Gemifloxacin - Revision history

Danbot: Add AntibioticDose SMW query table for dynamic indications by disease

2026-03-20T20:38:18Z

Add AntibioticDose SMW query table for dynamic indications by disease

@@ Línea 11: / Línea 11: @@
 ===Gonoccocal infection===
 *320mg PO x1 with [[azithromycin]]
 ==Pediatric Dosing==
 *No current dosing
 ==Special Populations==

Ostermayer at 17:06, 18 July 2025

2025-07-18T17:06:15Z

← Revisión anterior		Revisión del 17:06 18 jul 2025
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	==General==		==General==
	*Type: [[Is Generation:: 4th ~~Generation~~]] [[Is DrugClass::Fluoroquinolones]]		*Type: [[Is Generation:: 4th generation]] [[Is DrugClass::Fluoroquinolones]]
	*Dosage Forms: Oral (320mg)		*Dosage Forms: Oral (320mg)
	*Common Trade Names: Factive		*Common Trade Names: Factive

Ostermayer at 17:04, 18 July 2025

2025-07-18T17:04:21Z

← Revisión anterior		Revisión del 17:04 18 jul 2025
Línea 1:		Línea 1:
	==General==		==General==
	*Type: [[Is DrugClass::Fluoroquinolones]]		*Type: [[Is Generation:: 4th Generation]] [[Is DrugClass::Fluoroquinolones]]
	*Dosage Forms: Oral (320mg)		*Dosage Forms: Oral (320mg)
	*Common Trade Names: Factive		*Common Trade Names: Factive

Ostermayer at 16:43, 18 July 2025

2025-07-18T16:43:41Z

← Revisión anterior		Revisión del 16:43 18 jul 2025
Línea 1:		Línea 1:
	==General==		==General==
	*Type: [[~~Fluoroquinolone~~]]		*Type: [[Is DrugClass::Fluoroquinolones]]
	*Dosage Forms: Oral (320mg)		*Dosage Forms: Oral (320mg)
	*Common Trade Names: Factive		*Common Trade Names: Factive

ClaireLewis: /* References */

2019-09-22T20:09:23Z

References

← Revisión anterior		Revisión del 20:09 22 sep 2019
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	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:ID]]

Jonwarren: Updated all sections

2017-10-17T18:23:00Z

Updated all sections

← Revisión anterior		Revisión del 18:23 17 oct 2017
Línea 1:		Línea 1:
	==General==		==General==
	*Type:		*Type: [[Fluoroquinolone]]
	*Dosage Forms:		*Dosage Forms: Oral (320mg)
	*Common Trade Names: Factive		*Common Trade Names: Factive

	==Adult Dosing==		==Adult Dosing==
			===[[Pneumonia]], community-acquired===
			*320 mg PO q24h for at least 5 days
			===Chronic [[bronchitis]], acute bacterial exacerbation===
			*320 mg PO q24h x5 days
			===Gonoccocal infection===
			*320mg PO x1 with [[azithromycin]]

	==Pediatric Dosing==		==Pediatric Dosing==
			*No current dosing

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]:		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C; potential for fetotoxicity at higher doses
	*Lactation:		*Lactation: L3; no human data available.
	*Renal Dosing		*Renal Dosing
	**Adult		**Adult
			***CrCl <40: 160mg q24h
			***HD/PD: No supplement
	**Pediatric		**Pediatric
			***N/A
	*Hepatic Dosing		*Hepatic Dosing
	**Adult		**Adult
			***No adjustment
	**Pediatric		**Pediatric
			***N/A

	==Contraindications==		==Contraindications==
	*Allergy to class/drug		*Allergy to class/drug
			*[[Myasthenia gravis]]
			*[[QT prolongation]]
			*Uncorrected electrolyte abnormaliteis

	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
			*[[Anaphylaxis]], hypersensitivity reaction
			*C. Diff associated [[diarrhea]]
			*[[Seizures]]
			*Toxic psychosis, [[depression]], suicidality
			*[[Hyperglycemia]]
			*Phototoxicity
			*Vasulitis
			*Serum sickness
			*Hepatotoxicity, Nephrotoxicity
			*Myelosuppression, Blood dyscrasias
			*[[QT Prolongation]], [[Torsades de pointes]]
			*Peripheral neuropathy
			*Tendon rupture
			*Arthropathy
			*[[Myasthenia gravis]] exacerbation

