Glycopyrrolate - Revision history

Masoodrm: /* Administration */

2022-05-06T17:14:32Z

Administration

← Revisión anterior		Revisión del 17:14 6 may 2022
Línea 1:		Línea 1:
	==Administration==		==Administration==
	*~~Type~~: [[Anticholinergics]]		*Class: [[Anticholinergics]]
	*Dosage Forms: Oral tab 1mg; INJ		*Routes of Administration: Oral, IV, IM
	*Routes of Administration: Oral, IM, IV		*Dosage Forms: 1-2 mg tablets, 1 mg/5mL oral solution, 0.2 mg/mL injectable solution
	*Common Trade Names: Robinul, Cuvposa		*Common Trade Names: Robinul, Cuvposa

Elcatracho: /* Administration */

2021-03-06T10:33:51Z

Administration

← Revisión anterior		Revisión del 10:33 6 mar 2021
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	*Dosage Forms: Oral tab 1mg; INJ		*Dosage Forms: Oral tab 1mg; INJ
	*Routes of Administration: Oral, IM, IV		*Routes of Administration: Oral, IM, IV
	*Common Trade Names: Robinul		*Common Trade Names: Robinul, Cuvposa

	==Adult Dosing==		==Adult Dosing==

Mholtz: Text replacement - "w/ " to "with "

2017-07-17T14:34:08Z

Text replacement - "w/ " to "with "

← Revisión anterior		Revisión del 14:34 17 jul 2017
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	==Special Populations==		==Special Populations==
	*[[Drug pregnancy categories\|Pregnancy Rating]]: B; No known risk of teratogenicity w/ INJ form at 5x MRHD and w/ PO form at 320x MRHD		*[[Drug pregnancy categories\|Pregnancy Rating]]: B; No known risk of teratogenicity with INJ form at 5x MRHD and with PO form at 320x MRHD
	*Lactation risk: L3; Safety unknown		*Lactation risk: L3; Safety unknown

Línea 48:		Línea 48:
	*Intestinal atony in elderly, debilitated pts		*Intestinal atony in elderly, debilitated pts
	*[[Myasthenia gravis]]		*[[Myasthenia gravis]]
	*Acute hemorrhage w/ unstable cardiovascular status		*Acute hemorrhage with unstable cardiovascular status
	*Caution if CAD		*Caution if CAD
	*Caution if [[HTN]]		*Caution if [[HTN]]
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	*Caution if [[febrile]]		*Caution if [[febrile]]
	*Caution if [[ulcerative colitis]]		*Caution if [[ulcerative colitis]]
	*Caution if hiatal hernia w/ reflux [[esophagitis]]		*Caution if hiatal hernia with reflux [[esophagitis]]

	==Adverse Reactions==		==Adverse Reactions==

Mholtz: Text replacement - "qid" to "QID"

2017-07-07T12:12:59Z

Text replacement - "qid" to "QID"

← Revisión anterior		Revisión del 12:12 7 jul 2017
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	***Start: 1 mg PO tid		***Start: 1 mg PO tid
	***Max: 8 mg/day		***Max: 8 mg/day
	**IM/IV Dose: 0.1-0.2 mg IM/IV tid-~~qid~~		**IM/IV Dose: 0.1-0.2 mg IM/IV tid-QID
	***Max: 0.8 mg/day		***Max: 0.8 mg/day
	***Space dose 4h apart		***Space dose 4h apart

Mholtz: Text replacement - "prn" to "PRN"

2017-07-07T08:43:11Z

Text replacement - "prn" to "PRN"

← Revisión anterior		Revisión del 08:43 7 jul 2017
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	**PO Dose: 1-2 mg PO bid-tid;		**PO Dose: 1-2 mg PO bid-tid;
	***Max: 8 mg/day		***Max: 8 mg/day
	**Parenteral Dose: 0.1-0.2 mg SC/IM/IV q4-8h ~~prn~~		**Parenteral Dose: 0.1-0.2 mg SC/IM/IV q4-8h PRN
	***Max: 0.8 mg/day		***Max: 0.8 mg/day

	==Pediatric Dosing==		==Pediatric Dosing==
	*Antisialagogue		*Antisialagogue
	**PO Dose, 2+ yo: 0.04-0.1 mg/kg PO q4-8h ~~prn~~		**PO Dose, 2+ yo: 0.04-0.1 mg/kg PO q4-8h PRN
	***Max: 1-2 mg/dose, 8mg/day		***Max: 1-2 mg/dose, 8mg/day
	**Parenteral Dose, 2+ yo: 0.0004-0.01 mg/kg SC/IM/IV q4-8h ~~prn~~		**Parenteral Dose, 2+ yo: 0.0004-0.01 mg/kg SC/IM/IV q4-8h PRN
	***Max: 0.1-0.2 mg/dose, 0.8 mg/day		***Max: 0.1-0.2 mg/dose, 0.8 mg/day

