Cerebral edema in brain cancer - Revision history

ClaireLewis at 00:07, 1 October 2019

2019-10-01T00:07:05Z

← Revisión anterior		Revisión del 00:07 1 oct 2019
Línea 13:		Línea 13:
	*Findings:		*Findings:
	**[[Altered mental status]]		**[[Altered mental status]]
	**Extremity sensory/motor deficit		**Extremity [[numbness\|sensory]]/[[weakness\|motor deficit]]
	**[[Bradycardia]], elevated BP, irregular breathing		**[[Bradycardia]], [[hypertension\|elevated BP]], irregular breathing
	**EOM abnormalities		**EOM abnormalities
	**Pupillary size abnormalities		**Pupillary size abnormalities
	**Extensor plantar response		**Extensor plantar response
			**See also: [[Herniation Syndromes]]

	==Corticosteroids==		==[[Corticosteroids]]==
	*Reduce tumor capillary permeability, inflammatory cytotoxicity		*Reduce tumor capillary permeability, inflammatory cytotoxicity
	*[[Dexamethasone]] IV bolus 10-20mg on initial presentation<ref>Nahaczewski AE et al. Dexamethasone Therapy in Patients With Brain Tumors - A Focus on Tapering. J Neurosci Nurs. 2004;36(6):340-343.</ref>		*[[Dexamethasone]] IV bolus 10-20mg on initial presentation<ref>Nahaczewski AE et al. Dexamethasone Therapy in Patients With Brain Tumors - A Focus on Tapering. J Neurosci Nurs. 2004;36(6):340-343.</ref>
Línea 26:		Línea 27:
	**May see improvement within 12-48hrs		**May see improvement within 12-48hrs
	*Complications<ref>Dietric J et al. Corticosteroids in brain cancer patients: benefits and pitfalls. Expert Rev Clin Pharmacol. 2011 Mar; 4(2): 233–242.</ref>:		*Complications<ref>Dietric J et al. Corticosteroids in brain cancer patients: benefits and pitfalls. Expert Rev Clin Pharmacol. 2011 Mar; 4(2): 233–242.</ref>:
	**GI ~~bleeds~~ - ensure GI prophylaxis		**[[GI bleed]]s - ensure GI prophylaxis
	**Osteoporosis - avoid in pathologic fracture		**Osteoporosis - avoid in pathologic [[fracture]]
	**Neuropsychiatric - avoid in acute psychosis		**Neuropsychiatric - avoid in acute [[psychosis]]
	**Steroid myopathy - consider nonfluorinated steroids, such as [[prednisone]], over dexamethasone		**Steroid myopathy - consider nonfluorinated steroids, such as [[prednisone]], over dexamethasone

ClaireLewis: /* See Also */

2016-09-12T04:54:19Z

Rossdonaldson1: Text replacement - " prednisone" to " prednisone"

2016-08-03T09:23:31Z

Text replacement - " prednisone" to " prednisone"

← Revisión anterior		Revisión del 09:23 3 ago 2016
Línea 29:		Línea 29:
	**Osteoporosis - avoid in pathologic fracture		**Osteoporosis - avoid in pathologic fracture
	**Neuropsychiatric - avoid in acute psychosis		**Neuropsychiatric - avoid in acute psychosis
	**Steroid myopathy - consider nonfluorinated steroids, such as prednisone, over dexamethasone		**Steroid myopathy - consider nonfluorinated steroids, such as [[prednisone]], over dexamethasone

	==See Also==		==See Also==

Neil.m.young: Text replacement - "4 mg" to "4mg"

2016-07-19T02:59:11Z

Text replacement - "4 mg" to "4mg"

← Revisión anterior		Revisión del 02:59 19 jul 2016
Línea 22:		Línea 22:
	*Reduce tumor capillary permeability, inflammatory cytotoxicity		*Reduce tumor capillary permeability, inflammatory cytotoxicity
	*[[Dexamethasone]] IV bolus 10-20mg on initial presentation<ref>Nahaczewski AE et al. Dexamethasone Therapy in Patients With Brain Tumors - A Focus on Tapering. J Neurosci Nurs. 2004;36(6):340-343.</ref>		*[[Dexamethasone]] IV bolus 10-20mg on initial presentation<ref>Nahaczewski AE et al. Dexamethasone Therapy in Patients With Brain Tumors - A Focus on Tapering. J Neurosci Nurs. 2004;36(6):340-343.</ref>
	**Followed by ~~4 mg~~ IV q6hrs		**Followed by 4mg IV q6hrs
	**PO and IV dosing equivalent bioavailability		**PO and IV dosing equivalent bioavailability
	**May see improvement within 12-48hrs		**May see improvement within 12-48hrs

Neil.m.young: Text replacement - "0 mg" to "0mg"

2016-07-18T19:00:08Z

Text replacement - "0 mg" to "0mg"

