Angioedema - Revision history

Danbot: Add MedicationDose SMW annotations (7 entries: epinephrine, glucagon, TXA, diphenhydramine, methylprednisolone, icatibant, ecallantide); dosing verified

2026-03-20T16:30:57Z

Add MedicationDose SMW annotations (7 entries: epinephrine, glucagon, TXA, diphenhydramine, methylprednisolone, icatibant, ecallantide); dosing verified

@@ Línea 105: / Línea 105: @@
 |}
 ==See Also==
 *[[Anaphylaxis]]

Spenceemmett: /* Clinical Features */

2022-03-11T21:27:39Z

Clinical Features

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	[[File:Angioedema_post_lisinopril_use_2014-12-08_12-35.jpg\|thumbnail\|Angioedema]]		[[File:Angioedema_post_lisinopril_use_2014-12-08_12-35.jpg\|thumbnail\|Angioedema]]
	[[File:Angioedema2013.jpg\|thumbnail\|Angioedema of tongue]]		[[File:Angioedema2013.jpg\|thumbnail\|Angioedema of tongue]]
	*~~Swelling~~ most often ~~includes~~ face, lips, and/or tongue		*Non-pitting edema that most often affects face, lips, and/or tongue
	*May also involve<ref>https://www.merckmanuals.com/professional/immunology-allergic-disorders/allergic,-autoimmune,-and-other-hypersensitivity-disorders/angioedema?query=angioedema</ref>:		*May also involve<ref>https://www.merckmanuals.com/professional/immunology-allergic-disorders/allergic,-autoimmune,-and-other-hypersensitivity-disorders/angioedema?query=angioedema</ref>:
	**Upper airway--> [[respiratory distress]], [[stridor]]		**Upper airway --> [[respiratory distress]], [[stridor]]
			**Skin --> urticaria suggests histamine-mediated
	**Face, hands, genitals		**Face, hands, genitals
	**Intestines--> [[nausea/vomiting]], [[abdominal pain]], [[diarrhea]], SBO-like presentation		**Intestines --> [[nausea/vomiting]], [[abdominal pain]], [[diarrhea]], SBO-like presentation

	==Differential Diagnosis==		==Differential Diagnosis==

Spenceemmett: /* Clinical Features */

2022-03-11T21:25:22Z

Clinical Features

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	[[File:Angioedema_post_lisinopril_use_2014-12-08_12-35.jpg\|thumbnail\|Angioedema]]		[[File:Angioedema_post_lisinopril_use_2014-12-08_12-35.jpg\|thumbnail\|Angioedema]]
	[[File:Angioedema2013.jpg\|thumbnail\|Angioedema of tongue]]		[[File:Angioedema2013.jpg\|thumbnail\|Angioedema of tongue]]
	*Angioedema
	*Swelling most often includes face, lips, and/or tongue		*Swelling most often includes face, lips, and/or tongue
	*May also involve<ref>https://www.merckmanuals.com/professional/immunology-allergic-disorders/allergic,-autoimmune,-and-other-hypersensitivity-disorders/angioedema?query=angioedema</ref>:		*May also involve<ref>https://www.merckmanuals.com/professional/immunology-allergic-disorders/allergic,-autoimmune,-and-other-hypersensitivity-disorders/angioedema?query=angioedema</ref>:

Spenceemmett: /* Etiologies */

2022-03-11T21:24:52Z

Etiologies

← Revisión anterior		Revisión del 21:24 11 mar 2022
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	===Etiologies===		===Etiologies===
	*'''Allergic angioedema:~~'''~~ [[Allergic reaction\|IgE–mediated type I]] [[Hypersensitivity Reaction\|hypersensitivity reaction]]		*'''Histamine-mediated'''
	*'''Hereditary angioedema:~~'''~~ Congenital or acquired loss of C1 esterase inhibitor		**Allergic angioedema: [[Allergic reaction\|IgE–mediated type I]] [[Hypersensitivity Reaction\|hypersensitivity reaction]]
	**Due to C1 esterase inhibitor deficiency		*'''Bradykinin-mediated'''
	**Leads to unregulated activity of vasoactive mediators (bradykinin) associated with complement pathway		**Hereditary angioedema: Congenital or acquired loss of C1 esterase inhibitor
	**Autosomal dominant		***Due to C1 esterase inhibitor deficiency
	**~~Edema of face, extremities, bowel wall~~		***Leads to unregulated activity of vasoactive mediators (bradykinin) associated with complement pathway
	*'''[[ACE inhibitor\|ACE-I]] induced angioedema:~~''' ACEI~~ adverse reaction from excessive bradykinin		***Autosomal dominant
	*'''Idiopathic ~~angioedema~~'''		**[[ACE inhibitor\|ACE-I]]-induced angioedema: ACE-I adverse reaction from excessive bradykinin
			*'''Idiopathic'''