ClaireLewis: /* Administration */

2017-02-26T02:08:01Z

Administration

← Revisión anterior		Revisión del 02:08 26 feb 2017
Línea 1:		Línea 1:
	==Administration==		==Administration==
	*Type: [[~~Anticholinergic~~]]		*Type: [[Anticholinergics]]
	*Dosage Forms: Oral tab 1mg; INJ		*Dosage Forms: Oral tab 1mg; INJ
	*Routes of Administration: Oral, IM, IV		*Routes of Administration: Oral, IM, IV

ClaireLewis: /* Administration */

2017-02-26T02:07:51Z

Administration

← Revisión anterior		Revisión del 02:07 26 feb 2017
Línea 1:		Línea 1:
	==Administration==		==Administration==
	*Type: Anticholinergic		*Type: [[Anticholinergic]]
	*Dosage Forms: Oral tab 1mg; INJ		*Dosage Forms: Oral tab 1mg; INJ
	*Routes of Administration: Oral, IM, IV		*Routes of Administration: Oral, IM, IV

Jonwarren: Creation of page

2017-02-01T07:40:48Z

Creation of page

Página nueva

==Administration==
*Type: Anticholinergic
*Dosage Forms: Oral tab 1mg; INJ
*Routes of Administration: Oral, IM, IV
*Common Trade Names: Robinul

==Adult Dosing==
*[[PUD]], adjunct tx
**PO Dose: 1-2 mg PO bid-tid;
***Start: 1 mg PO tid
***Max: 8 mg/day
**IM/IV Dose: 0.1-0.2 mg IM/IV tid-qid
***Max: 0.8 mg/day
***Space dose 4h apart
*Antisialagogue
**PO Dose: 1-2 mg PO bid-tid;
***Max: 8 mg/day
**Parenteral Dose: 0.1-0.2 mg SC/IM/IV q4-8h prn
***Max: 0.8 mg/day

==Pediatric Dosing==
*Antisialagogue
**PO Dose, 2+ yo: 0.04-0.1 mg/kg PO q4-8h prn
***Max: 1-2 mg/dose, 8mg/day
**Parenteral Dose, 2+ yo: 0.0004-0.01 mg/kg SC/IM/IV q4-8h prn
***Max: 0.1-0.2 mg/dose, 0.8 mg/day

==Special Populations==
*[[Drug pregnancy categories|Pregnancy Rating]]: B; No known risk of teratogenicity w/ INJ form at 5x MRHD and w/ PO form at 320x MRHD
*Lactation risk: L3; Safety unknown

===Renal Dosing===
*Adult: Not defined; consider decreased dose.
*Pediatric: No defined; consider decreased dose.
===Hepatic Dosing===
*Adult: Not defined.
*Pediatric: Not defined.

==Contraindications==
*Allergy to class/drug
*Neonates (benzyl alcohol-containing INJ forms)
*[[Glaucoma]], angle-closure
*Obstructive uropathy
*GI Obstruction
*Paralytic ileus
*[[Toxic megacolon]]
*[[Ulcerative colitis]], severe
*Intestinal atony in elderly, debilitated pts
*[[Myasthenia gravis]]
*Acute hemorrhage w/ unstable cardiovascular status
*Caution if CAD
*Caution if [[HTN]]
*Caution if [[CHF]]
*Caution if [[arrhythmia]]
*Caution in elderly/debilitated pts
*Caution if renal impairment
*Caution if pulmonary disease
*Caution if [[hyperthyroidism]]
*Caution if autonomic neuropathy
*Caution if BPH
*Caution if high environmental temperature
*Caution if [[febrile]]
*Caution if [[ulcerative colitis]]
*Caution if hiatal hernia w/ reflux [[esophagitis]]

==Adverse Reactions==
===Serious===
*Hypersensitivity reaction
*[[Anaphylaxis]]
*Intestinal obstruction
*[[Heat stroke]]
*[[Seizure]]
*[[Arrhythmia]]
*[[Cardiac arrest]]
*[[Respiratory arrest]]

===Common===
*Xerostomia
*[[Vomiting]]
*[[Constipation]]
*Flushing
*[[Headache]]
*[[Urinary retention]]
*Urinary hesitancy
*Blurred vision
*Palpation
*[[Tachycardia]]
*Anhidrosis
*Dysgeusia
*Lactation suppression

==Pharmacology==
*Half-life: 0.83h
*Metabolism: Unknown
*Excretion: Urine 85%, bile

==Mechanism of Action==
*Antagonizes acetylcholine receptors.

==Comments==

==See Also==

==References==
<references/>

[[Category:Pharmacology]]