ITP in Pregnancy - Revision history

Rossdonaldson1: /* Clinical Features */

2024-01-31T18:32:57Z

Clinical Features

← Revisión anterior		Revisión del 18:32 31 ene 2024
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	==Clinical Features==		==Clinical Features==
			[[File:Purpura.jpg\|thumb\|Petechiae in a patient with ITP.]]
			[[File:Petechia on the tongue.jpg\|thumb\|Petechiae on the tongue in a patient with ITP.]]
			[[File:Petechia lower leg2.jpg\|thumb\|Petechiae on the lower leg in a patient with ITP.]]
			[[File:PMC4192833 TODENTJ-8-164 F1.png\|thumb\|Unprovoked gingival bleeding as a presenting symptom in ITP.]]
	*[[Thrombocytopenia]] during pregnancy		*[[Thrombocytopenia]] during pregnancy
	**[[Petechiae]]		**[[Petechiae]]

Rossdonaldson1 at 22:34, 24 January 2024

2024-01-24T22:34:06Z

← Revisión anterior		Revisión del 22:34 24 ene 2024
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	''See also [[ITP]] main page''		''See also [[ITP]] main page or [[Immune thrombocytopenic purpura (peds)]] for pediatric patients.''
	==Background==		==Background==
	*Marked diff between maternal and fetal platelet counts		*Marked diff between maternal and fetal platelet counts

ClaireLewis: /* Clinical Features */

2019-10-01T01:22:20Z

Clinical Features

← Revisión anterior		Revisión del 01:22 1 oct 2019
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	**[[Epistaxis]]		**[[Epistaxis]]
	**[[Gingival bleeding]]		**[[Gingival bleeding]]
	*[[Vaginal Bleeding]]		**[[Vaginal Bleeding]]
	*[[GI bleeding]]		**[[GI bleeding]]
	*[[Intracranial hemorrhage]]		**[[Intracranial hemorrhage]]

	==Differential Diagnosis==		==Differential Diagnosis==

ClaireLewis at 01:22, 1 October 2019

2019-10-01T01:22:01Z

← Revisión anterior		Revisión del 01:22 1 oct 2019
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			''See also [[ITP]] main page''
	==Background==		==Background==
	*Marked diff between maternal and fetal platelet counts		*Marked diff between maternal and fetal platelet counts
Línea 6:		Línea 7:

	==Clinical Features==		==Clinical Features==
	*~~Low platelets~~ during pregnancy		*[[Thrombocytopenia]] during pregnancy
			**[[Petechiae]]
			**[[Epistaxis]]
			**[[Gingival bleeding]]
			*[[Vaginal Bleeding]]
			*[[GI bleeding]]
			*[[Intracranial hemorrhage]]

	==Differential Diagnosis==		==Differential Diagnosis==
	*preg induced hypertension		{{Thrombocytopenia}}
	*HELLP
	*microangiopathic hemolytic anemia
	*hereditary
	*thrombocytopenias

	==Evaluation==		==Evaluation==
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	==Management==		==Management==
	*~~Most medications are teratogenic~~ or ~~worsens gestational diabetes (~~prednisone~~) so use iv IG mostly~~		*Balance risk of thrombocytopenia (for mother and fetus/baby) vs potential teratogenesis from therapy
	*~~baby~~ with v low risk of ICH- but higher of normal baby		*Treatment indicated if<ref>Stavrou E, Mccrae KR. Immune thrombocytopenia in pregnancy. Hematol Oncol Clin North Am. 2009;23(6):1299-316.</ref>:
	*~~risk~~ of ICH ~~not change with cesarean~~		**Platelets <10,000
	*if baby ~~with~~ platelets <30k~~, try iv ig~~ and or [[prednisone]]		**Platelets <30,000 and bleeding or in 2nd or 3rd trimester
	*~~exchange xfusion only if severe.~~		*Risk of [[prednisone]] or [[IVIG]] outweighed by benefits in above situations<ref>https://www.ouh.nhs.uk/patient-guide/leaflets/files/13880Pitp.pdf</ref>
	*no problem for breast feeding.		*Infant has slightly increased risk of [[ICH]] with v low risk of ICH- but higher of normal baby
			**role of cesarean in preventing ICH controversial
			*If baby has platelets <30k; [[IVIG]] and or [[prednisone]]
			*No contraindication to breastfeeding.

