Hirschsprung's disease - Revision history

Ostermayer: Prepared the page for translation

2026-01-04T23:06:11Z

Prepared the page for translation

← Revisión anterior		Revisión del 23:06 4 ene 2026
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			<languages/>
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	==Background==		==Background==

	[[File:Diameters of the large intestine.png\|thumb\|Average inner diameters and ranges of different sections of the large intestine.<ref> Nguyen H, Loustaunau C, Facista A, Ramsey L, Hassounah N, Taylor H, et al. (July 2010). "Deficient Pms2, ERCC1, Ku86, CcOI in field defects during progression to colon cancer". Journal of Visualized Experiments (41). doi:10.3791/1931. PMC 3149991. PMID 20689513.</ref>]]		[[File:Diameters of the large intestine.png\|thumb\|Average inner diameters and ranges of different sections of the large intestine.<ref> Nguyen H, Loustaunau C, Facista A, Ramsey L, Hassounah N, Taylor H, et al. (July 2010). "Deficient Pms2, ERCC1, Ku86, CcOI in field defects during progression to colon cancer". Journal of Visualized Experiments (41). doi:10.3791/1931. PMC 3149991. PMID 20689513.</ref>]]
	[[File:PMC4955449 AJPS-13-82-g004.png\|thumb\|(A) Showing point of calibre change in the colon. (B) Resection of the aganglionic bowel and the severely dilated proximal colon.]]		[[File:PMC4955449 AJPS-13-82-g004.png\|thumb\|(A) Showing point of calibre change in the colon. (B) Resection of the aganglionic bowel and the severely dilated proximal colon.]]
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	*30% associated with a syndrome		*30% associated with a syndrome
	*1:5,000 live births		*1:5,000 live births


	==Clinical Features==		==Clinical Features==

	[[File:PMC4955449 AJPS-13-82-g001.png\|thumb\|Three patients with late-diagnosis disease demonstrating abdominal distention.]]		[[File:PMC4955449 AJPS-13-82-g001.png\|thumb\|Three patients with late-diagnosis disease demonstrating abdominal distention.]]
	*Delayed meconium passage after birth		*Delayed meconium passage after birth
	*80% present within first month of life		*80% present within first month of life
	**May have delayed presentation in milder disease		**May have delayed presentation in milder disease
	*Chronic [[Constipation (peds)\|constipation]]		*Chronic [[Special:MyLanguage/Constipation (peds)\|constipation]]
	**Encopresis		**Encopresis
	**[[Rectal prolapse]]		**[[Special:MyLanguage/Rectal prolapse\|Rectal prolapse]]
	*[[Small bowel obstruction\|Obstruction]] symptoms		*[[Special:MyLanguage/Small bowel obstruction\|Obstruction]] symptoms
	**Neonatal [[toxic megacolon]] may occur		**Neonatal [[Special:MyLanguage/toxic megacolon\|toxic megacolon]] may occur
	***Distended abdomen, [[Nausea and vomiting (peds)\|bilious vomiting]], enterocolitis		***Distended abdomen, [[Special:MyLanguage/Nausea and vomiting (peds)\|bilious vomiting]], enterocolitis
	*Enterocolitis		*Enterocolitis
	**[[Diarrhea (peds)\|Diarrhea]], [[GI Bleeding (Peds)\|rectal bleeding]], abdominal distention, [[fever]]		**[[Special:MyLanguage/Diarrhea (peds)\|Diarrhea]], [[Special:MyLanguage/GI Bleeding (Peds)\|rectal bleeding]], abdominal distention, [[Special:MyLanguage/fever\|fever]]


	==Differential Diagnosis==		==Differential Diagnosis==

			</translate>
	{{Infant Constipation}}		{{Infant Constipation}}
			<translate>


	==Evaluation==		==Evaluation==

	[[File:PMC4955449 AJPS-13-82-g002.png\|thumb\|Abdominal X-ray showing: (A) Faecal stasis and huge dilated transverse colon. (B) Air fuid levels and cut-off sign.]]		[[File:PMC4955449 AJPS-13-82-g002.png\|thumb\|Abdominal X-ray showing: (A) Faecal stasis and huge dilated transverse colon. (B) Air fuid levels and cut-off sign.]]
	[[File:PMC4389175 Iranjradiol-12-02-12451-g001.png\|thumb\|Barium enema in neonate with Hirschsprung disease shows transitional zone and cobblestone appearance.]]		[[File:PMC4389175 Iranjradiol-12-02-12451-g001.png\|thumb\|Barium enema in neonate with Hirschsprung disease shows transitional zone and cobblestone appearance.]]
	[[File:PMC4389175 Iranjradiol-12-02-12451-g002.png\|thumb\|Barium enema in a 1-month-old male with Hirschsprung disease depicts bizarre irregular contraction.]]		[[File:PMC4389175 Iranjradiol-12-02-12451-g002.png\|thumb\|Barium enema in a 1-month-old male with Hirschsprung disease depicts bizarre irregular contraction.]]
	*[[KUB]] distended colon, empty rectum		*[[Special:MyLanguage/KUB\|KUB]] distended colon, empty rectum
	**Enterocolitis: distention, bowel wall thickening		**Enterocolitis: distention, bowel wall thickening
	**Obstruction: air fluid levels		**Obstruction: air fluid levels
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	**Sensitivity 70% and specificity of 83%		**Sensitivity 70% and specificity of 83%
	*Diagnosis requires rectal biopsy (consult GI)		*Diagnosis requires rectal biopsy (consult GI)