	===Common===		===Common===
			*[[Diarrhea]], [[nausea]], [[Vomiting]]
			*[[Headache]], dizziness
			*Rash
			*Tendinitis
			*[[Arthralgia]], [[Myalgia]]
			*Insomnia, anxiety, confusion

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 7h
	*Metabolism:		*Metabolism: Liver minimally
	*Excretion:		*Excretion: Feces 61%, Urine 36%
	*Mechanism of Action:		*Mechanism of Action: Inhibits DNA gyrase and topoisomerase IV

	==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==		==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==

Mholtz at 23:19, 30 August 2017

2017-08-30T23:19:29Z

← Revisión anterior		Revisión del 23:19 30 ago 2017
Línea 2:		Línea 2:
	*Type:		*Type:
	*Dosage Forms:		*Dosage Forms:
	*Common Trade Names:		*Common Trade Names: Factive

	==Adult Dosing==		==Adult Dosing==
Línea 156:		Línea 156:
	==See Also==		==See Also==

	==~~Source~~==		==References==
			<references/>

	~~<references/>~~
	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Ostermayer: Text replacement - "Category:Drugs" to "Category:Pharmacology"

2016-03-22T15:54:22Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"

← Revisión anterior		Revisión del 15:54 22 mar 2016
Línea 159:		Línea 159:

	<references/>		<references/>
	[[Category:~~Drugs~~]]		[[Category:Pharmacology]]

Rossdonaldson1 at 01:51, 19 September 2014

2014-09-19T01:51:12Z

← Revisión anterior		Revisión del 01:51 19 sep 2014
Línea 159:		Línea 159:

	<references/>		<references/>
			[[Category:Drugs]]

Rossdonaldson1: Created page with "==General== Type: Dosage Forms: Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== Pregnancy Rating: *Lac..."

2014-06-24T03:43:15Z

Created page with "==General== *Type: *Dosage Forms: *Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== *Pregnancy Rating: *Lac..."

Página nueva

==General==
*Type:
*Dosage Forms:
*Common Trade Names:

==Adult Dosing==

==Pediatric Dosing==

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
*Lactation:
*Renal Dosing
**Adult
**Pediatric
*Hepatic Dosing
**Adult
**Pediatric

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===

===Common===

==Pharmacology==
*Half-life:
*Metabolism:
*Excretion:
*Mechanism of Action:

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||'''S'''
|-
| ||[[Enterococcus faecalis]]||'''S'''
|-
| ||[[Enterococcus faecium]]||I
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||I
|-
| ||[[CA-MRSA]]||I
|-
| ||[[Staph. Epidermidis]]||'''S'''
|-
| ||[[C. jeikeium]]||X1
|-
| ||[[L. monocytogenes]]||'''S'''
|-
| Gram Negatives||[[N. gonorrhoeae]]||I
|-
| ||[[N. meningitidis]]||X1
|-
| ||[[Moraxella catarrhalis]]||'''S'''
|-
| ||[[H. influenzae]]||'''S'''
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||'''S'''
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||'''S'''
|-
| ||[[Enterobacter]] sp, AmpC pos||'''S'''
|-
| ||[[Serratia]] sp||X1
|-
| ||Serratia marcescens||X1
|-
| ||[[Salmonella]] sp||X1
|-
| ||[[Shigella]] sp||X1
|-
| ||[[Proteus mirabilis]]||X1
|-
| ||[[Proteus vulgaris]]||'''S'''
|-
| ||[[Providencia sp.]]||X1
|-
| ||[[Morganella sp.]]||X1
|-
| ||[[Citrobacter freundii]]||X1
|-
| ||[[Citrobacter diversus]]||X1
|-
| ||[[Citrobacter sp.]]||X1
|-
| ||[[Aeromonas sp]]||X1
|-
| ||[[Acinetobacter sp.]]||I
|-
| ||[[Pseudomonas aeruginosa]]||X1
|-
| ||[[Burkholderia cepacia]]||X1
|-
| ||[[Stenotrophomonas maltophilia]]||X1
|-
| ||[[Yersinia enterocolitica]]||X1
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||'''S'''
|-
| ||[[Pasteurella multocida]]||X1
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||'''S'''
|-
| ||[[Mycoplasm pneumoniae]]||'''S'''
|-
| ||[[Rickettsia sp]]||X1
|-
| ||[[Mycobacterium avium]]||X1
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||R
|-
| ||[[Prevotella melaninogenica]]||X1
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||X1
|-
| ||[[Fusobacterium necrophorum]]||X1
|-
| ||[[Peptostreptococcus sp.]]||X1
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==

==Source==

<references/>