Chlorpromazine - Revision history

Danbot: Add peer-reviewed reference

2026-03-22T10:16:45Z

Add peer-reviewed reference

← Revisión anterior		Revisión del 10:16 22 mar 2026
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	==Administration==		==Administration==
	*Type: [[Antipsychotic]], first generation		*Type: [[Antipsychotic]], first generation<ref>Leucht S, et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Lancet. 2013;382(9896):951-962. PMID 23810019</ref>
	*Dosage Forms: 25mg/mL IV solution; 25mg/5 mL oral solution; 10, 25, and 100mg tablets		*Dosage Forms: 25mg/mL IV solution; 25mg/5 mL oral solution; 10, 25, and 100mg tablets
	*Routes of Administration: PO, IM, IV		*Routes of Administration: PO, IM, IV

Elcatracho: /* Adverse Reactions */

2021-03-07T04:07:02Z

Adverse Reactions

← Revisión anterior		Revisión del 04:07 7 mar 2021
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	==Adverse Reactions==		==Adverse Reactions==
	*Extrapyramidal reactions (e.g., Parkinson-like symptoms, dystonia, akathisia, tardive dyskinesia), drowsiness, dizziness, skin reactions or rash, dry mouth, orthostatic hypotension, amenorrhea, galactorrhea, weight gain.		*Extrapyramidal reactions (e.g., Parkinson-like symptoms, dystonia, akathisia, tardive dyskinesia), drowsiness, dizziness, skin reactions or rash, dry mouth, orthostatic hypotension, amenorrhea, galactorrhea, weight gain.

			==See Also==
			*[[Antipsychotic toxicity]]

	==References==		==References==

ClaireLewis: /* References */

2019-09-20T01:42:58Z

References

← Revisión anterior		Revisión del 01:42 20 sep 2019
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	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:Psychiatry]]

Rossdonaldson1: /* Administration */

2016-07-30T03:41:44Z

Administration

← Revisión anterior		Revisión del 03:41 30 jul 2016
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	==Administration==		==Administration==
			*Type: [[Antipsychotic]], first generation
	*Dosage Forms: 25mg/mL IV solution; 25mg/5 mL oral solution; 10, 25, and 100mg tablets		*Dosage Forms: 25mg/mL IV solution; 25mg/5 mL oral solution; 10, 25, and 100mg tablets
	*Routes of Administration: PO, IM, IV		*Routes of Administration: PO, IM, IV

Neil.m.young: Text replacement - "2 mg" to "2mg"

2016-07-21T10:51:31Z

Text replacement - "2 mg" to "2mg"

← Revisión anterior		Revisión del 10:51 21 jul 2016
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	*Oral: 10 to 25mg every 4 to 6 hours as needed. May increase, if necessary.		*Oral: 10 to 25mg every 4 to 6 hours as needed. May increase, if necessary.
	*IM: 25mg one time. If no hypotension occurs, give 25 to 50mg every 3 to 4 hours as needed, then switch to oral dosage.		*IM: 25mg one time. If no hypotension occurs, give 25 to 50mg every 3 to 4 hours as needed, then switch to oral dosage.
	*IV: ~~2 mg~~ at 2 minute intervals. Do not exceed 25mg. Dilute to 1mg/mL.		*IV: 2mg at 2 minute intervals. Do not exceed 25mg. Dilute to 1mg/mL.

	===[[Hiccups]]===		===[[Hiccups]]===

Neil.m.young: Text replacement - "0 mg" to "0mg"

2016-07-20T22:01:19Z

Text replacement - "0 mg" to "0mg"

← Revisión anterior		Revisión del 22:01 20 jul 2016
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	==Administration==		==Administration==
	*Dosage Forms: 25mg/mL IV solution; 25mg/5 mL oral solution; 10, 25, and ~~100 mg~~ tablets		*Dosage Forms: 25mg/mL IV solution; 25mg/5 mL oral solution; 10, 25, and 100mg tablets
	*Routes of Administration: PO, IM, IV		*Routes of Administration: PO, IM, IV
	*Common Trade Names: Thorazine		*Common Trade Names: Thorazine
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	===[[Nausea/vomiting]]===		===[[Nausea/vomiting]]===
	*Oral: 10 to 25mg every 4 to 6 hours as needed. May increase, if necessary.		*Oral: 10 to 25mg every 4 to 6 hours as needed. May increase, if necessary.
	*IM: 25mg one time. If no hypotension occurs, give 25 to ~~50 mg~~ every 3 to 4 hours as needed, then switch to oral dosage.		*IM: 25mg one time. If no hypotension occurs, give 25 to 50mg every 3 to 4 hours as needed, then switch to oral dosage.
	*IV: 2 mg at 2 minute intervals. Do not exceed 25mg. Dilute to 1mg/mL.		*IV: 2 mg at 2 minute intervals. Do not exceed 25mg. Dilute to 1mg/mL.

