Baclofen withdrawal - Revision history

Elcatracho: /* Evaluation */

2021-01-28T05:36:20Z

Evaluation

← Revisión anterior		Revisión del 05:36 28 ene 2021
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	==Evaluation==		==Evaluation==
	*History ~~and Physical~~ of ~~Baclofen~~ use		*History of baclofen use
			*Physical exam
	*Examination of the pump		*Examination of the pump
	*CPK levels		*CPK levels

Elcatracho: /* Disposition */

2021-01-28T05:35:37Z

Disposition

← Revisión anterior		Revisión del 05:35 28 ene 2021
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	Admit:		Admit:
	*Organ failure		*Organ failure
	*Status epilepticus		*[[Status epilepticus]]
	*Pump malfunction		*Pump malfunction
	*Fever		*Fever

Elcatracho: /* See Also */

2021-01-28T05:34:37Z

Elcatracho: /* Background */

2021-01-28T05:33:50Z

Background

← Revisión anterior		Revisión del 05:33 28 ene 2021
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	==Background==		==Background==
	*[[Baclofen]] (Lioresal) is an anti-spasmodic that works on the as a GABA-b agonist		*[[Baclofen]] (Lioresal) is an anti-spasmodic that works on the as a GABA-B agonist
	*Primarily used in patients with ~~Multiple Sclerosis~~, ~~Cerebral Palsy~~ and ~~Spinal Cord~~ injuries		*Primarily used in patients with [[multiple sclerosis]], [[cerebral palsy]], and spinal cord injuries
	*Often administered intrathecally but does ~~also~~ have an oral formulation		*Often administered intrathecally but does have an oral formulation
	*Withdrawal symptoms thought to be caused by decreased GABA activation		*Withdrawal symptoms thought to be caused by decreased GABA activation

Elcatracho: /* Differential Diagnosis */

2021-01-28T05:32:49Z

Differential Diagnosis

← Revisión anterior		Revisión del 05:32 28 ene 2021
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	*[[Malignant hyperthermia]]		*[[Malignant hyperthermia]]

	{{Template:Sedative/hypnotic withdrawal types ~~(section)~~}}		{{Template:Sedative/hypnotic withdrawal types}}

	==Evaluation==		==Evaluation==

Elcatracho: /* Differential Diagnosis */

2021-01-28T05:32:34Z

Differential Diagnosis

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	*[[Neuroleptic malignant syndrome]]		*[[Neuroleptic malignant syndrome]]
	*[[Malignant hyperthermia]]		*[[Malignant hyperthermia]]

			{{Template:Sedative/hypnotic withdrawal types (section)}}

	==Evaluation==		==Evaluation==

ClaireLewis at 23:49, 14 September 2019

2019-09-14T23:49:17Z

← Revisión anterior		Revisión del 23:49 14 sep 2019
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	==Clinical Features==		==Clinical Features==
	Baclofen withdrawal especially in the case of acute intrathecal pump failure may lead to:		Baclofen withdrawal especially in the case of acute intrathecal pump failure may lead to:
	*High ~~Fevers~~		*High [[fever]]s
	*Confusion		*[[Confusion]], altered mental status
	*Altered mental status
	*Muscle stiffness		*Muscle stiffness
	*Seizures		*[[Seizures]]
	*Rhabdomyolysis		*[[Rhabdomyolysis]]
	*Multiple organ system failure		*Multiple organ system failure
	*Death		*Death

	==Differential Diagnosis==		==Differential Diagnosis==
	*Sepsis		*[[Sepsis]]
	*Meningitis		*[[Meningitis]]
	*Epilepsy		*[[Epilepsy]]
	*Autonomic dysreflexia		*Autonomic dysreflexia
	*Neuroleptic malignant syndrome		*[[Neuroleptic malignant syndrome]]
	*Malignant hyperthermia		*[[Malignant hyperthermia]]

	==Evaluation==		==Evaluation==
	*History and Physical of Baclofen use		*History and Physical of Baclofen use
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	*Electrolytes		*Electrolytes
	*CBC		*CBC
	*LFTs		*[[LFTs]]
	*Coagulation studies		*Coagulation studies

	==Management==		==Management==
	*High doses of benzodiazepines are the mainstay of treatment		*High doses of [[benzodiazepines]] are the mainstay of treatment
	*High dose oral baclofen has been used but has been less effective		*High dose oral baclofen has been used but has been less effective
	*Intrathecal baclofen bolus can be attempted but overdoses are possible with this method		*Intrathecal baclofen bolus can be attempted but overdoses are possible with this method
	*Dantrolene and cyproheptadine can also be considered but their efficacy is still unproven in this situation		*[[Dantrolene]] and [[cyproheptadine]] can also be considered but their efficacy is still unproven in this situation

	==Disposition==		==Disposition==
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	*Pump malfunction		*Pump malfunction
	*Fever		*Fever
	*Loss of ~~Consciousness~~		*Loss of consciousness

	==See Also==		==See Also==
	*[[Cerebral palsy]]		*[[Cerebral palsy]]

ClaireLewis: /* Background */

2016-10-05T05:20:03Z

Background

← Revisión anterior		Revisión del 05:20 5 oct 2016
Línea 1:		Línea 1:
	==Background==		==Background==
	*Baclofen (Lioresal) is an anti-spasmodic that works on the as a GABA-b agonist		*[[Baclofen]] (Lioresal) is an anti-spasmodic that works on the as a GABA-b agonist
	*Primarily used in patients with Multiple Sclerosis, Cerebral Palsy and Spinal Cord injuries		*Primarily used in patients with Multiple Sclerosis, Cerebral Palsy and Spinal Cord injuries
	*Often administered intrathecally but does also have an oral formulation		*Often administered intrathecally but does also have an oral formulation

Neil.m.young: sources should be linked directly as ref in the text

2016-08-01T02:56:31Z

sources should be linked directly as ref in the text

← Revisión anterior		Revisión del 02:56 1 ago 2016
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	==References==		==References==
	<references/>		<references/>
	~~http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514562/~~
	~~https://www.drugs.com/cdi/baclofen.html~~
	~~http://www.ncbi.nlm.nih.gov/pubmed/9711203~~
	~~http://www.clineu-journal.com/article/S0303-8467(02)00009-4/abstract~~
	~~https://www.uptodate.com/contents/baclofen-drug-information?source=search_result&search=baclofen&selectedTitle=1~75~~

	[[Category:Toxicology]]		[[Category:Toxicology]]

Neil.m.young at 02:54, 1 August 2016

2016-08-01T02:54:15Z

← Revisión anterior		Revisión del 02:54 1 ago 2016
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	*High dose oral baclofen has been used but has been less effective		*High dose oral baclofen has been used but has been less effective
	*Intrathecal baclofen bolus can be attempted but overdoses are possible with this method		*Intrathecal baclofen bolus can be attempted but overdoses are possible with this method
	*Dantrolene and cyproheptadine can also be considered but their efficacy is still unproven in this situation.		*Dantrolene and cyproheptadine can also be considered but their efficacy is still unproven in this situation

	==Disposition==		==Disposition==
	Admit:		Admit:

← Revisión anterior		Revisión del 05:34 28 ene 2021
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	*[[Cerebral palsy]]		*[[Cerebral palsy]]
	*[[Baclofen toxicity]]		*[[Baclofen toxicity]]
			*[[Baclofen]]

	==External Links==		==External Links==