IgG4 related disease - Revision history

Rossdonaldson1: /* References */

2022-09-07T18:07:42Z

References

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	<references/>		<references/>

	[Category:Rheumatology]]		[[Category:Rheumatology]]

Rossdonaldson1 at 18:07, 7 September 2022

2022-09-07T18:07:01Z

← Revisión anterior		Revisión del 18:07 7 sep 2022
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	==Clinical Features==		==Clinical Features==
	*No specific symptoms as it is dependent on which organs are affected		*No specific symptoms as it is dependent on which organs are affected
	*Autoimmune pancreatitis is the most common presentation of IgG4-RD and can be mistaken for malignancy		*Autoimmune pancreatitis is the most common presentation of IgG4-RD and can be mistaken for malignancy<ref>Nambiar S, Oliver TI. IgG4 Related Disease. [Updated 2022 May 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499825/</ref>
	*Patients do not typically experience generalized symptoms such as fevers or night sweats		*Patients do not typically experience generalized symptoms such as fevers or night sweats

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	==Evaluation==		==Evaluation==
			*Typically, diagnosis not made in the ED

			===Outpatient Workup===
	*Tissue biopsy with IgG stain is required for diagnosis		*Tissue biopsy with IgG stain is required for diagnosis
	*Serum IgG4 levels are usually elevated and helpful for diagnosis and also helpful for serial monitoring		*Serum IgG4 levels are usually elevated and helpful for diagnosis and also helpful for serial monitoring
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	*Further immunosuppression may be warranted based on response to prednisone		*Further immunosuppression may be warranted based on response to prednisone
	*Consultation with a rheumatologist is usually necessary		*Consultation with a rheumatologist is usually necessary

			==Disposition==

			==See Also==

			==External Links==

	==References==		==References==
	<references/>		<references/>

	Nambiar S, Oliver TI. IgG4 Related Disease. [Updated 2022 May 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499825/		[Category:Rheumatology]]

	[[Category:Rheumatology]]

Kfarzam: /* References */

2022-08-18T06:55:36Z

References

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	==References==		==References==
	<references/>		<references/>

			Nambiar S, Oliver TI. IgG4 Related Disease. [Updated 2022 May 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499825/

	[[Category:Rheumatology]]		[[Category:Rheumatology]]

Kfarzam: /* Differential Diagnosis */

2022-08-18T06:54:45Z

Differential Diagnosis

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	==Differential Diagnosis==		==Differential Diagnosis==
	{{Pancreatic cancer}}		*Pancreatic cancer
	{{Sjogren's syndrome}}		*Sjogren's syndrome
	{{Primary sclerosing cholangitis}}		*Primary sclerosing cholangitis
	{{Retroperitoneal fibrosis}}		*Retroperitoneal fibrosis
	{{Castleman disease}}		*Castleman disease

	==Evaluation==		==Evaluation==

Kfarzam: /* Background */

2022-08-18T06:53:30Z

Background

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	==Background==		==Background==
	*IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory illness of unknown etiology.		*IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory illness of unknown etiology
			*It's a multi organ disease that most commonly affects the pancreas, kidneys, retroperitoneum, salivary glands and orbits

			==Clinical Features==
			*No specific symptoms as it is dependent on which organs are affected
			*Autoimmune pancreatitis is the most common presentation of IgG4-RD and can be mistaken for malignancy
			*Patients do not typically experience generalized symptoms such as fevers or night sweats

			==Differential Diagnosis==
			{{Pancreatic cancer}}
			{{Sjogren's syndrome}}
			{{Primary sclerosing cholangitis}}
			{{Retroperitoneal fibrosis}}
			{{Castleman disease}}

			==Evaluation==
			*Tissue biopsy with IgG stain is required for diagnosis
			*Serum IgG4 levels are usually elevated and helpful for diagnosis and also helpful for serial monitoring
			*C3 and C4 complement levels may be decreased
			*Total serum IgG levels may also be elevated

			==Management==
			*Prednisone at higher doses is the current standard treatment
			*Further immunosuppression may be warranted based on response to prednisone
			*Consultation with a rheumatologist is usually necessary

			==References==
			<references/>

			[[Category:Rheumatology]]

Kfarzam: new page - plan to add/edit

2022-08-17T04:00:44Z

new page - plan to add/edit

Página nueva

==Background==
*IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory illness of unknown etiology.