	===[[Hiccups]]===		===[[Hiccups]]===
	*Oral: 25 to ~~50 mg~~ 3 to 4 times a day		*Oral: 25 to 50mg 3 to 4 times a day
	*IM: If symptoms persist for 2 to 3 days, give 25 to ~~50 mg~~ IM		*IM: If symptoms persist for 2 to 3 days, give 25 to 50mg IM
	*IV infusion: Should symptoms persist, use slow IV infusion: 25 to ~~50 mg~~ in 500 to 1000 mL of saline.		*IV infusion: Should symptoms persist, use slow IV infusion: 25 to 50mg in 500 to 1000 mL of saline.

	===[[Psychosis]]===		===[[Psychosis]]===
	*IM: Initial Dose 25 to ~~50 mg~~. The dose may be repeated in one hour. Subsequent doses may be increased and given every 2 to 4 hours as needed.		*IM: Initial Dose 25 to 50mg. The dose may be repeated in one hour. Subsequent doses may be increased and given every 2 to 4 hours as needed.
	*Oral: Initial Dose: 10 to 25mg orally 3 times a day. Total daily doses should be increased in 20 to ~~50 mg~~ increments every 3 or 4 days until symptoms are controlled.		*Oral: Initial Dose: 10 to 25mg orally 3 times a day. Total daily doses should be increased in 20 to 50mg increments every 3 or 4 days until symptoms are controlled.
	*Usual Maintenance Dose: ~~200 mg~~/day orally		*Usual Maintenance Dose: 200mg/day orally

	==Pediatric Dosing==		==Pediatric Dosing==
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	===Maximum recommended doses===		===Maximum recommended doses===
	*less than 5 years (less than 22.7 kg): ~~40 mg~~/day		*less than 5 years (less than 22.7 kg): 40mg/day
	*5 and older (22.7-45.5 kg): 75mg/day		*5 and older (22.7-45.5 kg): 75mg/day

Neil.m.young: Text replacement - "5 mg" to "5mg"

2016-07-19T10:49:25Z

Text replacement - "5 mg" to "5mg"

← Revisión anterior		Revisión del 10:49 19 jul 2016
Línea 1:		Línea 1:
	==Administration==		==Administration==
	*Dosage Forms: ~~25 mg~~/mL IV solution; ~~25 mg~~/5 mL oral solution; 10, 25, and 100 mg tablets		*Dosage Forms: 25mg/mL IV solution; 25mg/5 mL oral solution; 10, 25, and 100 mg tablets
	*Routes of Administration: PO, IM, IV		*Routes of Administration: PO, IM, IV
	*Common Trade Names: Thorazine		*Common Trade Names: Thorazine
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	==Adult Dosing==		==Adult Dosing==
	===[[Nausea/vomiting]]===		===[[Nausea/vomiting]]===
	*Oral: 10 to ~~25 mg~~ every 4 to 6 hours as needed. May increase, if necessary.		*Oral: 10 to 25mg every 4 to 6 hours as needed. May increase, if necessary.
	*IM: ~~25 mg~~ one time. If no hypotension occurs, give 25 to 50 mg every 3 to 4 hours as needed, then switch to oral dosage.		*IM: 25mg one time. If no hypotension occurs, give 25 to 50 mg every 3 to 4 hours as needed, then switch to oral dosage.
	*IV: 2 mg at 2 minute intervals. Do not exceed ~~25 mg~~. Dilute to 1mg/mL.		*IV: 2 mg at 2 minute intervals. Do not exceed 25mg. Dilute to 1mg/mL.

