Elcatracho: /* See Also */

2021-03-08T16:22:28Z

Humanguy: added dosage forms, dosage strengths, trade name

2017-10-11T20:18:16Z

added dosage forms, dosage strengths, trade name

← Revisión anterior		Revisión del 20:18 11 oct 2017
Línea 1:		Línea 1:
	==Administration==		==Administration==
	*Type: [[Anticoagulant]] (Direct thrombin inhibitor)		*Type: [[Anticoagulant]] (Direct thrombin inhibitor)
	*Dosage Forms:		*Dosage Forms: injectable solution, ready-to-use injectable
			*Dosage Strengths: injectable solution: 100mg/mL; ready-to-use injectable: 50mg/50mL 0.9% NaCl, 125mg/125mL 0.9% NaCl
	*Routes of Administration: IV		*Routes of Administration: IV
	*Common Trade Names:		*Common Trade Names: Acova

	==Adult Dosing==		==Adult Dosing==

ClaireLewis: Created page with "==Administration== Type: Anticoagulant (Direct thrombin inhibitor) Dosage Forms: Routes of Administration: IV Common Trade Names: ==Adult Dosing== *HIT with thro..."

2016-11-12T23:00:14Z

Created page with "==Administration== *Type: Anticoagulant (Direct thrombin inhibitor) *Dosage Forms: *Routes of Administration: IV *Common Trade Names: ==Adult Dosing== *HIT with thro..."

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==Administration==
*Type: [[Anticoagulant]] (Direct thrombin inhibitor)
*Dosage Forms:
*Routes of Administration: IV
*Common Trade Names:

==Adult Dosing==
*[[HIT]] with thrombosis: 2 mcg/kg/min IV infusion, titrate to aPTT 1.5-3x baseline value
*Myocardial infarction: 100 mcg/kg IV bolus + 1-3mcg/kg/min IV infusion x 6-72 hours; goal aPTT 50-85 seconds
*Cerebral thrombosis: 60 mg/day continuous IV infusion x 2 days, then 10mg IV BID x 5 days
*Coronary thrombosis prophylaxis after PCI (in patients at risk for [[HIT]]): 350 mcg/kg IV bolus + 25 mcg/kg/min IV continuous infusion; titrate to maintain activated clotting time 300-450 seconds

==Pediatric Dosing==
''Safety/efficacy not established''
*[[HIT]]: 0.75 mcg/kg/min IV infusion; titrate in increments of 0.1-0.25 mcg/kg/min to goal aPTT 1.5-3x baseline level

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Renal dosing: no adjustment
*Hepatic dosing: more frequent dosage adjustments may be needed. For [[HIT]] treatment in moderate-severe liver disease, initial dose 0.5mcg/kg/min

==Contraindications==
*Allergy to class/drug
*Major bleeding

==Adverse Reactions==
===Serious===
*Major bleeding: GI bleeding, retroperitoneal hemorrhage, intracranial hemorrhage, coronary artery hemorrhage, hematuria
*Angina, coronary artery thrombosis, aortic valve stenosis, MI, cardiac arrest
*Sepsis
*Pulmonary edema
===Common===
*Hypotension
*Chest pain
*Nausea/vomiting, diarrhea
*Headache, backache
*Dyspnea
*Fever

==Pharmacology==
*Half-life: 30-51min, prolonged in hepatic impairment
*Metabolism: Hepatic
*Excretion: Mostly fecal

==Mechanism of Action==
*Binds to and directly inhibits thrombin

==Comments==

==See Also==
*[[Anticoagulant reversal for life-threatening bleeds]]

==References==
<references/>
[[Category:Pharmacology]]

← Revisión anterior		Revisión del 16:22 8 mar 2021
Línea 51:		Línea 51:

	==See Also==		==See Also==
			*[[Coagulopathy (main)]]
	*[[Anticoagulant reversal for life-threatening bleeds]]		*[[Anticoagulant reversal for life-threatening bleeds]]

Argatroban - Revision history

Elcatracho: /* See Also */

Humanguy: added dosage forms, dosage strengths, trade name

ClaireLewis: Created page with "==Administration== *Type: Anticoagulant (Direct thrombin inhibitor) *Dosage Forms: *Routes of Administration: IV *Common Trade Names: ==Adult Dosing== *HIT with thro..."

ClaireLewis: Created page with "==Administration== Type: Anticoagulant (Direct thrombin inhibitor) Dosage Forms: Routes of Administration: IV Common Trade Names: ==Adult Dosing== *HIT with thro..."