Hypertonic saline - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:57:03Z

Switch SMW query from broadtable to table format for better layout with TOC

← Revisión anterior		Revisión del 21:57 20 mar 2026
Línea 71:		Línea 71:
	\|?Has Route=Route		\|?Has Route=Route
	\|?Has Population=Population		\|?Has Population=Population
	\|format=~~broadtable~~		\|format=table
	\|headers=plain		\|headers=plain
	\|mainlabel=-		\|mainlabel=-

Danbot: Add Indications by Condition SMW query table

2026-03-20T17:45:58Z

Add Indications by Condition SMW query table

← Revisión anterior		Revisión del 17:45 20 mar 2026
Línea 60:		Línea 60:

	==Comments==		==Comments==


			==Indications by Condition==
			''The following table is automatically generated from disease/condition pages across WikEM.''

			{{#ask:[[Has DrugName::Hypertonic saline]]
			\|?Has Indication=Indication
			\|?Has Dose=Dose
			\|?Has Context=Context
			\|?Has Route=Route
			\|?Has Population=Population
			\|format=broadtable
			\|headers=plain
			\|mainlabel=-
			\|sort=Has Indication
			\|limit=50
			}}

	==See Also==		==See Also==

ClaireLewis at 20:28, 22 September 2019

2019-09-22T20:28:07Z

← Revisión anterior		Revisión del 20:28 22 sep 2019
Línea 8:		Línea 8:

	==Adult Dosing==		==Adult Dosing==
	===Symptomatic Hyponatremia===		===Symptomatic [[Hyponatremia]]===
	*Bolus 100-250mL 3% NS 100cc bolus over 10min; repeat after 10min x1 if no improvement		*Bolus 100-250mL 3% NS 100cc bolus over 10min; repeat after 10min x1 if no improvement
	===Elevated ICP===		===[[Elevated ICP]]===
	*Most studies used 250 mL bolus of 7.5% HTS with dextran<ref>Holmes, J. Therapeutic uses of Hypertonic Saline in the Critically Ill Emergency Department Patient. EB Medicine 2013</ref>		*Most studies used 250 mL bolus of 7.5% HTS with dextran<ref>Holmes, J. Therapeutic uses of Hypertonic Saline in the Critically Ill Emergency Department Patient. EB Medicine 2013</ref>
	*Initial 250mL bolus of 3% will reduce ICP and can be delivered through a peripheral line		*Initial 250mL bolus of 3% will reduce ICP and can be delivered through a peripheral line
Línea 16:		Línea 16:

	==Pediatric Dosing==		==Pediatric Dosing==
	*Symptomatic hyponatremia: 2mL/kg of 3% over 10-60 minutes, repeat of up to 3 times		*Symptomatic [[hyponatremia]]: 2mL/kg of 3% over 10-60 minutes, repeat of up to 3 times
	*Elevated ICP		*[[Elevated ICP]]
	**3% NS: 3-10 mL/kg over 10-60 minutes<ref>Kochanek PM, Carney N, Adelson PD, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents--second edition. Pediatr Crit Care Med. 2012;13 Suppl 1:S1-82.</ref>		**3% NS: 3-10 mL/kg over 10-60 minutes<ref>Kochanek PM, Carney N, Adelson PD, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents--second edition. Pediatr Crit Care Med. 2012;13 Suppl 1:S1-82.</ref>
	**Titrate to serum Na 145-150		**Titrate to serum Na 145-150

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]:		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C
	*[[Lactation risk categories\|Lactation risk]]:		*[[Lactation risk categories\|Lactation risk]]: Infant risk minimal
	===Renal Dosing===		===Renal Dosing===
	*Adult:		*Adult:
Línea 69:		Línea 69:
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:FEN]]

