Fosphenytoin - Revision history

Danbot: Add peer-reviewed references with PMIDs

2026-03-22T09:58:31Z

Add peer-reviewed references with PMIDs

← Revisión anterior		Revisión del 09:58 22 mar 2026
Línea 15:		Línea 15:
	**Maximum IV rate of 150mg PE/min		**Maximum IV rate of 150mg PE/min
	*Monitor: [[phenytoin]] level 2 hr after IV, 4 hr after IM		*Monitor: [[phenytoin]] level 2 hr after IV, 4 hr after IM
	*All dosing in mg "phenytoin equivalents" (PE); 75mg fosphenytoin equivalent to 50mg [[phenytoin]]		*All dosing in mg "phenytoin equivalents" (PE); 75mg fosphenytoin equivalent to 50mg [[phenytoin]]<ref>Fischer JH, et al. Fosphenytoin: clinical pharmacokinetics and comparative advantages in the acute treatment of seizures. Clin Pharmacokinet. 2003;42(1):33-58. PMID 12489978</ref>

	==Pediatric Dosing==		==Pediatric Dosing==

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:58:24Z

Switch SMW query from broadtable to table format for better layout with TOC

← Revisión anterior		Revisión del 21:58 20 mar 2026
Línea 93:		Línea 93:
	\|?Has Route=Route		\|?Has Route=Route
	\|?Has Population=Population		\|?Has Population=Population
	\|format=~~broadtable~~		\|format=table
	\|headers=plain		\|headers=plain
	\|mainlabel=-		\|mainlabel=-

Danbot: Add MedicationDose SMW query table for dynamic indications by condition

2026-03-20T20:36:39Z

Add MedicationDose SMW query table for dynamic indications by condition

@@ Línea 83: / Línea 83: @@
 *Excretion: urine
 *Mechanism of Action: modulates neuronal voltage-dependent Na and Ca channels
 ==See Also==

Elcatracho: /* See Also */

2021-02-10T16:03:25Z

ClaireLewis: /* References */

2019-09-22T20:03:03Z

References

← Revisión anterior		Revisión del 20:03 22 sep 2019
Línea 92:		Línea 92:

	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:Neurology]]

Rossdonaldson1: Text replacement - " phenytoin" to " phenytoin"

2016-08-03T08:13:11Z

Text replacement - " phenytoin" to " phenytoin"

← Revisión anterior		Revisión del 08:13 3 ago 2016
Línea 11:		Línea 11:
	**Initial Maintenance: 4-6mg/kg/day IV/IM		**Initial Maintenance: 4-6mg/kg/day IV/IM
	*Short-Term Substitution for PO Phenytoin		*Short-Term Substitution for PO Phenytoin
	**Can be substituted for PO phenytoin therapy at the same total daily dose		**Can be substituted for PO [[phenytoin]] therapy at the same total daily dose
	*Administration		*Administration
	**Maximum IV rate of 150mg PE/min		**Maximum IV rate of 150mg PE/min
	*Monitor: phenytoin level 2 hr after IV, 4 hr after IM		*Monitor: [[phenytoin]] level 2 hr after IV, 4 hr after IM
	*All dosing in mg "phenytoin equivalents" (PE); 75mg fosphenytoin equivalent to 50mg phenytoin		*All dosing in mg "phenytoin equivalents" (PE); 75mg fosphenytoin equivalent to 50mg [[phenytoin]]

	==Pediatric Dosing==		==Pediatric Dosing==
Línea 36:		Línea 36:
	*'''Black Box Warnings'''		*'''Black Box Warnings'''
	**Cardiovascular risk associated with rapid infusion rates		**Cardiovascular risk associated with rapid infusion rates
	**Risk of hypotension and arrhythmias with infusion rates that exceed 150mg/minute of phenytoin sodium equivalents (PE)		**Risk of hypotension and arrhythmias with infusion rates that exceed 150mg/minute of [[phenytoin]] sodium equivalents (PE)
	**Careful cardiac monitoring is needed during and after administering IV administration		**Careful cardiac monitoring is needed during and after administering IV administration
	**These events have also been reported at or below 150mg/minute		**These events have also been reported at or below 150mg/minute
Línea 80:		Línea 80:
	==Pharmacology==		==Pharmacology==
	*Half-life: 15 min (phenytoin)		*Half-life: 15 min (phenytoin)
	*Metabolism: CYP450; prodrug metabolized to phenytoin		*Metabolism: CYP450; prodrug metabolized to [[phenytoin]]
	*Excretion: urine		*Excretion: urine
	*Mechanism of Action: modulates neuronal voltage-dependent Na and Ca channels		*Mechanism of Action: modulates neuronal voltage-dependent Na and Ca channels

Neil.m.young: Text replacement - "6 mg" to "6mg"

2016-07-19T07:08:25Z

Text replacement - "6 mg" to "6mg"

