Doripenem - Revision history

Danbot: Add AntibioticDose SMW query table for dynamic indications by disease

2026-03-20T20:38:11Z

Add AntibioticDose SMW query table for dynamic indications by disease

@@ Línea 11: / Línea 11: @@
 ===[[Anthrax]], systemic===
 *500mg IV q8h for at least 2 wk as part of multi-drug regimen
 ==Pediatric Dosing==
 ===[[Anthrax]], systemic===
 *Neonates >32 weeks gestation

Ostermayer: /* Antibiotic SensitivitiesSanford Guide to Antimicrobial Therapy 2014 */

2025-07-19T19:21:52Z

Antibiotic SensitivitiesSanford Guide to Antimicrobial Therapy 2014

← Revisión anterior		Revisión del 19:21 19 jul 2025
Línea 115:		Línea 115:
	\| \|\|[[Klebsiella]] sp\|\|'''S'''		\| \|\|[[Klebsiella]] sp\|\|'''S'''
	\|-		\|-
	\| \|\|E. coli/Klebsiella ESBL+\|\|'''S'''		\| \|\|E. coli/Klebsiella ESBL+\|\|'''[[Has ESBL::S]]'''
	\|-		\|-
	\| \|\|E coli/Klebsiella KPC+\|\|R		\| \|\|E coli/Klebsiella KPC+\|\|R

Ostermayer at 18:21, 18 July 2025

2025-07-18T18:21:56Z

← Revisión anterior		Revisión del 18:21 18 jul 2025
Línea 149:		Línea 149:
	\| \|\|[[Acinetobacter sp.]]\|\|I		\| \|\|[[Acinetobacter sp.]]\|\|I
	\|-		\|-
	\| \|\|[[Pseudomonas aeruginosa]]\|\|'''[[Has ~~AntiPseudomonal~~::S]]'''		\| \|\|[[Pseudomonas aeruginosa]]\|\|'''[[Has Antipseudomonal::S]]'''
	\|-		\|-
	\| \|\|[[Burkholderia cepacia]]\|\|I		\| \|\|[[Burkholderia cepacia]]\|\|I

Ostermayer at 18:21, 18 July 2025

2025-07-18T18:21:14Z

← Revisión anterior		Revisión del 18:21 18 jul 2025
Línea 149:		Línea 149:
	\| \|\|[[Acinetobacter sp.]]\|\|I		\| \|\|[[Acinetobacter sp.]]\|\|I
	\|-		\|-
	\| \|\|[[Pseudomonas aeruginosa]]\|\|'''S'''		\| \|\|[[Pseudomonas aeruginosa]]\|\|'''[[Has AntiPseudomonal::S]]'''
	\|-		\|-
	\| \|\|[[Burkholderia cepacia]]\|\|I		\| \|\|[[Burkholderia cepacia]]\|\|I

Ostermayer at 17:09, 18 July 2025

2025-07-18T17:09:13Z

← Revisión anterior		Revisión del 17:09 18 jul 2025
Línea 1:		Línea 1:
	==General==		==General==
	*Type: [[~~Carbapenem~~]] (broad-spectrum beta-lactamase)		*Type: [[Is DrugClass::Carbapenems]] (broad-spectrum beta-lactamase)
	*Dosage Forms: IV		*Dosage Forms: IV
	*Common Trade Names: Doribax		*Common Trade Names: Doribax

ClaireLewis at 18:17, 22 September 2019

2019-09-22T18:17:34Z

← Revisión anterior		Revisión del 18:17 22 sep 2019
Línea 1:		Línea 1:
	==General==		==General==
	*Type: Carbapenem (broad-spectrum beta-lactamase)		*Type: [[Carbapenem]] (broad-spectrum beta-lactamase)
	*Dosage Forms: IV		*Dosage Forms: IV
	*Common Trade Names: Doribax		*Common Trade Names: Doribax
Línea 201:		Línea 201:

	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:ID]]

Jonwarren: Dosing, Pharmacology, Adverse Reactions

2017-09-20T17:14:22Z

Dosing, Pharmacology, Adverse Reactions

← Revisión anterior		Revisión del 17:14 20 sep 2017
Línea 5:		Línea 5:

	==Adult Dosing==		==Adult Dosing==
			===Intra-abdominal [[infection]], complicated===
			*500mg IV q8h x5-14 days
			===[[UTI]], complicated===
			*500mg IV q8h x10 days
			===[[Anthrax]], systemic===
			*500mg IV q8h for at least 2 wk as part of multi-drug regimen

	==Pediatric Dosing==		==Pediatric Dosing==
			===[[Anthrax]], systemic===
			*Neonates >32 weeks gestation
			**20-30 mg/kg/day IV divided q8-12h for two weeks as part of multi-drug regimen
			*1+ month old
			**120 mg/kg/day IV divided q8h for at least two weeks as part of multi-drug regimen
			***Max: 1 g/dose

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]:		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: B
	*Lactation:		*Lactation: May use while breastfeeding
	*Renal Dosing		*Renal Dosing
	**Adult		**Adult
			***CrCl 30-50: 250mg IV q8h
			***CrCl 10-30: 250mg IV q12h
			***CrCl <10: Not defined
			***HD: Not defined
	**Pediatric		**Pediatric
			***May be required, but specifics not defined
	*Hepatic Dosing		*Hepatic Dosing
	**Adult		**Adult
			***No adjustment
	**Pediatric		**Pediatric
			***May be required, but specifics not defined

	==Contraindications==		==Contraindications==
	*Allergy to class/drug		*Allergy to class/drug
			*Anaphylactic reaction to [[beta-lactams]]
			*Inhalational use
			*Ventilator-associated [[pneumonia]]
			*Caution:
			**Hypersensitivity to [[beta-lactams]]
			**Hypersensitivity to multiple allergens
			**Renal impairment
			**CNS disorder
			**[[Seizure]] history or risk
			**Recent abx-associated colitis

	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
			*Hypersensitivity Reaction
			*[[Anaphylaxis]]
			*[[Stevens-Johnson Syndrome]], Toxic epidermal necrolysis
			*[[Seizures]]
			*C. diff associated [[diarrhea]]
			*[[Pneumonia]], interstitial

	===Common===		===Common===
			*[[Headache]]
			*[[Nausea]], [[Diarrhea]]
			*[[Anemia]]
			*[[Phlebitis]], [[rash]], [[pruritus]]
			*ALT, AST Elevation
			*[[Candidiasis]], vuvlovaginal

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 1h
	*Metabolism:		*Metabolism: Kidney minimally
	*Excretion:		*Excretion: Urine 85% (70% unchanged), feces <1%
	*Mechanism of Action:		*Mechanism of Action: Inhibits cell wall synthesis

	==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==		==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==

Mholtz at 23:01, 30 August 2017

2017-08-30T23:01:49Z

← Revisión anterior		Revisión del 23:01 30 ago 2017
Línea 1:		Línea 1:
	==General==		==General==
	*Type:		*Type: Carbapenem (broad-spectrum beta-lactamase)
	*Dosage Forms:		*Dosage Forms: IV
	*Common Trade Names:		*Common Trade Names: Doribax

	==Adult Dosing==		==Adult Dosing==
Línea 153:		Línea 153:
	===Key===		===Key===
	{{Template:Antibacterial Spectra Key}}		{{Template:Antibacterial Spectra Key}}

	==See Also==		==See Also==

	==~~Source~~==		==References==

	<references/>		<references/>

	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Ostermayer: Text replacement - "Category:Drugs" to "Category:Pharmacology"

2016-03-22T15:54:49Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"

← Revisión anterior		Revisión del 15:54 22 mar 2016
Línea 159:		Línea 159:
	<references/>		<references/>

	[[Category:~~Drugs~~]]		[[Category:Pharmacology]]

Rossdonaldson1 at 00:58, 19 September 2014

2014-09-19T00:58:06Z

← Revisión anterior		Revisión del 00:58 19 sep 2014
Línea 158:		Línea 158:

	<references/>		<references/>

			[[Category:Drugs]]