Kxl328: /* Elevated ICP */

2019-07-07T12:30:57Z

Elevated ICP

← Revisión anterior		Revisión del 12:30 7 jul 2019
Línea 11:		Línea 11:
	*Bolus 100-250mL 3% NS 100cc bolus over 10min; repeat after 10min x1 if no improvement		*Bolus 100-250mL 3% NS 100cc bolus over 10min; repeat after 10min x1 if no improvement
	===Elevated ICP===		===Elevated ICP===
	*Most studies used 250 mL bolus of 7.5% NS with dextran<ref>Holmes, J. Therapeutic uses of Hypertonic Saline in the Critically Ill Emergency Department Patient. EB Medicine 2013</ref>		*Most studies used 250 mL bolus of 7.5% HTS with dextran<ref>Holmes, J. Therapeutic uses of Hypertonic Saline in the Critically Ill Emergency Department Patient. EB Medicine 2013</ref>
	*Initial 250mL bolus of 3% will reduce ICP and can be delivered through a peripheral line		*Initial 250mL bolus of 3% will reduce ICP and can be delivered through a peripheral line
	*Target Na 145-155 meq/dL		*Target Na 145-155 meq/dL

Ostermayer: Text replacement - "Hypotension " to "Hypotension"

2017-03-10T13:41:56Z

Text replacement - "Hypotension " to "Hypotension"

← Revisión anterior		Revisión del 13:41 10 mar 2017
Línea 39:		Línea 39:
	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
	*Hypotension (infusion rate-related)		*[[Hypotension]](infusion rate-related)
	*Metabolic acidosis		*Metabolic acidosis
	*Hypernatraemia		*Hypernatraemia

ClaireLewis: Created page with "==Administration== Type: Osmotherapy, electrolyte/IVF Dosage Forms: 3% (513mEq/L) 5% (856mEq/L) **23.4% (4000mEq/L) *Nebulized (as adjunct for bronchiolitis, cyst..."

2016-10-05T06:51:31Z

Created page with "==Administration== *Type: Osmotherapy, electrolyte/IVF *Dosage Forms: **3% (513mEq/L) **5% (856mEq/L) **23.4% (4000mEq/L) *Nebulized (as adjunct for bronchiolitis, cyst..."

Página nueva

==Administration==
*Type: Osmotherapy, electrolyte/IVF
*Dosage Forms:
**3% (513mEq/L)
**5% (856mEq/L)
**23.4% (4000mEq/L)
*Nebulized (as adjunct for [[bronchiolitis]], [[cystic fibrosis]])

==Adult Dosing==
===Symptomatic Hyponatremia===
*Bolus 100-250mL 3% NS 100cc bolus over 10min; repeat after 10min x1 if no improvement
===Elevated ICP===
*Most studies used 250 mL bolus of 7.5% NS with dextran<ref>Holmes, J. Therapeutic uses of Hypertonic Saline in the Critically Ill Emergency Department Patient. EB Medicine 2013</ref>
*Initial 250mL bolus of 3% will reduce ICP and can be delivered through a peripheral line
*Target Na 145-155 meq/dL

==Pediatric Dosing==
*Symptomatic hyponatremia: 2mL/kg of 3% over 10-60 minutes, repeat of up to 3 times
*Elevated ICP
**3% NS: 3-10 mL/kg over 10-60 minutes<ref>Kochanek PM, Carney N, Adelson PD, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents--second edition. Pediatr Crit Care Med. 2012;13 Suppl 1:S1-82.</ref>
**Titrate to serum Na 145-150

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
*[[Lactation risk categories|Lactation risk]]:
===Renal Dosing===
*Adult:
*Pediatric:
===Hepatic Dosing===
*Adult:
*Pediatric:

==Contraindications==
*Allergy to class/drug
*Hypernatremia
*Chronic hyponatremia
*Severe CHF (theoretical), volume overload

==Adverse Reactions==
===Serious===
*Hypotension (infusion rate-related)
*Metabolic acidosis
*Hypernatraemia
*Hypokalemia
*Volume overload
*Renal failure
*Coagulopathy
*Phlebitis, tissue necrosis if extravasates (need central line for concentrations >3%
*If Na+ corrected too quickly, central pontine myelinosis, seizure, encephalopathy

===Common===

==Pharmacology==
*Half-life: rapid onset of action (~10min), effect lasts ~1hr
*Metabolism:
*Excretion:

==Mechanism of Action==
*Raises serum Na+, osmotherapy

==Comments==

==See Also==
*[[Head trauma (main)]], [[Pediatric head trauma]]
*[[Elevated intracranial pressure]]
*[[Hyponatremia]]

==References==
<references/>
[[Category:Pharmacology]]