	==Management==		==Management==

	*Consult pediatric surgeon for operative management		*Consult pediatric surgeon for operative management
	*ED management may include gastric and rectal decompression		*ED management may include gastric and rectal decompression
	*Treat enterocolitis with broad spectrum [[antibiotics]]		*Treat enterocolitis with broad spectrum [[Special:MyLanguage/antibiotics\|antibiotics]]
	*Supportive fluid and electrolyte replacement		*Supportive fluid and electrolyte replacement


	==Disposition==		==Disposition==

	*Admit if symptoms of obstruction, enterocolitis		*Admit if symptoms of obstruction, enterocolitis


	==See Also==		==See Also==
	*[[Constipation (peds)]]
			*[[Special:MyLanguage/Constipation (peds)\|Constipation (peds)]]


	==External Links==		==External Links==
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	==References==		==References==

	<references/>		<references/>

	[[Category:Pediatrics]]		[[Category:Pediatrics]]
	[[Category:GI]]		[[Category:GI]]
			</translate>

Rossdonaldson1: /* Background */

2025-09-24T21:01:44Z

Background

← Revisión anterior		Revisión del 21:01 24 sep 2025
Línea 1:		Línea 1:
	==Background==		==Background==
			[[File:Diameters of the large intestine.png\|thumb\|Average inner diameters and ranges of different sections of the large intestine.<ref> Nguyen H, Loustaunau C, Facista A, Ramsey L, Hassounah N, Taylor H, et al. (July 2010). "Deficient Pms2, ERCC1, Ku86, CcOI in field defects during progression to colon cancer". Journal of Visualized Experiments (41). doi:10.3791/1931. PMC 3149991. PMID 20689513.</ref>]]
	[[File:PMC4955449 AJPS-13-82-g004.png\|thumb\|(A) Showing point of calibre change in the colon. (B) Resection of the aganglionic bowel and the severely dilated proximal colon.]]		[[File:PMC4955449 AJPS-13-82-g004.png\|thumb\|(A) Showing point of calibre change in the colon. (B) Resection of the aganglionic bowel and the severely dilated proximal colon.]]
	*Congenital aganglionosis of colon		*Congenital aganglionosis of colon

Rossdonaldson1: /* Evaluation */

2022-01-08T07:02:06Z

Evaluation

← Revisión anterior		Revisión del 07:02 8 ene 2022
Línea 29:		Línea 29:
	[[File:PMC4955449 AJPS-13-82-g002.png\|thumb\|Abdominal X-ray showing: (A) Faecal stasis and huge dilated transverse colon. (B) Air fuid levels and cut-off sign.]]		[[File:PMC4955449 AJPS-13-82-g002.png\|thumb\|Abdominal X-ray showing: (A) Faecal stasis and huge dilated transverse colon. (B) Air fuid levels and cut-off sign.]]
	[[File:PMC4389175 Iranjradiol-12-02-12451-g001.png\|thumb\|Barium enema in neonate with Hirschsprung disease shows transitional zone and cobblestone appearance.]]		[[File:PMC4389175 Iranjradiol-12-02-12451-g001.png\|thumb\|Barium enema in neonate with Hirschsprung disease shows transitional zone and cobblestone appearance.]]
			[[File:PMC4389175 Iranjradiol-12-02-12451-g002.png\|thumb\|Barium enema in a 1-month-old male with Hirschsprung disease depicts bizarre irregular contraction.]]
	*[[KUB]] distended colon, empty rectum		*[[KUB]] distended colon, empty rectum
	**Enterocolitis: distention, bowel wall thickening		**Enterocolitis: distention, bowel wall thickening

Rossdonaldson1: /* Clinical Features */

2022-01-08T07:00:45Z

Clinical Features

← Revisión anterior		Revisión del 07:00 8 ene 2022
Línea 10:		Línea 10:

	==Clinical Features==		==Clinical Features==
			[[File:PMC4955449 AJPS-13-82-g001.png\|thumb\|Three patients with late-diagnosis disease demonstrating abdominal distention.]]
	*Delayed meconium passage after birth		*Delayed meconium passage after birth
	*80% present within first month of life		*80% present within first month of life

