Ostermayer: Created page with "==General== Type: Is Generation::3rd generation Is DrugClass::Cephalosporin Dosage Forms: powder for injection, premixed frozen solution Dosage Strengths: 500mg, 1g, 2g; 1g/50mL, 2g/50mL Routes of Administration: IV, IM Common Trade Names: Cefizox ==Adult Dosing== ===General=== Uncomplicated: 500mg IM/IV q12h Moderate-Severe: 1-2g IM/IV q8-12h Life Threatening: 3-4g IV q8h Max: 12g/day ===UTI, Uncomplicated=== 500mg IM/IV q12h ===PID (Pelvic..."

2026-01-28T20:03:16Z

Created page with "==General== *Type: Is Generation::3rd generation Is DrugClass::Cephalosporin *Dosage Forms: powder for injection, premixed frozen solution *Dosage Strengths: 500mg, 1g, 2g; 1g/50mL, 2g/50mL *Routes of Administration: IV, IM *Common Trade Names: Cefizox ==Adult Dosing== ===General=== *Uncomplicated: 500mg IM/IV q12h *Moderate-Severe: 1-2g IM/IV q8-12h *Life Threatening: 3-4g IV q8h *Max: 12g/day ===UTI, Uncomplicated=== *500mg IM/IV q12h ===PID (Pelvic..."

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==General==
*Type: [[Is Generation::3rd generation]] [[Is DrugClass::Cephalosporin]]
*Dosage Forms: powder for injection, premixed frozen solution
*Dosage Strengths: 500mg, 1g, 2g; 1g/50mL, 2g/50mL
*Routes of Administration: IV, IM
*Common Trade Names: Cefizox

==Adult Dosing==
===General===
*Uncomplicated: 500mg IM/IV q12h
*Moderate-Severe: 1-2g IM/IV q8-12h
*Life Threatening: 3-4g IV q8h
*Max: 12g/day

===[[UTI]], Uncomplicated===
*500mg IM/IV q12h

===[[PID]] (Pelvic Inflammatory Disease)===
*2g IV q8h (often used in combination with doxycycline)

===[[Gonorrhea]], Uncomplicated===
*500mg IM x1

==Pediatric Dosing==
===General (>6 Months)===
*50mg/kg/dose IM/IV q6-8h
*Max: 200mg/kg/day (not to exceed adult maximum)

==Special Populations==
*Pregnancy: B
*Lactation: Excreted in breast milk; use with caution
*Renal
**Adult
***CrCl 50-79: 500mg-1.5g q8h
***CrCl 5-49: 250mg-1g q12h
***CrCl <5: 500mg q48h or 250mg q24h
***Hemodialysis: give supplement after dialysis
***Peritoneal dialysis: see CrCl <5
**Pediatric
***Renal impairment requires adjustment; follow adult proportions based on GFR
*Hepatic
**No adjustment defined

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*[[Stevens-Johnson Syndrome]]
*[[Clostridium difficile]]
*Pseudomembranous colitis
*Hemolytic anemia
*[[Seizures]]

===Common===
*[[Diarrhea]]
*[[Rash]] / Pruritus
*[[Nausea and Vomiting]]
*Injection site pain/phlebitis
*Eosinophilia
*Thrombocytosis
*Elevated Transaminases

==Pharmacology==
*Half-life: 1.7h
*Metabolism: Not metabolized
*Excretion: Urine (Unchanged)
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis.
*Note: Notable among 3rd generation cephalosporins for having some activity against anaerobes (B. fragilis).

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||'''S'''
|-
| ||[[N. meningitidis]]||'''S'''
|-
| ||[[Moraxella catarrhalis]]||'''S'''
|-
| ||[[H. influenzae]]||'''S'''
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||I
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||'''S'''
|-
| ||Serratia marcescens||'''S'''
|-
| ||[[Salmonella]] sp||'''S'''
|-
| ||[[Shigella]] sp||'''S'''
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||'''S'''
|-
| ||[[Providencia sp.]]||'''S'''
|-
| ||[[Morganella sp.]]||'''S'''
|-
| ||[[Citrobacter freundii]]||I
|-
| ||[[Citrobacter diversus]]||'''S'''
|-
| ||[[Citrobacter sp.]]||I
|-
| ||[[Aeromonas sp]]||'''S'''
|-
| ||[[Acinetobacter sp.]]||R
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||'''S'''
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||'''S'''
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||R
|-
| ||[[Mycoplasm pneumoniae]]||R
|-
| ||[[Rickettsia sp]]||R
|-
| ||[[Mycobacterium avium]]||R
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||I
|-
| ||[[Prevotella melaninogenica]]||'''S'''
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||'''S'''
|-
| ||[[Fusobacterium necrophorum]]||'''S'''
|-
| ||[[Peptostreptococcus sp.]]||'''S'''
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]

Ceftizoxime - Revision history