https://wikem.org/w/index.php?action=history&feed=atom&title=Hyoscyamine 2026-04-18T01:03:41Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Hyoscyamine&diff=171250&oldid=prev 2018-02-12T20:15:35Z

<p>Creation of Page</p> <p><b>Página nueva</b></p><div>==Administration==<br /> *Type: [[Anticholinergic]]<br /> *Dosage Forms: TAB 0.125mg; SL TAB: 0.125mg; INJ: 0.5 mg/mL; Drops 0.125 mg/mL<br /> *Routes of Administration: Oral, sublingual, IM/IV<br /> *Common Trade Names: Levsin<br /> <br /> ==Adult Dosing==<br /> ===GI Tract spasm===<br /> *0.125-0.25 mg PO/SL q4h prn<br /> **Max: 1.5 mg/day<br /> ===Bladder spasm===<br /> *0.125-0.25 mg PO/SL q4h prn<br /> **Max: 1.5 mg/day<br /> ===[[IBS]], adjunct tx===<br /> *0.125-0.25 mg PO/SL q4h prn<br /> **Max: 1.5 mg/day<br /> ===[[PUD]], adjunct tx===<br /> *0.125-0.25 mg PO/SL q4h prn<br /> **Max: 1.5 mg/day<br /> ===[[Parkinson's disease]], adjunct tx===<br /> *0.125-0.25 mg PO/SL q4h prn<br /> **Max: 1.5 mg/day<br /> ===Biliary colic, adjunct tx===<br /> *0.125-0.25 mg PO/SL q4h prn<br /> **Max: 1.5 mg/day<br /> ===Renal colic, adjunct tx===<br /> *0.125-0.25 mg PO/SL q4h prn<br /> **Max: 1.5 mg/day<br /> ===[[Rhinitis]]===<br /> *0.125-0.25 mg PO/SL q4h prn<br /> **Max: 1.5 mg/day<br /> ===Diagnostic procedures===<br /> *0.25-0.5mg SC/IM/IV x1<br /> ===Anesthesia adjunct===<br /> *5mcg/kg SC/IM/IV x1<br /> ===Surgery adjunct===<br /> *0.125 mg IV prn<br /> ===Cholinesterase overdose===<br /> *Give 0.3-0.6 mg IV for each 0.5-2 mg neostigmine or physostigmine<br /> <br /> ==Pediatric Dosing==<br /> ===[[Colic]], infantile===<br /> *&lt;2 yo, 3.4-4.9 kg<br /> **4 drops PO q4h prn<br /> *&lt;2 yo, 5-6.9 kg<br /> **5 drops PO q4h prn<br /> *&lt;2 yo, 7-9.9 kg<br /> **6 drops PO q4h prn<br /> *&lt;2 yo, &gt;10 kg<br /> **8 drops PO q4h prn<br /> ===Bladder or GI Tract spasm===<br /> *2-11 yo<br /> **0.0625-0.125 mg PO/SL q4h prn<br /> *12+ yo<br /> **0.125-0.25 mg PO/SL q4h prn<br /> ===Anesthesia adjunct===<br /> *&gt;2 yo<br /> **5 mcg/kg SC/IM/IV x1<br /> ==Special Populations==<br /> *[[Drug pregnancy categories|Pregnancy Rating]]: C<br /> *Lactation risk: Caution advised<br /> ===Renal Dosing===<br /> *Adult: Caution advised<br /> *Pediatric: Caution advised<br /> ===Hepatic Dosing===<br /> *Adult: Caution advised<br /> *Pediatric: Caution advised<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug<br /> *Glaucoma<br /> *GI obstruction or ileus<br /> *Intestinal atony in elderly pts<br /> *[[Ulcerative colitis]]<br /> *Obstructive uropathy<br /> *Prostatic hypertrophy<br /> *[[MI]]<br /> *Unstable cardiovascular status<br /> *Autonomic neuropathy<br /> *[[Toxic megacolon]]<br /> *[[Myasthenia gravis]]<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *[[Anaphylaxis]]<br /> *[[Heat stroke]]<br /> *IOP increase<br /> *[[Psychosis]], anticholinergic<br /> *[[Hallucinations]]<br /> <br /> ===Common===<br /> *Xerostermia<br /> *Dry eyes, blurred vision, mydriasis, cycloplegia<br /> *Urinary retention, [[constipation]], [[nausea]], [[vomiting]]<br /> *Confusion, impaired memory, excitement, nervousness<br /> *[[Tachycardia]], [[palpitations]]<br /> *Anhidrosis, flushing<br /> *Loss of taste<br /> *[[Headache]], [[Dizziness]]<br /> *[[Ataxia]]<br /> *Drowsiness, weakness, insomnia<br /> *[[Fever]]<br /> *Impotence, lactation suppression<br /> *[[Urticaria]]<br /> <br /> ==Pharmacology==<br /> *Half-life: 2-3.5 hr (7.5 hr ER form)<br /> *Metabolism: Liver<br /> *Excretion: Urine primarily (30-50% unchanged)<br /> <br /> ==Mechanism of Action==<br /> *Antagonizes acetylcholine receptors<br /> <br /> ==Comments==<br /> <br /> <br /> ==See Also==<br /> <br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Pharmacology]]</div>

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