Rossdonaldson1: /* Background */

2022-01-08T06:58:55Z

Background

← Revisión anterior		Revisión del 06:58 8 ene 2022
Línea 1:		Línea 1:
	==Background==		==Background==
			[[File:PMC4955449 AJPS-13-82-g004.png\|thumb\|(A) Showing point of calibre change in the colon. (B) Resection of the aganglionic bowel and the severely dilated proximal colon.]]
	*Congenital aganglionosis of colon		*Congenital aganglionosis of colon
	*Usually affects rectosigmoid area		*Usually affects rectosigmoid area

Rossdonaldson1: /* Evaluation */

2022-01-08T06:56:54Z

Evaluation

← Revisión anterior		Revisión del 06:56 8 ene 2022
Línea 25:		Línea 25:

	==Evaluation==		==Evaluation==
			[[File:PMC4955449 AJPS-13-82-g002.png\|thumb\|Abdominal X-ray showing: (A) Faecal stasis and huge dilated transverse colon. (B) Air fuid levels and cut-off sign.]]
	[[File:PMC4389175 Iranjradiol-12-02-12451-g001.png\|thumb\|Barium enema in neonate with Hirschsprung disease shows transitional zone and cobblestone appearance.]]		[[File:PMC4389175 Iranjradiol-12-02-12451-g001.png\|thumb\|Barium enema in neonate with Hirschsprung disease shows transitional zone and cobblestone appearance.]]
	*[[KUB]] distended colon, empty rectum		*[[KUB]] distended colon, empty rectum

Rossdonaldson1: /* Evaluation */

2022-01-08T06:17:25Z

Evaluation

← Revisión anterior		Revisión del 06:17 8 ene 2022
Línea 25:		Línea 25:

	==Evaluation==		==Evaluation==
			[[File:PMC4389175 Iranjradiol-12-02-12451-g001.png\|thumb\|Barium enema in neonate with Hirschsprung disease shows transitional zone and cobblestone appearance.]]
	*[[KUB]] distended colon, empty rectum		*[[KUB]] distended colon, empty rectum
	**Enterocolitis: distention, bowel wall thickening		**Enterocolitis: distention, bowel wall thickening

ClaireLewis: /* Clinical Features */

2019-09-29T21:18:53Z

Clinical Features

← Revisión anterior		Revisión del 21:18 29 sep 2019
Línea 19:		Línea 19:
	***Distended abdomen, [[Nausea and vomiting (peds)\|bilious vomiting]], enterocolitis		***Distended abdomen, [[Nausea and vomiting (peds)\|bilious vomiting]], enterocolitis
	*Enterocolitis		*Enterocolitis
	**[[Diarrhea (peds)\|Diarrhea]], [[GI Bleeding (~~peds~~)\|rectal bleeding]], abdominal distention, [[fever]]		**[[Diarrhea (peds)\|Diarrhea]], [[GI Bleeding (Peds)\|rectal bleeding]], abdominal distention, [[fever]]

	==Differential Diagnosis==		==Differential Diagnosis==

ClaireLewis at 21:18, 29 September 2019

2019-09-29T21:18:38Z

← Revisión anterior		Revisión del 21:18 29 sep 2019
Línea 19:		Línea 19:
	***Distended abdomen, [[Nausea and vomiting (peds)\|bilious vomiting]], enterocolitis		***Distended abdomen, [[Nausea and vomiting (peds)\|bilious vomiting]], enterocolitis
	*Enterocolitis		*Enterocolitis
	**[[Diarrhea (peds)\|Diarrhea]], rectal bleeding, abdominal distention, [[fever]]		**[[Diarrhea (peds)\|Diarrhea]], [[GI Bleeding (peds)\|rectal bleeding]], abdominal distention, [[fever]]

	==Differential Diagnosis==		==Differential Diagnosis==

Mholtz at 05:31, 4 November 2018

2018-11-04T05:31:56Z

← Revisión anterior		Revisión del 05:31 4 nov 2018
Línea 1:		Línea 1:
	==Background==		==Background==
	*Congenital aganglionosis of colon		*Congenital aganglionosis of colon
	**Usually rectosigmoid area		*Usually affects rectosigmoid area
	***Short segment affects rectum and small amount of distal colon		**Short segment affects rectum and small amount of distal colon
	***Long segment affects more of colon, proximal intestine		**Long segment affects more of colon, proximal intestine
	**Rarely involves more proximal intestine		**Rarely involves more proximal intestine
	*30% associated with a syndrome		*30% associated with a syndrome
Línea 34:		Línea 34:
	==Management==		==Management==
	*Consult pediatric surgeon for operative management		*Consult pediatric surgeon for operative management
	**ED management may include gastric and rectal decompression		*ED management may include gastric and rectal decompression
	**Treat enterocolitis with broad spectrum [[antibiotics]]		*Treat enterocolitis with broad spectrum [[antibiotics]]
	*Supportive fluid and electrolyte replacement		*Supportive fluid and electrolyte replacement

Línea 45:		Línea 45:

	==External Links==		==External Links==


	==References==		==References==