Clofazimine - Revision history

ClaireLewis: /* References */

2019-09-20T17:40:35Z

References

← Revisión anterior		Revisión del 17:40 20 sep 2019
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	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:ID]]

Fletc151: /* References */

2019-06-13T14:22:09Z

References

@@ Línea 71: / Línea 71: @@
 ==References==
 <references/>
 [[Category:Pharmacology]]

ClaireLewis at 20:51, 31 August 2017

2017-08-31T20:51:31Z

← Revisión anterior		Revisión del 20:51 31 ago 2017
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	==Administration==		==Administration==
	*Type: ~~Antibacterial~~		*Type: [[Antibiotic]]
	*Dosage Forms: CAP 50mg		*Dosage Forms: CAP 50mg
	*Routes of Administration: Oral		*Routes of Administration: Oral
Línea 6:		Línea 6:

	==Adult Dosing==		==Adult Dosing==
	===Hansen disease, ~~mutlibacillary~~===		===[[Hansen's disease]], multibacillary===
	*50mg PO qd x 12mo in combination with [[rifampin]] and [[dapsone]]		*50mg PO qd x 12mo in combination with [[rifampin]] and [[dapsone]]
	**Give 300mg PO qmo x 12mo in addition to daily dose		**Give 300mg PO qmo x 12mo in addition to daily dose
Línea 14:		Línea 14:

	==Pediatric Dosing==		==Pediatric Dosing==
	===Hansen disease, ~~mutlibacillary~~===		===[[Hansen's disease]], multibacillary===
	*10-14 yo		*10-14 yo: 50mg PO qod AND 150mg PO qmo x12mo in combination with [[rifampin]] and [[dapsone]]
	**50mg PO qod AND 150mg PO qmo x12mo in combination with [[rifampin]] and [[dapsone]]		*>15 yo: 50mg PO qd AND 300mg PO qmo x 12mo in combination with [[rifampin]] and [[dapsone]]
	*15+ yo
	**50mg PO qd AND 300mg PO qmo x 12mo in combination with [[rifampin]] and [[dapsone]]

	==Special Populations==		==Special Populations==
	*[[Drug pregnancy categories\|Pregnancy Rating]]: ~~Caution of use during pregnancy; obtain negative pregnancy test before starting~~		*[[Drug pregnancy categories\|Pregnancy Rating]]: C
	*Lactation risk: Caution advised		*Lactation risk: Caution advised
	~~===~~Renal ~~Dosing===~~		*Renal dosing: not defined
	*Adult: ~~Not~~ defined		*Hepatic dosing: not defined
	*~~Pediatric: Not defined~~
	~~===~~Hepatic ~~Dosing===~~
	*Adult: Not defined
	*Pediatric: ~~Not~~ defined

	==Contraindications==		==Contraindications==
Línea 34:		Línea 28:
	*Caution:		*Caution:
	**Electrolyte abnormality		**Electrolyte abnormality
	**Congenital long QT syndrome		**Congenital long QT syndrome, [[QT prolongation]] or family history of long QT
	**[[QT prolongation]] or family history		**[[Torsades de pointes]], ventricular arrhythmias
	**[[Torsades de pointes]]
	**Ventricular arrhythmias
	**Bradycardia		**Bradycardia
	**Recent MI		**Recent MI
Línea 45:		Línea 37:
	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
	*~~Abdominal sx, severe~~		*Severe abdominal symptoms
	*[[Hepatitis]]		*[[Hepatitis]], [[Jaundice]]
	*[[Jaundice]]
	*Intestinal obstruction		*Intestinal obstruction
	*[[GI Bleeding]]		*[[GI Bleeding]]
	*Splenic infarction		*Splenic infarction
	*[[Thromboembolism]]		*[[Thromboembolism]]
	*[[QT Prolongation]]		*[[QT Prolongation]], [[Torsades de pointes]]
	*[[Torsades de pointes]]

	===Common===		===Common===
	*Skin discoloration		*Skin discoloration
	*[[Nausea]]/[[Vomiting]]		*[[Nausea]]/[[Vomiting]], [[diarrhea]], abdominal/epigastric pain
	*[[~~Diarrhea~~]]
	*Abdominal/epigastric pain
	*Ichthyosis/xeroderma		*Ichthyosis/xeroderma
	*[[Pruritus]]/rash		*[[Pruritus]]/rash
	*Discolored urine/feces/sputum/sweat		*Discolored urine/feces/sputum/sweat
	*Ocular pigmentation		*Ocular pigmentation, ocular irritation
	*Ocular irritation
	*[[Hyperglycemia]]		*[[Hyperglycemia]]
	*ESR elevated		*ESR elevated
Línea 81:		Línea 68:

	==See Also==		==See Also==
			*[[Hansen's disease]]

	==References==		==References==

Jonwarren: Creation

2017-08-25T15:48:48Z

Creation

Página nueva

==Administration==
*Type: Antibacterial
*Dosage Forms: CAP 50mg
*Routes of Administration: Oral
*Common Trade Names: Lamprene

==Adult Dosing==
===Hansen disease, mutlibacillary===
*50mg PO qd x 12mo in combination with [[rifampin]] and [[dapsone]]
**Give 300mg PO qmo x 12mo in addition to daily dose
===[[Erythema nodosum]] leprosum===
*100mg PO bid x12wk, then 100mg PO qd 12-24wk
**Start 100mg PO tid x12wek

==Pediatric Dosing==
===Hansen disease, mutlibacillary===
*10-14 yo
**50mg PO qod AND 150mg PO qmo x12mo in combination with [[rifampin]] and [[dapsone]]
*15+ yo
**50mg PO qd AND 300mg PO qmo x 12mo in combination with [[rifampin]] and [[dapsone]]

==Special Populations==
*[[Drug pregnancy categories|Pregnancy Rating]]: Caution of use during pregnancy; obtain negative pregnancy test before starting
*Lactation risk: Caution advised
===Renal Dosing===
*Adult: Not defined
*Pediatric: Not defined
===Hepatic Dosing===
*Adult: Not defined
*Pediatric: Not defined

==Contraindications==
*Allergy to class/drug
*Caution:
**Electrolyte abnormality
**Congenital long QT syndrome
**[[QT prolongation]] or family history
**[[Torsades de pointes]]
**Ventricular arrhythmias
**Bradycardia
**Recent MI
**[[CHF]]

==Adverse Reactions==
===Serious===
*Abdominal sx, severe
*[[Hepatitis]]
*[[Jaundice]]
*Intestinal obstruction
*[[GI Bleeding]]
*Splenic infarction
*[[Thromboembolism]]
*[[QT Prolongation]]
*[[Torsades de pointes]]

===Common===
*Skin discoloration
*[[Nausea]]/[[Vomiting]]
*[[Diarrhea]]
*Abdominal/epigastric pain
*Ichthyosis/xeroderma
*[[Pruritus]]/rash
*Discolored urine/feces/sputum/sweat
*Ocular pigmentation
*Ocular irritation
*[[Hyperglycemia]]
*ESR elevated

==Pharmacology==
*Half-life: 70 days
*Metabolism: Unknown
*Excretion: Feces primarily

==Mechanism of Action==
*Bacteriostatic or bactericidal: Binds to mycobacterial DNA, inhibiting growth

==Comments==

==See Also==

==References==
<references/>

[[Category:Pharmacology]]