Henoch-Schonlein purpura - Revision history

Danbot: Add MedicationDose entry (prednisone) with SMW annotations

2026-03-20T18:43:53Z

Add MedicationDose entry (prednisone) with SMW annotations

@@ Línea 73: / Línea 73: @@
 *Recurrence rate of up to 33%
 *Indications for admission include renal failure, significant GI bleeding, and intussusception. <ref>Core EM Henoch-Schoenlein Purpura https://coreem.net/core/henoch-schoenlein-purpura/</ref>
 ==See Also==

Rossdonaldson1: /* Background */

2024-12-11T16:26:03Z

Background

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	==Background==		==Background==
			{{Skin anatomy background images}}
	*Abbreviation: HSP		*Abbreviation: HSP
	*Classical triad of non-thrombocytopenic palpable [[purpura]], [[abdominal pain]], [[arthritis]]		*Classical triad of non-thrombocytopenic palpable [[purpura]], [[abdominal pain]], [[arthritis]]

Rossdonaldson1: /* Background */

2023-08-02T17:46:06Z

Background

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	**Presentation in adults is often worse, with persisting renal insufficiency in 30-50%		**Presentation in adults is often worse, with persisting renal insufficiency in 30-50%
	**Adults may require more aggressive treatment with [[steroids]] +/- [[cyclophosphamide]] though evidence of benefit is lacking		**Adults may require more aggressive treatment with [[steroids]] +/- [[cyclophosphamide]] though evidence of benefit is lacking

			{{Primary Vasculitis DDX}}

	==Clinical Features==		==Clinical Features==

Hoxbox: /* Disposition */

2020-10-22T18:37:16Z

Disposition

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	*Outpatient renal consult		*Outpatient renal consult
	*Recurrence rate of up to 33%		*Recurrence rate of up to 33%
			*Indications for admission include renal failure, significant GI bleeding, and intussusception. <ref>Core EM Henoch-Schoenlein Purpura https://coreem.net/core/henoch-schoenlein-purpura/</ref>

	==See Also==		==See Also==

ClaireLewis: /* Management */

2019-09-15T00:45:20Z

Management

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	*[[NSAIDs]] for pain, may worsen renal disease or GI disease		*[[NSAIDs]] for pain, may worsen renal disease or GI disease
	*Consider [[prednisone]] 1mg/kg/day for severe arthralgias, abdominal or scrotal disease		*Consider [[prednisone]] 1mg/kg/day for severe arthralgias, abdominal or scrotal disease
	*May require IVIG to prevent and treat glomerulonephritis		*May require [[IVIG]] to prevent and treat [[glomerulonephritis]]

	==Disposition==		==Disposition==

Kxl328: /* Management */

2018-10-07T19:27:49Z

Management

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	*[[NSAIDs]] for pain, may worsen renal disease or GI disease		*[[NSAIDs]] for pain, may worsen renal disease or GI disease
	*Consider [[prednisone]] 1mg/kg/day for severe arthralgias, abdominal or scrotal disease		*Consider [[prednisone]] 1mg/kg/day for severe arthralgias, abdominal or scrotal disease
			*May require IVIG to prevent and treat glomerulonephritis

	==Disposition==		==Disposition==

Kxl328: /* Rare manifestations */

2018-10-07T19:26:47Z

Rare manifestations

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	*[[Fever]]		*[[Fever]]
	*Non-pitting edema of the extremities and face		*Non-pitting edema of the extremities and face
	*~~[[Nephrotic syndrome]]~~		*Nephritic range proteinuria
	**Long-term mortality directly related to renal involvement<ref>Calviño, MC, Llorca, J, García-Porrúa, C, Fernández-Iglesias, JL, Rodriguez-Ledo, P, González-Gay, MA (2001) Henoch-Schönlein purpura in children from northwestern Spain: a 20-year epidemiologic and clinical study. Medicine (Baltimore) 80: pp. 279-290 </ref><ref>Saulsbury, FT (1999) Henoch-Schönlein purpura in children. Report of 100 patients and review of the literature. Medicine (Baltimore) 78: pp. 395-409 </ref>		**Long-term mortality directly related to renal involvement<ref>Calviño, MC, Llorca, J, García-Porrúa, C, Fernández-Iglesias, JL, Rodriguez-Ledo, P, González-Gay, MA (2001) Henoch-Schönlein purpura in children from northwestern Spain: a 20-year epidemiologic and clinical study. Medicine (Baltimore) 80: pp. 279-290 </ref><ref>Saulsbury, FT (1999) Henoch-Schönlein purpura in children. Report of 100 patients and review of the literature. Medicine (Baltimore) 78: pp. 395-409 </ref>