	==Clinical Features==		==Clinical Features==

Rossdonaldson1: /* Background */

2022-01-06T04:59:50Z

Background

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	==Background==		==Background==
			[[File:Gray1014.png\|thumb\|Anatomy of the posterior pharynx.]]
	*Angioedema is paroxysmal, nondemarcated swelling of dermal or submucosal layers of skin or mucosa		*Angioedema is paroxysmal, nondemarcated swelling of dermal or submucosal layers of skin or mucosa
	**Swelling is asymmetric, nonpitting, and nonpruritic, however can be associated with allergic features depending on cause		**Swelling is asymmetric, nonpitting, and nonpruritic, however can be associated with allergic features depending on cause

Elcatracho: /* ACE-I Induced Angioedema */

2021-05-22T21:50:22Z

ACE-I Induced Angioedema

← Revisión anterior		Revisión del 21:50 22 may 2021
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	===ACE-I Induced Angioedema===		===ACE-I Induced Angioedema===
	*Typical anaphylaxis medications do not ~~effect~~ bradykinin levels<ref>Bas M, Greve J, Stelter K, et al. Therapeutic efficacy of icatibant in angioedema induced by angiotensin-converting enzyme inhibitors: a case series. Ann Emerg Med. 2010; 56(3):278-282.</ref>, but consider:		*Typical anaphylaxis medications do not affect bradykinin levels<ref>Bas M, Greve J, Stelter K, et al. Therapeutic efficacy of icatibant in angioedema induced by angiotensin-converting enzyme inhibitors: a case series. Ann Emerg Med. 2010; 56(3):278-282.</ref>, but consider:
	**[[Epinephrine]] 0.3mg IM		**[[Epinephrine]] 0.3mg IM
	**[[Diphenhydramine]] 50mg IV		**[[Diphenhydramine]] 50mg IV

Elcatracho: /* See Also */

2021-02-18T06:23:51Z

Elcatracho: /* General */

2020-12-10T16:13:00Z

General

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	**2 units		**2 units
	*Consider definitive airway if voice change, hoarseness, stridor, dyspnea		*Consider definitive airway if voice change, hoarseness, stridor, dyspnea
	**Prepare for a [[difficult airway]] which can include need for fiberoptics, ENT/anesthesia assistance, [[surgical airway]], or transfer to the OR		**Prepare for a [[difficult airway]] which can include need for [[Awake intubation\|fiberoptics]], ENT/anesthesia assistance, [[surgical airway]], or transfer to the OR

	===Hereditary Angioedema===		===Hereditary Angioedema===

Ostermayer: /* Ishoo Staging */

2020-10-05T05:27:07Z

Ishoo Staging

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	\| 4\|\|Larynx\|\|0%\|\|0%\|\|100%\|\|24%		\| 4\|\|Larynx\|\|0%\|\|0%\|\|100%\|\|24%
	\|}		\|}
	^

	==See Also==		==See Also==

Ostermayer: /* Ishoo Staging */

2020-10-05T05:26:58Z

Ishoo Staging

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	===Ishoo Staging===		===Ishoo Staging===
	Ishoo Staging may predict severity of disease to help stratify ~~dispostion~~<ref>Ishoo E, et al. Predicting airway risk in angioedema: staging system based on presentation. Otolaryngol Head Neck Surg. 1999; 121(3):263-268.</ref>		Ishoo Staging may predict severity of disease to help stratify disposition. It is based on retrospective study<ref>Ishoo E, et al. Predicting airway risk in angioedema: staging system based on presentation. Otolaryngol Head Neck Surg. 1999; 121(3):263-268.</ref>

	{\| {{table}}		{\| {{table}}
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	\| 4\|\|Larynx\|\|0%\|\|0%\|\|100%\|\|24%		\| 4\|\|Larynx\|\|0%\|\|0%\|\|100%\|\|24%
	\|}		\|}
	^~~Based on retrospective study~~		^

	==See Also==		==See Also==

← Revisión anterior		Revisión del 06:23 18 feb 2021
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	*[[Anaphylaxis]]		*[[Anaphylaxis]]
	*[[Tongue Diagnoses]]		*[[Tongue Diagnoses]]

			{{Related Difficult Airway Pages}}

	==References==		==References==