Diphenhydramine - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:55:37Z

Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T17:26:26Z

Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

2026-03-20T16:44:36Z

Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

@@ Línea 56: / Línea 56: @@
 *Excretion: Urine
 *Mechanism of Action: [[Antihistamines]] / H1 blocker
 ==See Also==

2021-03-07T22:29:20Z

2019-09-01T12:18:00Z

Serious

← Revisión anterior		Revisión del 12:18 1 sep 2019
Línea 43:		Línea 43:
	*CNS depression		*CNS depression
	*Cardiac arrthymias (Sodium channel blockade)		*Cardiac arrthymias (Sodium channel blockade)
			*[[Seizures]]

	===Common===		===Common===

2018-11-09T02:55:33Z

Adult Dosing

← Revisión anterior		Revisión del 02:55 9 nov 2018
Línea 12:		Línea 12:
	**IM/IV: 10-50mg/dose		**IM/IV: 10-50mg/dose
	*[[Insomnia]]: 50mg PO qhs		*[[Insomnia]]: 50mg PO qhs
	*Injectable 1% diphenhydramine (10 mg/mL) can be used as an alternative to ester/amide anesthetics<ref>Pavlidakey PG et al. Diphenhydramine as an Alternative Local Anesthetic Agent. J Clin Aesthet Dermatol. 2009 Oct; 2(10): 37–40.</ref>		*Injectable 1% diphenhydramine (10 mg/mL) can be used as a local anesthestic alternative to ester/amide anesthetics<ref>Pavlidakey PG et al. Diphenhydramine as an Alternative Local Anesthetic Agent. J Clin Aesthet Dermatol. 2009 Oct; 2(10): 37–40.</ref>
	**Sodium channel blocker mechanism		**Sodium channel blocker mechanism
	**1-2 mL of 1% diphenhydramine at a time, to not exceed excessive sedation dose		**1-2 mL of 1% diphenhydramine at a time, to not exceed excessive sedation dose
Línea 19:		Línea 19:
	***Add 10 mL of 50 mg/mL diphenhydramine to 40 mL of NS		***Add 10 mL of 50 mg/mL diphenhydramine to 40 mL of NS
	***Sedation is dose related and is similar to what would be expected for IM doses		***Sedation is dose related and is similar to what would be expected for IM doses
			***Relative contraindications are the same for IM diphenhydramine administration

	==Pediatric Dosing==		==Pediatric Dosing==

2018-11-09T02:53:51Z

Adult Dosing

← Revisión anterior		Revisión del 02:53 9 nov 2018
Línea 16:		Línea 16:
	**1-2 mL of 1% diphenhydramine at a time, to not exceed excessive sedation dose		**1-2 mL of 1% diphenhydramine at a time, to not exceed excessive sedation dose
	**Typical vial is 50 mg/mL, so to make 10 mg/mL:		**Typical vial is 50 mg/mL, so to make 10 mg/mL:

	***10 mL NS removed from 50 mL vial		***10 mL NS removed from 50 mL vial

	***Add 10 mL of 50 mg/mL diphenhydramine to 40 mL of NS		***Add 10 mL of 50 mg/mL diphenhydramine to 40 mL of NS
	***Sedation is dose related and is similar to what would be expected for IM doses		***Sedation is dose related and is similar to what would be expected for IM doses

2018-11-09T02:53:29Z

Adult Dosing

← Revisión anterior		Revisión del 02:53 9 nov 2018
Línea 12:		Línea 12:
	**IM/IV: 10-50mg/dose		**IM/IV: 10-50mg/dose
	*[[Insomnia]]: 50mg PO qhs		*[[Insomnia]]: 50mg PO qhs
			*Injectable 1% diphenhydramine (10 mg/mL) can be used as an alternative to ester/amide anesthetics<ref>Pavlidakey PG et al. Diphenhydramine as an Alternative Local Anesthetic Agent. J Clin Aesthet Dermatol. 2009 Oct; 2(10): 37–40.</ref>
			**Sodium channel blocker mechanism
			**1-2 mL of 1% diphenhydramine at a time, to not exceed excessive sedation dose
			**Typical vial is 50 mg/mL, so to make 10 mg/mL:

			***10 mL NS removed from 50 mL vial

			***Add 10 mL of 50 mg/mL diphenhydramine to 40 mL of NS
			***Sedation is dose related and is similar to what would be expected for IM doses

	==Pediatric Dosing==		==Pediatric Dosing==

2017-07-07T08:50:10Z

Text replacement - "qid" to "QID"

2017-04-14T22:50:29Z

Adverse Reactions

← Revisión anterior		Revisión del 22:50 14 abr 2017
Línea 34:		Línea 34:
	*[[Anticholinergic toxicity]]		*[[Anticholinergic toxicity]]
	*CNS depression		*CNS depression
			*Cardiac arrthymias (Sodium channel blockade)

	===Common===		===Common===