Amyloidosis - Revision history

Danbot: Add verified PubMed references (PMIDs 31986086)

2026-03-22T10:59:16Z

Add verified PubMed references (PMIDs 31986086)

← Revisión anterior		Revisión del 10:59 22 mar 2026
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	==Background==		==Background==
	*Accumulation of proteins (amyloid fibrils) in tissues		*Accumulation of proteins (amyloid fibrils) in tissues<ref>Rubin J, Maurer MS. Cardiac Amyloidosis: Overlooked, Underappreciated, and Treatable. Annu Rev Med. 2020 Jan 27;71:203-219. PMID 31986086</ref>
	*Heart and kidneys most commonly affected organs		*Heart and kidneys most commonly affected organs
	*Causes:		*Causes:

Rossdonaldson1: /* Clinical Features */

2020-10-24T09:44:56Z

Clinical Features

← Revisión anterior		Revisión del 09:44 24 oct 2020
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	==Clinical Features==		==Clinical Features==
	[[File:PMC3495844 1750-1172-7-54-1.png\|thumb\|]]Systemic light change amyloidosis: A. Macroglossia with lateral scalloping of the tongue. B. Bilateral periorbital purpura. C. Pseudo athletic appearance secondary to diffuse muscular infiltration. D. Voluminous hepatomegaly due to primary hepatic amyloidosis. E. Diffuse bilateral interstitial lung disease. F. Submandibular gland enlargement. G-H. Localized AL amyloidosis. G. Nodular conjunctival amyloidosis. H. Laryngeal supraglottic amyloid lump.]]		[[File:PMC3495844 1750-1172-7-54-1.png\|thumb\|Systemic light change amyloidosis: A. Macroglossia with lateral scalloping of the tongue. B. Bilateral periorbital purpura. C. Pseudo athletic appearance secondary to diffuse muscular infiltration. D. Voluminous hepatomegaly due to primary hepatic amyloidosis. E. Diffuse bilateral interstitial lung disease. F. Submandibular gland enlargement. G-H. Localized AL amyloidosis. G. Nodular conjunctival amyloidosis. H. Laryngeal supraglottic amyloid lump.]]
	*[[Nephrotic syndrome]] with kidney involvement		*[[Nephrotic syndrome]] with kidney involvement
	*Restrictive [[cardiomyopathy]]		*Restrictive [[cardiomyopathy]]

Rossdonaldson1: /* Clinical Features */

2020-10-24T09:44:28Z

Clinical Features

← Revisión anterior		Revisión del 09:44 24 oct 2020
Línea 9:		Línea 9:

	==Clinical Features==		==Clinical Features==
			[[File:PMC3495844 1750-1172-7-54-1.png\|thumb\|]]Systemic light change amyloidosis: A. Macroglossia with lateral scalloping of the tongue. B. Bilateral periorbital purpura. C. Pseudo athletic appearance secondary to diffuse muscular infiltration. D. Voluminous hepatomegaly due to primary hepatic amyloidosis. E. Diffuse bilateral interstitial lung disease. F. Submandibular gland enlargement. G-H. Localized AL amyloidosis. G. Nodular conjunctival amyloidosis. H. Laryngeal supraglottic amyloid lump.]]
	*[[Nephrotic syndrome]] with kidney involvement		*[[Nephrotic syndrome]] with kidney involvement
	*Restrictive [[cardiomyopathy]]		*Restrictive [[cardiomyopathy]]

ClaireLewis at 22:09, 1 October 2019

2019-10-01T22:09:00Z

← Revisión anterior		Revisión del 22:09 1 oct 2019
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	*Restrictive [[cardiomyopathy]]		*Restrictive [[cardiomyopathy]]
	*Sensory and autonomic neuropathies (no CNS involvement)		*Sensory and autonomic neuropathies (no CNS involvement)
	**Sensory neuropathy: symmetrical pattern, progresses distal to proximal		**[[numbness\|Sensory neuropathy]]: symmetrical pattern, progresses distal to proximal
	**Autonomic neuropathy: orthostatic hypotension or nonspecific GI symptoms		**Autonomic neuropathy: orthostatic [[hypotension]] or nonspecific GI symptoms
	*Hepatomegaly, elevated serum AST and AlkPhos		*[[Hepatomegaly]], elevated serum AST and AlkPhos
	*[[Diabetes]] secondary to pancreatic infiltration		*[[Diabetes]] secondary to pancreatic infiltration
	*[[Macroglossia]]		*[[Macroglossia]]
Línea 25:		Línea 25:

	==Management==		==Management==
			*Varies depending on underlying etiology and organ systems involved

	==Disposition==		==Disposition==

Mholtz: Text replacement - "* " to "*"

2017-07-12T21:34:09Z

Text replacement - "* " to "*"

