https://wikem.org/w/index.php?action=history&feed=atom&title=Heliox 2026-04-16T14:02:27Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Heliox&diff=389791&oldid=prev 2026-03-25T02:57:41Z

<p>Created Heliox medication page with standard template</p> <p><b>Página nueva</b></p><div>==Administration==<br /> *Type: Medical gas, [[Bronchodilator]] adjunct<br /> *Dosage Forms: Premixed gas cylinders (typically 80:20 or 70:30 helium:oxygen)<br /> *Routes of Administration: Inhaled (face mask or non-rebreather)<br /> *Common Trade Names: Heliox (generic)<br /> <br /> ==Adult Dosing==<br /> *80:20 heliox (80% helium, 20% oxygen): preferred for maximum benefit; use when FiO2 requirements are low<br /> *70:30 heliox (70% helium, 30% oxygen): use when higher FiO2 is needed<br /> *Administer continuously via non-rebreather mask or tight-fitting face mask<br /> *Can be used as driving gas for nebulized medications (set flow to 11-15 L/min)<br /> *Effect is immediate; benefit lost when removed<br /> <br /> ==Pediatric Dosing==<br /> *Same concentrations as adult (70:30 or 80:20)<br /> *Delivered via tight-fitting mask appropriate to size<br /> <br /> ==Special Populations==<br /> ===[[Drug pregnancy categories|Pregnancy Rating]]===<br /> *Safe; no systemic absorption<br /> <br /> ===Lactation risk===<br /> *Safe; no systemic absorption<br /> <br /> ===Renal Dosing===<br /> *Adult: No adjustment needed<br /> *Pediatric: No adjustment needed<br /> <br /> ===Hepatic Dosing===<br /> *Adult: No adjustment needed<br /> *Pediatric: No adjustment needed<br /> <br /> ==Contraindications==<br /> *Hypoxemia requiring FiO2 &gt;30-40% (limits helium concentration below therapeutic threshold)<br /> *Need for high-flow supplemental oxygen<br /> *Pneumothorax (theoretical concern regarding gas trapping)<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *Hypoxia (if oxygen concentration insufficient for patient needs)<br /> <br /> ===Common===<br /> *Voice change (higher pitch due to helium)<br /> *Feeling of dyspnea (lower gas density feels different)<br /> <br /> ==Pharmacology==<br /> *Half-life: N/A (inert gas, not metabolized)<br /> *Metabolism: None; helium is biologically inert<br /> *Excretion: Eliminated via exhalation<br /> <br /> ==Mechanism of Action==<br /> *Helium is less dense than nitrogen (1/7th the density)<br /> *Reduces gas mixture density, converting turbulent airflow to laminar flow in narrowed airways<br /> *Decreases airway resistance and work of breathing<br /> *Does not treat underlying pathology — serves as bridge therapy while definitive treatments take effect<br /> <br /> ==Comments==<br /> *Temporizing measure only — does not treat the underlying cause of airway obstruction<br /> *Most effective when obstruction is in large/central airways (upper airway obstruction, post-extubation stridor)<br /> *Less effective for peripheral small airway disease<br /> *Clinical use in [[acute asthma exacerbation|asthma]] is controversial; evidence is mixed<br /> *Better evidence for upper airway obstruction ([[croup]], tracheal tumors, post-extubation stridor)<br /> *Requires tight-fitting mask delivery system; entrainment of room air negates benefit<br /> *Cannot be reliably delivered via nasal cannula<br /> *Pulse oximetry readings may be inaccurate during heliox use<br /> *Can improve nebulizer drug delivery to distal airways when used as driving gas<br /> <br /> ==Indications by Condition==<br /> ''The following table is automatically generated from disease/condition pages across WikEM.''<br /> {{#ask:[[Has DrugName::Heliox]]<br /> |?Has Indication=Indication<br /> |?Has Dose=Dose<br /> |?Has Context=Context<br /> |?Has Route=Route<br /> |?Has Population=Population<br /> |format=table<br /> |headers=plain<br /> |mainlabel=-<br /> |sort=Has Indication<br /> |limit=50<br /> }}<br /> <br /> ==See Also==<br /> *[[Acute asthma exacerbation]]<br /> *[[Croup]]<br /> *[[Upper airway obstruction]]<br /> *[[COPD exacerbation]]<br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Pharmacology]]</div>

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