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===[[Weakness]]===
*'''Neuromuscular weakness'''
**Upper motor neuron:
*** [[CVA (Main)|CVA]]
*** [[Hemorrhagic stroke]]
*** [[Multiple sclerosis]]
*** [[Amyotrophic Lateral Sclerosis (ALS)]] (upper and lower motor neuron)
**Lower motor neuron:
*** Spinal and bulbar muscular atrophy (Kennedy's syndrome)
**Spinal cord disease:
*** Infection ([[Epidural Abscess (Spinal)|Epidural abscess]]) 
*** Infarction/ischemia
*** Trauma ([[Spinal Cord Syndromes]]) 
*** Inflammation ([[Transverse Myelitis]])
****[[Acute flaccid myelitis]]
*** Degenerative ([[Spinal muscular atrophy]])
*** Tumor
**Peripheral nerve disease:
*** [[Guillain-Barre syndrome]]
*** Toxins ([[Ciguatera]])
*** [[Tick paralysis]]
*** [[Diabetic peripheral neuropathy]]
**Neuromuscular junction disease:
*** [[Myasthenia gravis]] crisis
*** [[Botulism]]
*** [[Organophosphate toxicity]]
*** [[Lambert-Eaton myasthenic syndrome]]
**Muscle disease:
*** [[Rhabdomyolysis]]
*** [[Dermatomyositis]]
*** [[Polymyositis]]
*** Alcoholic myopathy
*'''Non-neuromuscular weakness'''
**Can't miss diagnoses:
*** [[Acute Coronary Syndrome (Main)|ACS]]
*** [[Arrhythmia]]/[[Syncope]]
*** Severe infection/[[Sepsis (Main)|Sepsis]]
*** [[Hypoglycemia]]
*** Periodic paralysis ([[electrolyte disturbance]], K, Mg, Ca)
****[[Hypokalemic periodic paralysis]]
****[[Thyrotoxic periodic paralysis]]
*** [[Respiratory failure]]
**Emergent Diagnoses:
*** Symptomatic [[Anemia]]
*** Severe [[dehydration]]
*** [[Hypothyroidism]]
*** Polypharmacy
*** Malignancy
*** Aortic disease - occlusion, stenosis, dissection
**Other causes of weakness and paralysis
***[[Acute intermittent porphyria]] (ascending weakness)