← Revisión anterior		Revisión del 07:08 19 jul 2016
Línea 9:		Línea 9:
	*Nonemergent Seizure		*Nonemergent Seizure
	**Load: 10-20mg/kg IV/IM		**Load: 10-20mg/kg IV/IM
	**Initial Maintenance: 4-~~6 mg~~/kg/day IV/IM		**Initial Maintenance: 4-6mg/kg/day IV/IM
	*Short-Term Substitution for PO Phenytoin		*Short-Term Substitution for PO Phenytoin
	**Can be substituted for PO phenytoin therapy at the same total daily dose		**Can be substituted for PO phenytoin therapy at the same total daily dose

Neil.m.young: Text replacement - "0 mg" to "0mg"

2016-07-19T04:29:27Z

Text replacement - "0 mg" to "0mg"

← Revisión anterior		Revisión del 04:29 19 jul 2016
Línea 6:		Línea 6:
	==Adult Dosing==		==Adult Dosing==
	*Generalized Convulsive Status Epilepticus		*Generalized Convulsive Status Epilepticus
	**15-~~20 mg~~/kg IV, infuse at 100-~~150 mg~~/min		**15-20mg/kg IV, infuse at 100-150mg/min
	*Nonemergent Seizure		*Nonemergent Seizure
	**Load: 10-~~20 mg~~/kg IV/IM		**Load: 10-20mg/kg IV/IM
	**Initial Maintenance: 4-6 mg/kg/day IV/IM		**Initial Maintenance: 4-6 mg/kg/day IV/IM
	*Short-Term Substitution for PO Phenytoin		*Short-Term Substitution for PO Phenytoin
	**Can be substituted for PO phenytoin therapy at the same total daily dose		**Can be substituted for PO phenytoin therapy at the same total daily dose
	*Administration		*Administration
	**Maximum IV rate of ~~150 mg~~ PE/min		**Maximum IV rate of 150mg PE/min
	*Monitor: phenytoin level 2 hr after IV, 4 hr after IM		*Monitor: phenytoin level 2 hr after IV, 4 hr after IM
	*All dosing in mg "phenytoin equivalents" (PE); 75mg fosphenytoin equivalent to ~~50 mg~~ phenytoin		*All dosing in mg "phenytoin equivalents" (PE); 75mg fosphenytoin equivalent to 50mg phenytoin

	==Pediatric Dosing==		==Pediatric Dosing==
Línea 36:		Línea 36:
	*'''Black Box Warnings'''		*'''Black Box Warnings'''
	**Cardiovascular risk associated with rapid infusion rates		**Cardiovascular risk associated with rapid infusion rates
	**Risk of hypotension and arrhythmias with infusion rates that exceed ~~150 mg~~/minute of phenytoin sodium equivalents (PE)		**Risk of hypotension and arrhythmias with infusion rates that exceed 150mg/minute of phenytoin sodium equivalents (PE)
	**Careful cardiac monitoring is needed during and after administering IV administration		**Careful cardiac monitoring is needed during and after administering IV administration
	**These events have also been reported at or below ~~150 mg~~/minute		**These events have also been reported at or below 150mg/minute
	**Reduce infusion rate or discontinuation may be needed		**Reduce infusion rate or discontinuation may be needed
	*Cardiovascular collapse		*Cardiovascular collapse

Neil.m.young: Text replacement - "5 mg" to "5mg"

2016-07-18T23:41:32Z

Text replacement - "5 mg" to "5mg"

← Revisión anterior		Revisión del 23:41 18 jul 2016
Línea 15:		Línea 15:
	**Maximum IV rate of 150 mg PE/min		**Maximum IV rate of 150 mg PE/min
	*Monitor: phenytoin level 2 hr after IV, 4 hr after IM		*Monitor: phenytoin level 2 hr after IV, 4 hr after IM
	*All dosing in mg "phenytoin equivalents" (PE); ~~75 mg~~ fosphenytoin equivalent to 50 mg phenytoin		*All dosing in mg "phenytoin equivalents" (PE); 75mg fosphenytoin equivalent to 50 mg phenytoin

	==Pediatric Dosing==		==Pediatric Dosing==

Neil.m.young: Text replacement - "rxn" to "reaction"

2016-07-03T11:06:34Z

Text replacement - "rxn" to "reaction"

← Revisión anterior		Revisión del 11:06 3 jul 2016
Línea 74:		Línea 74:
	*Taste changes		*Taste changes
	*Fever		*Fever
	*Injection site ~~rxn~~		*Injection site reaction
	*Constipation		*Constipation
	*Hypokalemia		*Hypokalemia

← Revisión anterior		Revisión del 16:03 10 feb 2021
Línea 87:		Línea 87:
	*[[Anticonvulsants]]		*[[Anticonvulsants]]
	*[[Seizure levels and reloading]]		*[[Seizure levels and reloading]]
			*[[Phenytoin]]

	==References==		==References==