Aplastic anemia - Revision history

ClaireLewis at 23:38, 30 September 2019

2019-09-30T23:38:05Z

← Revisión anterior		Revisión del 23:38 30 sep 2019
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	==Background==		==Background==
	*Absence or decreased number of hematopoietic precursor cells → pancytopenia ([[anemia]], [[thrombocytopenia]], neutropenia)		*Absence or decreased number of hematopoietic precursor cells → [[pancytopenia]] ([[anemia]], [[thrombocytopenia]], neutropenia)
	*Causes:		*Causes:
	**Drug-induced ([[chloramphenicol]], [[carbamazepine]], [[valproic acid]], [[phenytoin]])		**Drug-induced ([[chloramphenicol]], [[carbamazepine]], [[valproic acid]], [[phenytoin]])
	**Viral infection ([[parvovirus B19]], [[HIV]], hepatitis), especially in patients with sickle cell disease or immunocompromise		**Viral infection ([[parvovirus B19]], [[HIV]], [[viral hepatitis\|hepatitis]]), especially in patients with [[sickle cell disease]] or immunocompromise
	**Autoimmune		**Autoimmune
	**Congenital (Fanconi anemia)		**Congenital (Fanconi anemia)

	==Clinical Features==		==Clinical Features==
	*Anemia		*[[Anemia]]
	**Weakness, fatigue, dyspnea		**[[Weakness]], [[fatigue]], [[dyspnea]]
	*Thrombocytopenia		*[[Thrombocytopenia]]
	**Mucosal bleeding, petechiae		**Mucosal bleeding, [[petechiae]]
	*Neutropenia		*[[Neutropenia]]
	**Recurrent infections, fever		**Recurrent [[neutropenic fever\|infections]], [[fever]]

	==Differential Diagnosis==		==Differential Diagnosis==
			==Differential Diagnosis==
			===Pancytopenia Causes===
			*[[Acute leukemia]]
			*[[Myelodysplastic syndrome]], [[myelofibrosis]]
			*[[Aplastic anemia]]
			*Infiltrative disease (e.g. [[lymphoma]], [[multiple myeloma]], metastatic carcinoma)
			*[[Paroxysmal nocturnal hemoglobinuria]]
			Drugs/treatments (drugs more commonly associated with pancytopenia)
			*Bone marrow irradiation
			*Chemotherapy(especially anthracyclines, [[methotrexate]])
			*Anti-inflammatories ([[rituximab]], sulfasalazine*, [[colchicine]], [[azathioprine]], [[methotrexate]])
			*Antimicrobials ([[chloramphenicol]], [[ganciclovir]], [[penicillin G]], [[dapsone]]*, [[quinine]]
			*Thiomides ([[propylthiouracil]], [[methimazole]]*, carbimazole)
			*[[Antipsychotics]] ([[clozapine]], [[olanzapine]]
			*[[Procainamide]]
			**[[Cyclophosphamide]]
			**[[Antiepileptics]] ([[phenytoin], [[carbamazepine]], [[phenobarbital]])
			*Infection
			**[[Tuberculosis]]
			**[[AIDS]]
			**[[Leishmaniasis]], [[brucellosis]], [[histoplasmosis]].
			**Viruses causing [[aplastic anemia]] ([[viral hepatitis]], [[Epstein-Barr virus]], [[HIV]], [[parvovirus B19]])
			*[[Systemic lupus erythematosus]]
			*Hypersplenism
			*[[Acute radiation syndrome]]

	==Evaluation==		==Evaluation==
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	==Management==		==Management==
	*Transfuse PRBCs/platelets as needed for severe anemia/thrombocytopenia		*Transfuse [[PRBCs]]/[[platelets]] as needed for severe anemia/thrombocytopenia
	*Antimicrobials if febrile and neutropenic		*[[antibiotics\|Antimicrobials]] if febrile and neutropenic

	==Disposition==		==Disposition==
			*Generally admit

	==See Also==		==See Also==

Mholtz: Text replacement - "-->" to "→"

2017-02-08T17:04:55Z

Text replacement - "-->" to "→"

← Revisión anterior		Revisión del 17:04 8 feb 2017
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	==Background==		==Background==
	*Absence or decreased number of hematopoietic precursor cells ~~-->~~ pancytopenia ([[anemia]], [[thrombocytopenia]], neutropenia)		*Absence or decreased number of hematopoietic precursor cells → pancytopenia ([[anemia]], [[thrombocytopenia]], neutropenia)
	*Causes:		*Causes:
	**Drug-induced ([[chloramphenicol]], [[carbamazepine]], [[valproic acid]], [[phenytoin]])		**Drug-induced ([[chloramphenicol]], [[carbamazepine]], [[valproic acid]], [[phenytoin]])

Neil.m.young: Text replacement - "==Diagnosis==" to "==Evaluation=="

2016-07-24T16:31:11Z

Text replacement - "==Diagnosis==" to "==Evaluation=="

← Revisión anterior		Revisión del 16:31 24 jul 2016
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	==Differential Diagnosis==		==Differential Diagnosis==

	==~~Diagnosis~~==		==Evaluation==
	*CBC: pancytopenia		*CBC: pancytopenia
	*Reticulocyte count: reduced or absent		*Reticulocyte count: reduced or absent

