Ver el código de «Vitamin K»

''Disambiguation: See [[ketamine]] for street name "vitamin K"''

==General==
*Lasts up to 2 weeks, possibly making anticoagulation post-bleeding risk difficult
*IV form has small risk of anaphylaxis, but risks/benefits must be weighed in serious bleeding
*Type: Vitamin
*Dosage Forms: 100 mcg; 5mg; SC; IM; IV; PO
*Common Trade Names: Generic and Mephyton, K1-1000, Novaplus Vitamin K1

==Adult Dosing==
===[[Vitamin K deficiency]] hypoprothrombinemia===
*2.5-25mg PO QD PRN
*Max: 25mg/dose

===[[Anticoagulant]]-induced hypoprothrombinemia===
*10mg PO x1
*Max: 25mg/dose

===[[Warfarin]] stabilization===
*100 mcg PO QD-bid

==Pediatric Dosing==

===Neonatal deficiency (hemorrhagic disease of the newborn)===
*1mg SC for avoidance of anaphylaxis (IV), hematoma (IM). FFP for serious cases.

===Vitamin K deficiency hypoprothrombinemia===
*2.5-5mg PO QD PRN

===anticoagulant induced hypoprothrombinemia===
*0.5-5mg PO/SC/IM/IV x 1

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Safe
*Renal Dosing
**Adult: not defined
**Pediatric: not defined
*Hepatic Dosing
**Adult: adjust dose amount
**Pediatric: adjust dose amount

==Contraindications==
*Allergy to class/drug
*hereditary hypoprothrombinemia
*overanticoagulation due to heparins
*caution in neonates

==Adverse Reactions==
===Serious===
*anticoagulant resistance
*hypersensitivity reaction, severe or life-threatening (SC, IM, or IV use)
*anaphylaxis (SC, IM, or IV use)
*hyperbilirubinemia (neonates)
*hemolytic anemia (neonates)

===Common===
*taste changes (SC, IM, or IV use)
*flushing (SC, IM, or IV use)
*injection site hematoma
*injection site pain

==Pharmacology==
*Half-life: unknown
*Metabolism: liver, CYP450: unknown
*Excretion: urine, bile
*Mechanism of Action: Used by liver for synthesis of some coagulation factors (II,VII,IX,X,C,S). Timing in the synthesis of these factors impacts reversal of elevated INR (~4 hours: F-VII, ~24 hours: F-II). 

==Comments==

==Indications by Condition==
''The following table is automatically generated from disease/condition pages across WikEM.''

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==See Also==

==References==
<references/>
[[Category:Pharmacology]]
[[Category:FEN]]