	===[[Hiccups]]===		===[[Hiccups]]===
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	===[[Psychosis]]===		===[[Psychosis]]===
	*IM: Initial Dose 25 to 50 mg. The dose may be repeated in one hour. Subsequent doses may be increased and given every 2 to 4 hours as needed.		*IM: Initial Dose 25 to 50 mg. The dose may be repeated in one hour. Subsequent doses may be increased and given every 2 to 4 hours as needed.
	*Oral: Initial Dose: 10 to ~~25 mg~~ orally 3 times a day. Total daily doses should be increased in 20 to 50 mg increments every 3 or 4 days until symptoms are controlled.		*Oral: Initial Dose: 10 to 25mg orally 3 times a day. Total daily doses should be increased in 20 to 50 mg increments every 3 or 4 days until symptoms are controlled.
	*Usual Maintenance Dose: 200 mg/day orally		*Usual Maintenance Dose: 200 mg/day orally

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	===Maximum recommended doses===		===Maximum recommended doses===
	*less than 5 years (less than 22.7 kg): 40 mg/day		*less than 5 years (less than 22.7 kg): 40 mg/day
	*5 and older (22.7-45.5 kg): ~~75 mg~~/day		*5 and older (22.7-45.5 kg): 75mg/day

	==Special Populations==		==Special Populations==

Neil.m.young: Text replacement - "1 mg" to "1mg"

2016-07-19T00:37:44Z

Text replacement - "1 mg" to "1mg"

← Revisión anterior		Revisión del 00:37 19 jul 2016
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	*Oral: 10 to 25 mg every 4 to 6 hours as needed. May increase, if necessary.		*Oral: 10 to 25 mg every 4 to 6 hours as needed. May increase, if necessary.
	*IM: 25 mg one time. If no hypotension occurs, give 25 to 50 mg every 3 to 4 hours as needed, then switch to oral dosage.		*IM: 25 mg one time. If no hypotension occurs, give 25 to 50 mg every 3 to 4 hours as needed, then switch to oral dosage.
	*IV: 2 mg at 2 minute intervals. Do not exceed 25 mg. Dilute to ~~1 mg~~/mL.		*IV: 2 mg at 2 minute intervals. Do not exceed 25 mg. Dilute to 1mg/mL.

	===[[Hiccups]]===		===[[Hiccups]]===
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	===[[Nausea/vomiting]]===		===[[Nausea/vomiting]]===
	*Oral: 0.5 to ~~1 mg~~/kg/dose every 4 to 6 hours as needed.		*Oral: 0.5 to 1mg/kg/dose every 4 to 6 hours as needed.
	*IM or IV: 0.5 to ~~1 mg~~/kg/dose every 6 to 8 hours		*IM or IV: 0.5 to 1mg/kg/dose every 6 to 8 hours

	===Maximum recommended doses===		===Maximum recommended doses===

Neil.m.young: Text replacement - "* " to "*"

2016-07-05T10:08:34Z

Text replacement - "* " to "*"

← Revisión anterior		Revisión del 10:08 5 jul 2016
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	==Adverse Reactions==		==Adverse Reactions==
	* Extrapyramidal reactions (e.g., Parkinson-like symptoms, dystonia, akathisia, tardive dyskinesia), drowsiness, dizziness, skin reactions or rash, dry mouth, orthostatic hypotension, amenorrhea, galactorrhea, weight gain.		*Extrapyramidal reactions (e.g., Parkinson-like symptoms, dystonia, akathisia, tardive dyskinesia), drowsiness, dizziness, skin reactions or rash, dry mouth, orthostatic hypotension, amenorrhea, galactorrhea, weight gain.

	==References==		==References==

Ostermayer: Text replacement - "Category:Drugs" to "Category:Pharmacology"

2016-03-22T15:54:31Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"

← Revisión anterior		Revisión del 15:54 22 mar 2016
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	#P Young. The ICU Drug Manual. ''Chlorpromazine''. Retrieved from http://lifeinthefastlane.com/book/critical-care-drugs/chlorpromazine/		#P Young. The ICU Drug Manual. ''Chlorpromazine''. Retrieved from http://lifeinthefastlane.com/book/critical-care-drugs/chlorpromazine/

	[[Category:~~Drugs~~]]		[[Category:Pharmacology]]