Mholtz: Text replacement - "* " to "*"

2017-07-10T13:27:35Z

Text replacement - "* " to "*"

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	==Evaluation==		==Evaluation==
	* Usually a clinical diagnosis — rule out other causes		*Usually a clinical diagnosis — rule out other causes
	** No lab test is diagnostic		**No lab test is diagnostic
	** Biopsy of affected organ (eg skin or kidney) with predominantly IgA deposition supports diagnosis		**Biopsy of affected organ (eg skin or kidney) with predominantly IgA deposition supports diagnosis
	* CBC (increased WBC and PLT)		*CBC (increased WBC and PLT)
	* CRP/ESR (increased)		*CRP/ESR (increased)
	* Chemistry		*Chemistry
	* PT/PTT (normal)		*PT/PTT (normal)
	* [[Urinalysis]] ([[hematuria]], proteinuria)		*[[Urinalysis]] ([[hematuria]], proteinuria)
	* Stool guaiac (positive in >50%)<ref>Chang WL, Yang YH, Lin YT, Chiang BL. "Gastrointestinal manifestations in Henoch-Schönlein purpura: a review of 261 patients." Acta Paediatr. 2004;93(11):1427.</ref> — indicates GI vasculitis		*Stool guaiac (positive in >50%)<ref>Chang WL, Yang YH, Lin YT, Chiang BL. "Gastrointestinal manifestations in Henoch-Schönlein purpura: a review of 261 patients." Acta Paediatr. 2004;93(11):1427.</ref> — indicates GI vasculitis
	* Consider abdominal ultrasound — increased risk of [[intussusception]]		*Consider abdominal ultrasound — increased risk of [[intussusception]]

	==Management==		==Management==

Mholtz at 01:13, 10 July 2017

2017-07-10T01:13:33Z

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	{{Glomerulonephritis causes}}		{{Glomerulonephritis causes}}

	== Evaluation ==		==Evaluation==
			* Usually a clinical diagnosis — rule out other causes
	~~=== Work-Up ===~~		** No lab test is diagnostic
			** Biopsy of affected organ (eg skin or kidney) with predominantly IgA deposition supports diagnosis
	* CBC (increased WBC and PLT)		* CBC (increased WBC and PLT)
	* CRP/ESR (increased)		* CRP/ESR (increased)
Línea 58:		Línea 58:
	* Stool guaiac (positive in >50%)<ref>Chang WL, Yang YH, Lin YT, Chiang BL. "Gastrointestinal manifestations in Henoch-Schönlein purpura: a review of 261 patients." Acta Paediatr. 2004;93(11):1427.</ref> — indicates GI vasculitis		* Stool guaiac (positive in >50%)<ref>Chang WL, Yang YH, Lin YT, Chiang BL. "Gastrointestinal manifestations in Henoch-Schönlein purpura: a review of 261 patients." Acta Paediatr. 2004;93(11):1427.</ref> — indicates GI vasculitis
	* Consider abdominal ultrasound — increased risk of [[intussusception]]		* Consider abdominal ultrasound — increased risk of [[intussusception]]

	~~=== Evaluation ===~~

	* Usually a clinical diagnosis — rule out other causes
	** No lab test is diagnostic
	** Biopsy of affected organ (eg skin or kidney) with predominantly IgA deposition supports diagnosis

	==Management==		==Management==
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	==References==		==References==
	<references/>		<references/>


	[[Category:Dermatology]]		[[Category:Dermatology]]
	[[Category:Pediatrics]]		[[Category:Pediatrics]]

Iaso: /* Evaluation */

2017-02-23T15:35:20Z

Evaluation

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	* PT/PTT (normal)		* PT/PTT (normal)
	* [[Urinalysis]] ([[hematuria]], proteinuria)		* [[Urinalysis]] ([[hematuria]], proteinuria)
	* Stool guaiac (positive in >50%)<ref>Chang WL, Yang YH, Lin YT, Chiang BL. "Gastrointestinal manifestations in Henoch-Schönlein purpura: a review of 261 patients." Acta Paediatr. 2004;93(11):1427.</ref>		* Stool guaiac (positive in >50%)<ref>Chang WL, Yang YH, Lin YT, Chiang BL. "Gastrointestinal manifestations in Henoch-Schönlein purpura: a review of 261 patients." Acta Paediatr. 2004;93(11):1427.</ref> — indicates GI vasculitis
	* Consider abdominal ultrasound — increased risk of [[intussusception]]		* Consider abdominal ultrasound — increased risk of [[intussusception]]