Ostermayer: Created page with "==General== Type: Is Generation::3rd generation Is DrugClass::Cephalosporin Dosage Forms: powder for injection Dosage Strengths: 0.5g, 1g, 2g Routes of Administration: IV, IM Common Trade Names: Timecef, Kenicef ==Adult Dosing== ===General=== Standard: 1-2g IM/IV q24h (or divided q12h) Severe: 2-4g IM/IV divided q12h Max: 4g/day ===Lower Respiratory Tract Infection (Pneumonia)=== 1g IM/IV q12h OR 2g q24h ===UTI, Uncomplicated=== 1g IM/IV q24h..."

2026-01-28T19:39:03Z

Created page with "==General== *Type: Is Generation::3rd generation Is DrugClass::Cephalosporin *Dosage Forms: powder for injection *Dosage Strengths: 0.5g, 1g, 2g *Routes of Administration: IV, IM *Common Trade Names: Timecef, Kenicef ==Adult Dosing== ===General=== *Standard: 1-2g IM/IV q24h (or divided q12h) *Severe: 2-4g IM/IV divided q12h *Max: 4g/day ===Lower Respiratory Tract Infection (Pneumonia)=== *1g IM/IV q12h OR 2g q24h ===UTI, Uncomplicated=== *1g IM/IV q24h..."

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==General==
*Type: [[Is Generation::3rd generation]] [[Is DrugClass::Cephalosporin]]
*Dosage Forms: powder for injection
*Dosage Strengths: 0.5g, 1g, 2g
*Routes of Administration: IV, IM
*Common Trade Names: Timecef, Kenicef

==Adult Dosing==
===General===
*Standard: 1-2g IM/IV q24h (or divided q12h)
*Severe: 2-4g IM/IV divided q12h
*Max: 4g/day

===Lower Respiratory Tract Infection ([[Pneumonia]])===
*1g IM/IV q12h OR 2g q24h

===[[UTI]], Uncomplicated===
*1g IM/IV q24h
*Single dose therapy (stat dose) of 1-2g is also used

===[[Gonorrhea]]===
*0.25-0.5g IM x 1

==Pediatric Dosing==
===General===
*Safety in neonates not fully established
*Infants/Children: 50-100mg/kg/day IM/IV divided q12h or q24h
*Max: 4g/day

==Special Populations==
*Pregnancy: B
*Lactation: Excreted in breast milk; use with caution
*Renal
**Adult
***CrCl 10-30: 1g q24h via a loading dose
***CrCl <10: 0.5g q24h or 1g q48h
***Hemodialysis: Administer dose after dialysis
**Pediatric
***Adjust dosage interval based on degree of renal impairment (similar to adult proportions)
*Hepatic
**No adjustment necessary

==Contraindications==
*Allergy to class/drug (Cephalosporins)
*History of anaphylactic shock to Penicillin

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*[[Stevens-Johnson Syndrome]]
*[[Clostridium difficile]]
*Pseudomembranous colitis
*Hematologic abnormalities (eosinophilia, rarely leukopenia)

===Common===
*[[Diarrhea]]
*[[Nausea and Vomiting]]
*[[Rash]] / Pruritus
*Injection site pain/induration
*Transient elevation of liver enzymes (AST/ALT)

==Pharmacology==
*Half-life: ~4h
*Metabolism: Not metabolized
*Excretion: Urine (largely unchanged)
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis.
*Notes: Has been shown to possess immunomodulating activity (stimulates phagocytic functions of neutrophils and macrophages).

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||'''S'''
|-
| ||[[N. meningitidis]]||'''S'''
|-
| ||[[Moraxella catarrhalis]]||'''S'''
|-
| ||[[H. influenzae]]||'''S'''
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||I
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||I
|-
| ||Serratia marcescens||I
|-
| ||[[Salmonella]] sp||'''S'''
|-
| ||[[Shigella]] sp||'''S'''
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||'''S'''
|-
| ||[[Providencia sp.]]||'''S'''
|-
| ||[[Morganella sp.]]||'''S'''
|-
| ||[[Citrobacter freundii]]||I
|-
| ||[[Citrobacter diversus]]||'''S'''
|-
| ||[[Citrobacter sp.]]||I
|-
| ||[[Aeromonas sp]]||'''S'''
|-
| ||[[Acinetobacter sp.]]||R
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||'''S'''
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||'''S'''
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||R
|-
| ||[[Mycoplasm pneumoniae]]||R
|-
| ||[[Rickettsia sp]]||R
|-
| ||[[Mycobacterium avium]]||R
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||R
|-
| ||[[Prevotella melaninogenica]]||I
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||I
|-
| ||[[Fusobacterium necrophorum]]||'''S'''
|-
| ||[[Peptostreptococcus sp.]]||'''S'''
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]

Cefodizime - Revision history