← Revisión anterior		Revisión del 19:00 18 jul 2016
Línea 21:		Línea 21:
	==Corticosteroids==		==Corticosteroids==
	*Reduce tumor capillary permeability, inflammatory cytotoxicity		*Reduce tumor capillary permeability, inflammatory cytotoxicity
	*[[Dexamethasone]] IV bolus 10-~~20 mg~~ on initial presentation<ref>Nahaczewski AE et al. Dexamethasone Therapy in Patients With Brain Tumors - A Focus on Tapering. J Neurosci Nurs. 2004;36(6):340-343.</ref>		*[[Dexamethasone]] IV bolus 10-20mg on initial presentation<ref>Nahaczewski AE et al. Dexamethasone Therapy in Patients With Brain Tumors - A Focus on Tapering. J Neurosci Nurs. 2004;36(6):340-343.</ref>
	**Followed by 4 mg IV q6hrs		**Followed by 4 mg IV q6hrs
	**PO and IV dosing equivalent bioavailability		**PO and IV dosing equivalent bioavailability

ClaireLewis: /* Corticosteroids */

2016-07-14T23:00:02Z

Corticosteroids

← Revisión anterior		Revisión del 23:00 14 jul 2016
Línea 21:		Línea 21:
	==Corticosteroids==		==Corticosteroids==
	*Reduce tumor capillary permeability, inflammatory cytotoxicity		*Reduce tumor capillary permeability, inflammatory cytotoxicity
	*IV bolus 10-20 mg ~~dexamethasone~~ on initial presentation<ref>Nahaczewski AE et al. Dexamethasone Therapy in Patients With Brain Tumors - A Focus on Tapering. J Neurosci Nurs. 2004;36(6):340-343.</ref>		*[[Dexamethasone]] IV bolus 10-20 mg on initial presentation<ref>Nahaczewski AE et al. Dexamethasone Therapy in Patients With Brain Tumors - A Focus on Tapering. J Neurosci Nurs. 2004;36(6):340-343.</ref>
	**Followed by 4 mg IV q6hrs		**Followed by 4 mg IV q6hrs
	**PO and IV dosing equivalent bioavailability		**PO and IV dosing equivalent bioavailability

ClaireLewis: /* Clinical Features */

2016-07-14T22:59:24Z

Clinical Features

← Revisión anterior		Revisión del 22:59 14 jul 2016
Línea 12:		Línea 12:
	*Cerebral edema in itself does not produce neuro findings until ICP elevation causes ischemia<ref>Pollay M. Blood-Brain Barrier, Cerebral Edema. In : Wilkins RH, Rengachary SS, editors. Neurosurgery. 2nd ed. New York: Mc Graw Hill Book Co., 1996;335-44.</ref>		*Cerebral edema in itself does not produce neuro findings until ICP elevation causes ischemia<ref>Pollay M. Blood-Brain Barrier, Cerebral Edema. In : Wilkins RH, Rengachary SS, editors. Neurosurgery. 2nd ed. New York: Mc Graw Hill Book Co., 1996;335-44.</ref>
	*Findings:		*Findings:
	**~~AMS~~		**[[Altered mental status]]
	**Extremity sensory/motor deficit		**Extremity sensory/motor deficit
	**Bradycardia, elevated BP, irregular breathing		**[[Bradycardia]], elevated BP, irregular breathing
	**EOM abnormalities		**EOM abnormalities
	**Pupillary size abnormalities		**Pupillary size abnormalities

Rossdonaldson1: Text replacement - "fx" to "fracture"

2016-07-08T20:31:07Z

Text replacement - "fx" to "fracture"

← Revisión anterior		Revisión del 20:31 8 jul 2016
Línea 27:		Línea 27:
	*Complications<ref>Dietric J et al. Corticosteroids in brain cancer patients: benefits and pitfalls. Expert Rev Clin Pharmacol. 2011 Mar; 4(2): 233–242.</ref>:		*Complications<ref>Dietric J et al. Corticosteroids in brain cancer patients: benefits and pitfalls. Expert Rev Clin Pharmacol. 2011 Mar; 4(2): 233–242.</ref>:
	**GI bleeds - ensure GI prophylaxis		**GI bleeds - ensure GI prophylaxis
	**Osteoporosis - avoid in pathologic fx		**Osteoporosis - avoid in pathologic fracture
	**Neuropsychiatric - avoid in acute psychosis		**Neuropsychiatric - avoid in acute psychosis
	**Steroid myopathy - consider nonfluorinated steroids, such as prednisone, over dexamethasone		**Steroid myopathy - consider nonfluorinated steroids, such as prednisone, over dexamethasone

Neil.m.young: Text replacement - "==Sources==" to "==References=="

2016-06-27T02:39:06Z

Text replacement - "==Sources==" to "==References=="

← Revisión anterior		Revisión del 02:39 27 jun 2016
Línea 35:		Línea 35:
	*[[Corticosteroids]]		*[[Corticosteroids]]

	==~~Sources~~==		==References==
	<references/>		<references/>

	[[Category:Neurology]]		[[Category:Neurology]]
	[[Category:Heme/Onc]]		[[Category:Heme/Onc]]

Kxl328 at 19:44, 23 May 2016

2016-05-23T19:44:48Z

← Revisión anterior		Revisión del 19:44 23 may 2016
Línea 33:		Línea 33:
	==See Also==		==See Also==
	*[[Elevated intracranial pressure]]		*[[Elevated intracranial pressure]]
			*[[Corticosteroids]]

	==Sources==		==Sources==

← Revisión anterior		Revisión del 04:54 12 sep 2016
Línea 34:		Línea 34:
	*[[Elevated intracranial pressure]]		*[[Elevated intracranial pressure]]
	*[[Corticosteroids]]		*[[Corticosteroids]]
			*[[Brain tumor]]

	==References==		==References==