Ostermayer: Created page with "==General== Type: Is Generation::1st generation Is DrugClass::Cephalosporin Dosage Forms: Capsules, Oral Suspension, Powder for injection Dosage Strengths: 250mg, 500mg; 125mg/5ml, 250mg/5ml; 500mg, 1g vials Routes of Administration: PO, IV, IM Common Trade Names: Velosef, Nicef ==Adult Dosing== ===General=== Mild: 250-500mg PO q6h or 500mg-1g PO q12h Mod-Severe: 500mg-1g IM/IV q6h Max: 8g/day (IV), 4g/day (PO) ===UTI, Uncomplicated=== *500mg PO q12..."

2026-01-27T17:38:19Z

Created page with "==General== *Type: Is Generation::1st generation Is DrugClass::Cephalosporin *Dosage Forms: Capsules, Oral Suspension, Powder for injection *Dosage Strengths: 250mg, 500mg; 125mg/5ml, 250mg/5ml; 500mg, 1g vials *Routes of Administration: PO, IV, IM *Common Trade Names: Velosef, Nicef ==Adult Dosing== ===General=== *Mild: 250-500mg PO q6h or 500mg-1g PO q12h *Mod-Severe: 500mg-1g IM/IV q6h *Max: 8g/day (IV), 4g/day (PO) ===UTI, Uncomplicated=== *500mg PO q12..."

Página nueva

==General==
*Type: [[Is Generation::1st generation]] [[Is DrugClass::Cephalosporin]]
*Dosage Forms: Capsules, Oral Suspension, Powder for injection
*Dosage Strengths: 250mg, 500mg; 125mg/5ml, 250mg/5ml; 500mg, 1g vials
*Routes of Administration: PO, IV, IM
*Common Trade Names: Velosef, Nicef

==Adult Dosing==
===General===
*Mild: 250-500mg PO q6h or 500mg-1g PO q12h
*Mod-Severe: 500mg-1g IM/IV q6h
*Max: 8g/day (IV), 4g/day (PO)

===[[UTI]], Uncomplicated===
*500mg PO q12h

===Respiratory Tract Infections===
*250mg PO q6h or 500mg PO q12h

===Skin and Soft Tissue===
*250mg PO q6h or 500mg PO q12h

===Surgical Prophylaxis===
*1-2g IM/IV x1 (30-90 min before procedure)
*May repeat q4-6h for up to 24h

==Pediatric Dosing==
===General (>9 Months)===
*25-50mg/kg/day PO/IM/IV divided q6h or q12h
*Severe: 75-100mg/kg/day PO/IM/IV divided q6h
*Max: 4g/day

==Special Populations==
*Pregnancy: B
*Lactation: Excreted in breast milk; use with caution
*Renal
**Adult
***CrCl >20: dose unchanged
***CrCl 5-20: 250-500mg q6h (PO) or 50% of dose (IV)
***CrCl <5: 250-500mg q12h (PO) or 25% of dose (IV)
***Hemodialysis: Give dose after dialysis (250mg start, then 250mg q12h)
***Peritoneal dialysis: Resistant to dialysis
**Pediatric
***Renal dosing adjustment required; specific guidelines vary, generally increase interval
*Hepatic
**Not defined

==Contraindications==
*Allergy to class/drug (Cephalosporins)
*Immediate hypersensitivity to Penicillins

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*[[Stevens-Johnson Syndrome]]
*[[Neutropenia]]
*[[Thrombocytopenia]]
*[[Clostridium difficile]]
*Nephrotoxicity (rare)
*[[Seizures]] (in renal impairment)

===Common===
*[[Diarrhea]]
*[[Nausea and Vomiting]]
*[[Rash]]
*[[Abdominal Pain]]
*Urticaria
*Pruritus
*Transient rise in BUN/Creatinine

==Pharmacology==
*Half-life: 0.7 - 1.3h (Extended in renal failure)
*Metabolism: Not significantly metabolized
*Excretion: Urine (>90% unchanged)
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||I
|-
| ||[[N. meningitidis]]||R
|-
| ||[[Moraxella catarrhalis]]||I
|-
| ||[[H. influenzae]]||I
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||R
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||R
|-
| ||Serratia marcescens||R
|-
| ||[[Salmonella]] sp||X1
|-
| ||[[Shigella]] sp||X1
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||R
|-
| ||[[Providencia sp.]]||R
|-
| ||[[Morganella sp.]]||R
|-
| ||[[Citrobacter freundii]]||R
|-
| ||[[Citrobacter diversus]]||R
|-
| ||[[Citrobacter sp.]]||R
|-
| ||[[Aeromonas sp]]||R
|-
| ||[[Acinetobacter sp.]]||R
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||R
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||X1
|-
| ||[[Haemophilus ducreyi]]||R
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||R
|-
| ||[[Mycoplasm pneumoniae]]||R
|-
| ||[[Rickettsia sp]]||R
|-
| ||[[Mycobacterium avium]]||R
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||R
|-
| ||[[Prevotella melaninogenica]]||X1
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||I
|-
| ||[[Fusobacterium necrophorum]]||X1
|-
| ||[[Peptostreptococcus sp.]]||'''S'''
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]
*[[Cephalosporins]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]

Cefradine - Revision history