Ver el código de «Tinidazole»

==General==
*Type: [[Antiparasitic]]
*Dosage Forms: 250, 500
*Routes of Administration: PO
*Common Trade Names: Tindamax

==Adult Dosing==
*Give with food
===Intestinal Amebiasis===
*2000mg PO daily x 3 days

===Amebic liver abscess===
*2000mg PO daily x 3-5 days

===Giardiasis===
*2000mg PO x 1

===Trichamoniasis===
*2000mg PO x 1
**Treat partner to avoid re-exposure

===Bacterial vaginosis===
*2000mg PO daily x 2 days '''OR''' 1000mg PO daily x 5 days
*Non-pregnant women only

===Urethritis===
*2000mg PO x 1
*Give with azithromycin if not treated with azithromycin previously

===Indications by Disease===
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==Pediatric Dosing==
*Approved for age >3 years
*Give with food
===Indications by Disease===
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===Intestinal Amebiasis===
*50mg/kg PO daily x 3 days
*Max 2000mg/dose

===Amebic liver abscess===
*50mg/kg PO daily x 3-5 days
*Max 2000mg/dose

===Giardiasis===
*50mg/kg PO x 1
*Max 2000mg/dose

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:  C
*[[Lactation risk categories|Lactation risk]]:  Unsafe
*Renal Dosing
**Adult:  Adjust dose amount; 50% usual dose as supplement if on HD
**Pediatric:  Adjust dose amount; 50% usual dose as supplement if on HD
*Hepatic Dosing
**Adult:  No defined dose adjustment but can cause hepatic impairment. Use with caution.
**Pediatric: No defined dose adjustment but can cause hepatic impairment. Use with caution.

==Contraindications==
*Allergy to class/drug
*Pregnancy, 1st trimester
*Breastfeeding up to 72 hours after treatment
*Alcohol use up to 72 hours after treatment
*Hepatic impairment
*Blood dyscrasia
*CNS disorder

==Adverse Reactions==
===Serious===
*Seizure
*Peripheral neuropathy
*Thrombocytopenia
*Hypersensitivity reaction
*Angioedema
*Stevens-Johnson syndrome
*Erythema multiforme
*Bronchospasm

===Common===
*nausea and vomiting
*Anorexia
*Metallic taste
*Fatigue/weakness
*Candidiasis
*Flatulence
*UTI
*Pelvic pain
*Vulvovaginal discomfort
*Vaginal odor
*Menorrhagia
*URI

==Pharmacology==
*Half-life: 12-14 hours
*Metabolism: Liver; CYP450
*Excretion: Urine 20-25%, feces 12%
*Mechanism of Action: Bactericidal; inhibits DNA synthesis

==Comments==
*Black box warning: Carcinogenic risk
==See Also==

==References==
*Epocrates
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[[Category:Pharmacology]]
[[Category:ID]]