Neil.m.young at 04:01, 13 July 2016

2016-07-13T04:01:10Z

← Revisión anterior		Revisión del 04:01 13 jul 2016
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	==Background==		==Background==
	*~~absence~~ or decreased number of hematopoietic precursor cells --> pancytopenia ([[anemia]], [[thrombocytopenia]], neutropenia)		*Absence or decreased number of hematopoietic precursor cells --> pancytopenia ([[anemia]], [[thrombocytopenia]], neutropenia)
	*Causes:		*Causes:
	**~~drug~~-induced ([[chloramphenicol]], [[carbamazepine]], [[valproic acid]], [[phenytoin]])		**Drug-induced ([[chloramphenicol]], [[carbamazepine]], [[valproic acid]], [[phenytoin]])
	**~~viral~~ infection ([[parvovirus B19]], [[HIV]], hepatitis), especially in patients with sickle cell disease or immunocompromise		**Viral infection ([[parvovirus B19]], [[HIV]], hepatitis), especially in patients with sickle cell disease or immunocompromise
	**~~autoimmune~~		**Autoimmune
	**~~congenital~~ (Fanconi anemia)		**Congenital (Fanconi anemia)

	==Clinical Features==		==Clinical Features==
	*~~anemia~~		*Anemia
	**~~weakness~~, fatigue, dyspnea		**Weakness, fatigue, dyspnea
	*~~thrombocytopenia~~		*Thrombocytopenia
	**~~mucosal~~ bleeding, petechiae		**Mucosal bleeding, petechiae
	*~~neutropenia~~		*Neutropenia
	**~~recurrent~~ infections, fever		**Recurrent infections, fever

	==Differential Diagnosis==		==Differential Diagnosis==
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	==Management==		==Management==
	*~~transfuse~~ PRBCs/platelets as needed for severe anemia/thrombocytopenia		*Transfuse PRBCs/platelets as needed for severe anemia/thrombocytopenia
	*~~antimicrobials~~ if febrile and neutropenic		*Antimicrobials if febrile and neutropenic

	==Disposition==		==Disposition==

Neil.m.young: Text replacement - " w/ " to " with "

2016-07-11T23:04:35Z

Text replacement - " w/ " to " with "

← Revisión anterior		Revisión del 23:04 11 jul 2016
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	*Causes:		*Causes:
	**drug-induced ([[chloramphenicol]], [[carbamazepine]], [[valproic acid]], [[phenytoin]])		**drug-induced ([[chloramphenicol]], [[carbamazepine]], [[valproic acid]], [[phenytoin]])
	**viral infection ([[parvovirus B19]], [[HIV]], hepatitis), especially in patients w/ sickle cell disease or immunocompromise		**viral infection ([[parvovirus B19]], [[HIV]], hepatitis), especially in patients with sickle cell disease or immunocompromise
	**autoimmune		**autoimmune
	**congenital (Fanconi anemia)		**congenital (Fanconi anemia)

ClaireLewis: /* Background */

2016-07-11T00:08:49Z

Background

← Revisión anterior		Revisión del 00:08 11 jul 2016
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	==Background==		==Background==
	*absence or ~~decrease~~ number of hematopoietic precursor cells --> pancytopenia ([[anemia]], [[thrombocytopenia]], neutropenia)		*absence or decreased number of hematopoietic precursor cells --> pancytopenia ([[anemia]], [[thrombocytopenia]], neutropenia)
	*~~causes~~		*Causes:
	**drug-induced ([[chloramphenicol]], [[carbamazepine]], [[valproic acid]], [[phenytoin]])		**drug-induced ([[chloramphenicol]], [[carbamazepine]], [[valproic acid]], [[phenytoin]])
	**viral infection ([[parvovirus B19]], [[HIV]], hepatitis), especially in patients w/ sickle cell disease or immunocompromise		**viral infection ([[parvovirus B19]], [[HIV]], hepatitis), especially in patients w/ sickle cell disease or immunocompromise

ClaireLewis: /* See Also */

2016-07-11T00:06:38Z

ClaireLewis: /* See Also */

2016-07-11T00:06:02Z

ClaireLewis: /* Management */

2016-07-11T00:05:31Z

Management

← Revisión anterior		Revisión del 00:05 11 jul 2016
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	==Management==		==Management==
			*transfuse PRBCs/platelets as needed for severe anemia/thrombocytopenia
			*antimicrobials if febrile and neutropenic

	==Disposition==		==Disposition==

ClaireLewis: /* Diagnosis */

2016-07-11T00:05:17Z

Diagnosis

← Revisión anterior		Revisión del 00:05 11 jul 2016
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	==Diagnosis==		==Diagnosis==
			*CBC: pancytopenia
			*Reticulocyte count: reduced or absent
			*Peripheral smear

	==Management==		==Management==

← Revisión anterior		Revisión del 00:06 11 jul 2016
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	==See Also==		==See Also==
	[[~~aplastic crisis~~]]		*[[Aplastic Crisis]]

	==External Links==		==External Links==

← Revisión anterior		Revisión del 00:06 11 jul 2016
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	==See Also==		==See Also==
			[[aplastic crisis]]

	==External Links==		==External Links==