	==See Also==		==See Also==

Rossdonaldson1: Text replacement - " prednisone" to " prednisone"

2016-08-03T23:52:48Z

Text replacement - " prednisone" to " prednisone"

← Revisión anterior		Revisión del 23:52 3 ago 2016
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	*baby with v low risk of ICH- but higher of normal baby		*baby with v low risk of ICH- but higher of normal baby
	*risk of ICH not change with cesarean		*risk of ICH not change with cesarean
	*if baby with platelets <30k, try iv ig and or prednisone		*if baby with platelets <30k, try iv ig and or [[prednisone]]
	*exchange xfusion only if severe.		*exchange xfusion only if severe.
	*no problem for breast feeding.		*no problem for breast feeding.

Rossdonaldson1: Text replacement - "HTN" to "hypertension"

2016-07-31T13:45:57Z

Text replacement - "HTN" to "hypertension"

← Revisión anterior		Revisión del 13:45 31 jul 2016
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	==Differential Diagnosis==		==Differential Diagnosis==
	*preg induced ~~HTN~~		*preg induced hypertension
	*HELLP		*HELLP
	*microangiopathic hemolytic anemia		*microangiopathic hemolytic anemia

Neil.m.young: Text replacement - "==Diagnosis==" to "==Evaluation=="

2016-07-24T01:11:04Z

Text replacement - "==Diagnosis==" to "==Evaluation=="

← Revisión anterior		Revisión del 01:11 24 jul 2016
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	*thrombocytopenias		*thrombocytopenias

	==~~Diagnosis~~==		==Evaluation==
	*Usually mild thrombocytopenia (>70k)		*Usually mild thrombocytopenia (>70k)
	**Platelet count normalizes after delivery		**Platelet count normalizes after delivery

Neil.m.young: Text replacement - "==Treatment==" to "==Management=="

2016-07-08T16:37:01Z

Text replacement - "==Treatment==" to "==Management=="

← Revisión anterior		Revisión del 16:37 8 jul 2016
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	**Platelet count normalizes after delivery		**Platelet count normalizes after delivery

	==~~Treatment~~==		==Management==
	*Most medications are teratogenic or worsens gestational diabetes (prednisone) so use iv IG mostly		*Most medications are teratogenic or worsens gestational diabetes (prednisone) so use iv IG mostly
	*baby with v low risk of ICH- but higher of normal baby		*baby with v low risk of ICH- but higher of normal baby

Neil.m.young: Text replacement - "* " to "*"

2016-07-05T23:07:53Z

Text replacement - "* " to "*"

← Revisión anterior		Revisión del 23:07 5 jul 2016
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	==Treatment==		==Treatment==
	*Most medications are teratogenic or worsens gestational diabetes (prednisone) so use iv IG mostly		*Most medications are teratogenic or worsens gestational diabetes (prednisone) so use iv IG mostly
	* baby with v low risk of ICH- but higher of normal baby		*baby with v low risk of ICH- but higher of normal baby
	* risk of ICH not change with cesarean		*risk of ICH not change with cesarean
	* if baby with platelets <30k, try iv ig and or prednisone		*if baby with platelets <30k, try iv ig and or prednisone
	* exchange xfusion only if severe.		*exchange xfusion only if severe.
	* no problem for breast feeding.		*no problem for breast feeding.

	==See Also==		==See Also==

Neil.m.young: Text replacement - "==Source==" to "==References== "

2016-06-27T18:14:31Z

Text replacement - "==Source==" to "==References== <references/>"

← Revisión anterior		Revisión del 18:14 27 jun 2016
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	*[[Pregnancy (Main)]]		*[[Pregnancy (Main)]]

	==~~Source~~==		==References==
			<references/>

	[[Category:Heme/Onc]]		[[Category:Heme/Onc]]
	[[Category:OBGYN]]		[[Category:OBGYN]]