routes of Administration: *Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== ===Drug pregnan..."

Elcatracho: Created page with "==Administration== Type: Dosage Forms: Routes of Administration: Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== ===Drug pregnan..."