← Revisión anterior		Revisión del 21:34 12 jul 2017
Línea 12:		Línea 12:
	*Restrictive [[cardiomyopathy]]		*Restrictive [[cardiomyopathy]]
	*Sensory and autonomic neuropathies (no CNS involvement)		*Sensory and autonomic neuropathies (no CNS involvement)
	** Sensory neuropathy: symmetrical pattern, progresses distal to proximal		**Sensory neuropathy: symmetrical pattern, progresses distal to proximal
	**Autonomic neuropathy: orthostatic hypotension or nonspecific GI symptoms		**Autonomic neuropathy: orthostatic hypotension or nonspecific GI symptoms
	*Hepatomegaly, elevated serum AST and AlkPhos		*Hepatomegaly, elevated serum AST and AlkPhos

ClaireLewis at 16:16, 3 April 2017

2017-04-03T16:16:20Z

← Revisión anterior		Revisión del 16:16 3 abr 2017
Línea 1:		Línea 1:
	==Background==		==Background==
	*~~accumulation~~ of proteins (amyloid fibrils) in tissues		*Accumulation of proteins (amyloid fibrils) in tissues
	* ~~heart~~ and kidneys most commonly affected organs		*Heart and kidneys most commonly affected organs
			*Causes:
			**Primary amyloidosis, hereditary amyloidosis
			**Secondary (due to systemic inflammatory condition)
			**[[ESRD]]-associated (caused by β2-microglobulin amyloids, not filtered out by dialysis membranes))
			**Senile amyloidosis (causes cardiac amyloid)

	==Clinical Features==		==Clinical Features==
	*[[Nephrotic syndrome]] with kidney involvement		*[[Nephrotic syndrome]] with kidney involvement
Línea 7:		Línea 13:
	*Sensory and autonomic neuropathies (no CNS involvement)		*Sensory and autonomic neuropathies (no CNS involvement)
	** Sensory neuropathy: symmetrical pattern, progresses distal to proximal		** Sensory neuropathy: symmetrical pattern, progresses distal to proximal
	**Autonomic neuropathy: orthostatic hypotension or nonspecific GI sx		**Autonomic neuropathy: orthostatic hypotension or nonspecific GI symptoms
	*Hepatomegaly, elevated serum AST and AlkPhos		*Hepatomegaly, elevated serum AST and AlkPhos
	*[[Diabetes]] secondary to pancreatic infiltration		*[[Diabetes]] secondary to pancreatic infiltration
Línea 15:		Línea 21:

	==Evaluation==		==Evaluation==
	* ~~diagnosis~~ via fat pad biopsy: apple-green birefringence with Congo red stain		*Evaluate for other causes of symptoms
			*Diagnosis via fat pad biopsy: apple-green birefringence with Congo red stain

	==Management==		==Management==

Zipdoc at 06:10, 27 March 2017

2017-03-27T06:10:29Z

← Revisión anterior		Revisión del 06:10 27 mar 2017
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	==References==		==References==
	<references/>		<references/>

			[[Category:Neurology]]
			[[Category:Cardiology]]
			[[Category:Renal]]

Unenthusiastic: Created page with "==Background== accumulation of proteins (amyloid fibrils) in tissues heart and kidneys most commonly affected organs ==Clinical Features== *Nephrotic syndrome with ki..."

2017-03-18T21:24:35Z

Created page with "==Background== *accumulation of proteins (amyloid fibrils) in tissues * heart and kidneys most commonly affected organs ==Clinical Features== *Nephrotic syndrome with ki..."

Página nueva

==Background==
*accumulation of proteins (amyloid fibrils) in tissues
* heart and kidneys most commonly affected organs
==Clinical Features==
*[[Nephrotic syndrome]] with kidney involvement
*Restrictive [[cardiomyopathy]]
*Sensory and autonomic neuropathies (no CNS involvement)
** Sensory neuropathy: symmetrical pattern, progresses distal to proximal
**Autonomic neuropathy: orthostatic hypotension or nonspecific GI sx
*Hepatomegaly, elevated serum AST and AlkPhos
*[[Diabetes]] secondary to pancreatic infiltration
*[[Macroglossia]]

==Differential Diagnosis==

==Evaluation==
* diagnosis via fat pad biopsy: apple-green birefringence with Congo red stain
==Management==

==Disposition==

==See Also==

==External Links==

==References==
<references/>

Amyloidosis - Revision history

Danbot: Add verified PubMed references (PMIDs 31986086)

Rossdonaldson1: /* Clinical Features */

Rossdonaldson1: /* Clinical Features */

ClaireLewis at 22:09, 1 October 2019

Mholtz: Text replacement - "* " to "*"

ClaireLewis at 16:16, 3 April 2017

Zipdoc at 06:10, 27 March 2017

Unenthusiastic: Created page with "==Background== *accumulation of proteins (amyloid fibrils) in tissues * heart and kidneys most commonly affected organs ==Clinical Features== *Nephrotic syndrome with ki..."

Unenthusiastic: Created page with "==Background== accumulation of proteins (amyloid fibrils) in tissues heart and kidneys most commonly affected organs ==Clinical Features== *Nephrotic syndrome with ki..."